Indole Alkaloids and Other Constituents from the Plant

Antiplasmodial and GABAA–benzodiazepine receptor binding activities of five plants used in traditional medicine in Mali, West Africa

“…IC 50 (g/ml) b 10 mg/ml 1 mg/ml 0.1 mg/ml collection and the area of collection, and could explain the difference between the two findings. The seasonal variation in chemical composition of root of Securidaca longipedunculata, from West Africa, has been reported before (Wróbel et al, 1996). The difference could also be ascribed to the difference in susceptibility of the parasite between chloroquine and the constituents of extracts.…”

“…Phytochemical investigations have previously been carried out on Securidaca longipedunculata (Delaude, 1971;Nebie et al, 2004). Flavonoids (Ajali and Chukwurah, 2004), alkaloids (Wróbel et al, 1996) and xanthone (Rakuambo et al, 2004) have been isolated from the plant. The presence of these substances could explain the antiplasmodial activity observed in the extract of the plant.…”

Anti-inflammatory activity of extracts of root bark of <i>Securidaca longipedunculata</i> fres (polygalaceae)

“…Phytochemical studies of the root and root bark has led to the isolation of a number of compounds. Some of these include beta-D-(3,4-disinapoyl)fructofuranosyl-alpha-D-(6-sinapoyl)glucopyranoside and beta-D-(3-sinapoyl)fructofuranosyl-alpha-D-(6-sinapoyl)glucopyranoside which are sucrose derivatives (De Tommasi et al, 1993), the alkaloids elymoclavine, and dehydroelymoclavine, an ergoline compound and cinnamonic acid (Wrobel et al, 1996), methyl 2-hydroxybenzoate (methylsalicylate), methyl 2-hydroxy-6-methoxybenzoate esters and its benzyl analogue (Jayasekara et al, 2002), flavonoids (Ajali and Chukwurah, 2004), and the xanthones: 1, 7-Dimethoxy-2-hydroxy-xanthone and 1, 4-dihydroxy-7-methoxy-xanthone (Rakuambo et al, 2004). Also, a number of fatty acids and triglycerols such as coriolic (13-hydroxyoctadeca-cis-9, trans-11-dienoic) acid, 11-hydroxyhexadeca-cis-7, trans-9-dienoic acid and 9-hydroxytetradecacis-5, trans-7-dienoic acid have been isolated from the seed oil of S. longipedunculata (Smith et al, 1979).…”

Acute and Sub-Acute Oral Toxicity Studies of Aqueous Extract of Securidaca Longepedunculata Fresen (Polygalaceae) Root Barks in Rodents.

“…Indeed, pharmacological studies on S longepedunculata showed some anti-inflammatory, antiulcer, antianemia and antiplasmodial properties of this species extracts (Ojewole et al, 2008). Furthermore, phytochemical investigations of several parts of the plant revealed presence of saponins (Ndamitso et al, 2013;Stevenson et al, 2009), flavonoids (Auwal et al, 2012;Muanda et al, 2010), alkaloids (Wrobel et al, 1996), steroids (Meli et al, 2007), sucrose derivatives (De Tommasi et al, 1993), phenolic acids (Muanda et al, 2010) and volatile oils (Nebié et al, 2004;Jayasekara et al, 2005). Although a lot of medicinal plants are widely used and assumed to be safe, they could potentially be toxic (Nasri and Shirzad, 2013).…”