Indocyanine green fluorescence method for sentinel lymph node biopsy in breast cancer

Lin, Joseph; Lin, Lisheng; Chen, Dar Ren; Lin, Kuo-Juei; Wang, Yufen; Chang, Yu-Jun

doi:10.1016/j.asjsur.2020.02.003

Cited by 35 publications

(22 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Although optical fluorescence imaging is still in its early clinical translational phase, it offers an innovative range of attractive possibilities concerning fluorescence-guided surgery and disease monitoring, for which it may become an important component of the standard care package in the near future. For example, sentinel lymph node biopsy (SLNB) using ICG has already shown to be as accurate as SLNB using a radioactive tracer, demonstrating the clinical potential of fluorescence imaging techniques [121][122][123]. The value of optical fluorescent imaging will be even more evident once it has been complemented and enriched with generally accepted standardization and quantification protocols and ultimately providing benefit for the individual patients based on accurate, reproducible and reliable datasets and execution of standardized imaging protocols and quantification methods for each individual imaging session, similarly as is presently the case for the conventional imaging modalities.…”

Section: Discussionmentioning

confidence: 99%

Targeted optical fluorescence imaging: a meta-narrative review and future perspectives

Schouw

Huisman

Janssen

et al. 2021

Eur J Nucl Med Mol Imaging

View full text Add to dashboard Cite

Purpose The aim of this review is to give an overview of the current status of targeted optical fluorescence imaging in the field of oncology, cardiovascular, infectious and inflammatory diseases to further promote clinical translation. Methods A meta-narrative approach was taken to systematically describe the relevant literature. Consecutively, each field was assigned a developmental stage regarding the clinical implementation of optical fluorescence imaging. Results Optical fluorescence imaging is leaning towards clinical implementation in gastrointestinal and head and neck cancers, closely followed by pulmonary, neuro, breast and gynaecological oncology. In cardiovascular and infectious disease, optical imaging is in a less advanced/proof of concept stage. Conclusion Targeted optical fluorescence imaging is rapidly evolving and expanding into the clinic, especially in the field of oncology. However, the imaging modality still has to overcome some major challenges before it can be part of the standard of care in the clinic, such as the provision of pivotal trial data. Intensive multidisciplinary (pre-)clinical joined forces are essential to overcome the delivery of such compelling phase III registration trial data and subsequent regulatory approval and reimbursement hurdles to advance clinical implementation of targeted optical fluorescence imaging as part of standard practice.

show abstract

Section: Discussionmentioning

confidence: 99%

Targeted optical fluorescence imaging: a meta-narrative review and future perspectives

Schouw

Huisman

Janssen

et al. 2021

Eur J Nucl Med Mol Imaging

View full text Add to dashboard Cite

show abstract

“…This method is based on molecular folerescence by binding ICG to plasma proteins. With this method, while there is a SLN directly in the operating room, adverse side effects and disorders related to lymphatic drainage may cause problems in detecting SLN [13]. Studies have shown that the combined use of preoperative scintigraphic mapping, intraoperative blue dye and gamma probe methods increase the success of SLN detection in breast cancer [14].…”

Section: Discussionmentioning

confidence: 99%

The Effects of Modified Lymphoscintigraphy Techniques on Sentinel Lymph Node Biopsy Success During the COVID-19 Pandemic Period

Yüksel

Çulcu

Doğan

2020

Journal of Investigative Surgery

View full text Add to dashboard Cite

“…Takeuchi és mtsai 6%-os arányban említenek detektált arteria (a.) mammaria interna melletti régióba irányuló nyirokút-elvezetést [15], míg Lin és mtsai ennél is kisebb arányban (1/40) észleltek ilyet [16]. Cong és mtsai munkájában az a. mammaria interna SLN-ek különböző jelölőanyag-beadási technikái mellett magas arányban voltak radioaktívak és fluoreszcens zöldek egyaránt, de felfedezésükben a radioaktivitás segített [17]; ebben a régióban a RI + BD technika esetén is kisebb a BD szerepe [18].…”

Section: Megbeszélésunclassified

Az indociánzöld-fluoreszcencia hasznosítása az emlőrák miatt végzett őrszemnyirokcsomó-biopsziában

Venczel

Maráz

Ambrózay

et al. 2021

View full text Add to dashboard Cite

Összefoglaló. Bevezetés: Napjainkban az őrszemnyirokcsomó felkeresésének legelterjedtebb módszere a radioizotópos és kék festékes kettős jelölés, emellett azonban több más jelölés is alkalmazható. Az indociánzöld-fluoreszcencia ígéretes nyirokút-térképezési módszer, mely a találati arányát tekintve – irodalmi adatok alapján – összevethető a radioizotópos módszerrel. Módszer: Osztályunkon 2020. 03. 31. és 2020. 04. 15. között 10, emlőrák miatt operált betegünknél alkalmaztuk az indociánzöld és a kék festékes kettős jelölés módszerét az őrszemnyirokcsomó felkeresésére. Eredmények: A 10 operált betegünknél összesen 17 őrszemnyirokcsomót azonosítottunk és távolítottunk el. 16 őrszemnyirokcsomó jól festődött indociánzölddel (találati arány: 0,94; 95%-os konfidenciaintervallum [CI ]: 0,73–0,99), míg kék festékkel 9 jelölődött (találati arány: 0,53; 95%-os CI: 0,31–0,74). A szövettani feldolgozás során összesen 2 őrszemnyirokcsomó bizonyult áttétesnek, ezek közül 1 kék és fluoreszcens volt, 1 pedig csak kék festékkel jelölődött. Következtetés: Kezdeti, kis esetszámnál nyert tapasztalataink alapján az indociánzöld jelölés emlőrák során végzett őrszemnyirokcsomó-biopszia esetén jól használható kettős jelölési módszer részeként, kék festékkel kiegészítve. A módszer találati aránya, valamint fals negatív aránya irodalmi adatok alapján nem különbözik szignifikánsan a radioizotópos jelölés módszerétől. Orv Hetil. 2021; 162(8): 293–297. Summary. Introduction: The current practice in sentinel lymph node biopsy for breast cancer is the radioisotope and blue dye dual labelling technique, however, other mapping methods are also available. Indocyanine green fluorescence is one of the best alternatives of the standard technique, with detection rates comparable to those of the radioisotope method. Method: Between 31. 03. 2020 and 15. 04. 2020, a total of 10 sentinel lymph node biopsies for breast cancer were performed using the indocyanine green fluorescence and blue dye dual technique. Results: 17 sentinel lymph nodes were detected and removed in total, from which 16 showed explicit fluorescence activity (detection rate: 0.94; 95% confidence interval [CI]: 0.73–0.99), whilst 9 where blue (detection rate: 0.53; 95% CI: 0.31–0.74). During histopathological examination, 2 sentinel lymph nodes proved to be metastatic, from which 1 was fluorescent and blue, the other was blue only. Conclusion: Regarding our early experience based on a small number of patients, indocyanine green fluorescence, used together with blue dye as part of a dual technique, is a usable method for sentinel lymph node mapping. Based on data from the literature, the detection rate and the false-negative rate of the indocyanine green fluorescence method shows no significant difference from the radioisotope mapping technique. Orv Hetil. 2021; 162(8): 293–297.

show abstract

Indocyanine green fluorescence method for sentinel lymph node biopsy in breast cancer

Cited by 35 publications

References 34 publications

Targeted optical fluorescence imaging: a meta-narrative review and future perspectives

Targeted optical fluorescence imaging: a meta-narrative review and future perspectives

The Effects of Modified Lymphoscintigraphy Techniques on Sentinel Lymph Node Biopsy Success During the COVID-19 Pandemic Period

Az indociánzöld-fluoreszcencia hasznosítása az emlőrák miatt végzett őrszemnyirokcsomó-biopsziában

Contact Info

Product

Resources

About