Indomethacin Arthropathy of Hips

Vital Microscopy of Bone Remodelling in Rabbit Ear Chambers

“…Idiopathic, aseptic, ischaemic necrosis of the femoral head in adults is a well-known disabling hip disease (Zinn 1971). As reported by Arora (1968), Desproges-Gotteron et al (1971) and Solomon (1973), secondary aseptic necrosis in the femoral head may be ascribed to indomethacin medication. As outlined by Solomon (1973), the pathogenesis III of drug-induced arthropathy is still a matter of considerable controversy.…”

“…Indomethacin medication is widely used in the treatment of musculoskeletal disorders, including degenerative joint disease (osteoarthritis). However, according to Arora (1968), Desproges-Gotteron et at (1971) and Solomon (1973), the drug may induce a disabling arthropathy, especially in weight-bearing joints. If this is so the indications for using this potent anti-inflammatory drug may have to be reassessed.…”

Indomethacin induced avascular necrosis of head of femur

“…Chemically induced avascular necrosis of bone is well documented and indomethacin is one of the analgesic anti-inflammatory agents implicated (box 1). The occurrence was first documented in 1968 1. The rate of articular destruction in indomethacin induced arthropathy is slower than that in steroid induced arthropathy 2.…”

Stenting complex aortic arch obstructions

“…However, these agents are associated with major and minor side effects, particularly in the elderly population (1). It was initially suggested that NSAIDs (especially indomethacin) might cause specific arthropathy (referred to as an indomethacin, or analgetic, hip), which is characterized by extensive cartilage and bone attrition and apparent retention of joint space (4–7).…”