Indolizine: A Promising Framework for Developing a Diverse Array of C−H Functionalized Hybrids

Abstract

C−H functionalized indolizines have emerged as a modern sustainable protocol, as it offers robust applications in the field of agriculture, medicine and pharmaceutical sciences. In recent times, a number of effective methods for the C−C, C−P and C−S bond formation via C−H functionalization of indolizines have been established. The present review article provides a thorough assessment of recent developments in the C−H functionalization of indolizines. The review has been categorized based on C−C, C−P and C−S bond formation using conventional as well as non‐conventional methodologies. Moreover, the reaction mechanism has been discussed in elaborated form.

Synthesis and Photochemical Characterization of Indolizine Fluorophores Obtained by a Multicomponent Palladium Iodide−Catalyzed Oxidative Aminocarbonylation Approach

“…[1] Moreover, some interesting organic fluorophores possess the indolizine core as the key structural unit, [2] and indolizine derivatives are useful substrates for the preparation of more complex molecular architectures. [3] Accordingly, several synthetic efforts have been devoted to the synthesis of indolizines, [4] and the development of new efficient synthetic approaches for their production is still of considerable interest in current research. Among functionalized indolizines, 2-(indolizin-3yl)acetamides are of particular interest, as they are known to act as orexin receptor antagonists, and are therefore useful for the treatment of several diseases and disorders, such as eating disorders, sleep disorders, cognitive dysfunctions in psychiatric and neurological disorders, drug dependence, obesity, and type II diabetes.…”

“…[1] Moreover, some interesting organic fluorophores possess the indolizine core as the key structural unit, [2] and indolizine derivatives are useful substrates for the preparation of more complex molecular architectures. [3] Accordingly, several synthetic efforts have been devoted to the synthesis of indolizines, [4] and the development of new efficient synthetic approaches for their production is still of considerable interest in current research.…”