Indoor bacterial microbiota and development of asthma by 10.5 years of age

Karvonen, Anne M.; Kirjavainen, Pirkka V.; Täubel, Martin; Jayaprakash, Balamuralikrishna; Adams, Rachel; Sordillo, Joanne E.; Gold, Diane R.; Hyvärinen, Anne; Remes, Sami; Mutius, Erika von; Pekkanen, Juha

doi:10.1016/j.jaci.2019.07.035

Cited by 59 publications

(58 citation statements)

References 37 publications

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“…In mice, the LM clusters highly by cage, shipment and vendor suggesting a clear impact of the living conditions [7]. The living conditions could then represent an important source of variations of the LM and might also be among the factors able to predispose to lung diseases in dogs as it has been shown for asthma in human medicine for example [8][9][10].…”

Section: Introductionmentioning

confidence: 93%

Assessment of the lung microbiota in dogs: influence of the type of breed, living conditions and canine idiopathic pulmonary fibrosis

et al. 2020

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Background: Literature about the lung microbiota (LM) in dogs is sparse. Influence of breed and living conditions on the LM in healthy dogs is currently unknown, as well as the influence of chronic respiratory diseases such as canine idiopathic pulmonary fibrosis (CIPF) in West highland white terriers (WHWTs). Aims of this study were (1) to assess the characteristics of the healthy LM according to breed and living conditions, and (2) to study LM changes associated with CIPF in WHWTs. Forty-five healthy dogs divided into 5 groups: domestic terriers (n = 10), domestic shepherds (n = 11), domestic brachycephalic dogs (n = 9), domestic WHWTs (n = 6) (H-WHWTs) and experimental beagles (n = 9) and 11 diseased WHWTs affected with CIPF (D-WHWTs) were included in the study to achieve those objectives.Results: In healthy domestic dogs, except in H-WHWTs, the presence of few discriminant genera in each type of breed was the only LM modification. LM of experimental dogs displayed a change in b-diversity and an increased richness compared with domestic dogs. Moreover, Prevotella_7 and Dubosiella genera were more abundant and 19 genera were discriminant in experimental dogs. LM of both H-WHWTs and D-WHWTs revealed increased abundance of 6 genera (Brochothrix, Curvibacter, Pseudarcicella, Flavobacteriaceae genus, Rhodoluna and Limnohabitans) compared with other healthy domestic dogs. Brochothrix and Pseudarcicella were also discriminant in D-WHWTs compared with H-WHWTs and other healthy domestic dogs.Conclusions: In domestic conditions, except for H-WHWT, the breed appears to have minor influence on the LM. LM modifications were found in experimental compared with domestic living conditions. LM modifications in H-WHWTs and D-WHWTs compared with other healthy domestic dogs were similar and seemed to be linked to the breed. Whether this breed difference might be related with the high susceptibility of WHWTs for CIPF requires further studies.

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Section: Introductionmentioning

confidence: 93%

Assessment of the lung microbiota in dogs: influence of the type of breed, living conditions and canine idiopathic pulmonary fibrosis

et al. 2020

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“…A recent indoor microbiome study reported that the sum relative abundance of intercorrelated genera showed much stronger association to asthma than any single genus [38]. Thus, the protective effect can be more accurately assessed by microbial clusters.…”

Section: Resultsmentioning

confidence: 99%

“…The theory has gained supports from human gut [1], but heterogeneous results were produced for indoor microbiome studies. A cross-sectional study reported that children lived in farm environment were exposed to greater variety of environmental microorganisms, providing protective effects for asthma and atopy [7], and a few subsequent cohort studies also supported the claim [38, 41]. However, there were several studies failed to identify the pattern [9-11, 42].…”

Section: Discussionmentioning

confidence: 99%

“…Alphaproteobacteria is an extraordinarily diverse and ancient group of bacteria, and its members are widely distributed in various ecological niches, such as soil, water, air and even low-nutrient environments as deep oceanic sediments and glacial ice [43, 44]. Two birth cohort studies showed that Alphaproteobacteria was present in higher abundance in farm homes compared to urban homes, providing protective effect for asthma development [9, 38]. Similarly, Actinobacteria is also a diverse class of bacteria that is widely distributed in terrestrial and aquatic ecosystems [45, 46].…”

Section: Discussionmentioning

confidence: 99%

“…Similarly, Actinobacteria is also a diverse class of bacteria that is widely distributed in terrestrial and aquatic ecosystems [45, 46]. The protective association between Actinobacteria and asthma has been reported in one indoor study [38], and also in a sputum study of nonasthmatic subjects compared with asthmatic subjects [47].…”

Section: Discussionmentioning

confidence: 99%

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Derived ecological niches of indoor microbes are crucial for asthma symptoms in university dormitories

Meng

et al. 2020

Preprint

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Increasing evidences from home environment indicate that microbiome community is associated with asthma. However, indoor microbiome composition can be highly diverse and dynamic, and thus current studies fail to produce consistent association. Chinese university dormitories are special high-density dwellings with a standard built environment and personal characteristics for occupants, which can be used to disentangle the complex interactions between microbes, environmental characteristics and asthma.Settled air dust and floor dust was collected from 87 dormitory rooms in Shanxi University. Bacterial community was characterized by 16S rRNA amplicon sequencing. Students (n = 357) were surveyed for asthma symptoms.Asthma symptoms were not associated with the overall bacterial richness, but associated with different phylogenetic classes. Taxa richness and abundance in Clostridia and Bacteroidia were positively associated with asthma (p < 0.05), and these taxa were mainly derived from human gut. Taxa richness (p < 0.1) and abundance (p < 0.05) in Alphaproteobacteria and Actinobacteria were protectively associated with asthma, and these taxa were mainly derived from outdoor environment. Building age, floor and curtain cleaning frequency shaped the overall bacterial community of air dust (p < 0.05). Frequent curtain cleaning increased the relative abundance of 10 protective genera (p < 0.05), and old buildings had mix effects to protective genera (p < 0.05).Our data shows that taxa from different phylogenetic classes and ecological niches have different health effects, indicating the importance of incorporating evolutionary and ecological concepts in revealing general patterns in the microbiome asthma association analysis.

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Salivary microbiome and asthma risk in children with orofacial defects

Chen

Huang

et al. 2023

Pediatric Pulmonology

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BackgroundPatients with congenital orofacial defects, cleft lip (CL), cleft palate (CP), and cleft lip and palate (CLP) have continuous exposure of the respiratory system to the microbiome from the oral environment, offering opportunities to develop mucosal immunity in the airway. This two‐part study aims to analyze data on asthma occurrence in CL, CP, and CLP infants and the composition of the salivary microbiome, and to evaluate the oral microbiota and its association with the risk of developing childhood asthma.MethodsPatient data from the research database of Chang Gung Memorial Hospital from 2004 to 2015 were retrospectively analyzed by multivariable regression. Diseases diagnoses were defined by ICD codes. Asthma must also meet the criteria for receiving selective β2 agonistic or/and inhaled corticosteroid treatments twice within 1 year. Analysis of the saliva microbiome was performed prospectively from 2016 to 2020 in 10 healthy term infants and 10 CLP infants on postnatal 7th day, 1 month, and 6 months by next‐generation sequencing.ResultsAsthma and nonasthma groups included 988 and 3952 patients, respectively. The incidence of asthma development was higher in patients with CP than in CL and CLP groups (aOR: 5.644, CI: 1.423–22.376). The species composition of the microbiome at 1 and 6 months was significantly different between infants with CLP and healthy infants.ConclusionChildren with orofacial defects have a higher risk of developing asthma with a possible contribution from oral microbiota in the early months of life.

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Indoor bacterial microbiota and development of asthma by 10.5 years of age

Cited by 59 publications

References 37 publications

Assessment of the lung microbiota in dogs: influence of the type of breed, living conditions and canine idiopathic pulmonary fibrosis

Assessment of the lung microbiota in dogs: influence of the type of breed, living conditions and canine idiopathic pulmonary fibrosis

Derived ecological niches of indoor microbes are crucial for asthma symptoms in university dormitories

Salivary microbiome and asthma risk in children with orofacial defects

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