Indoor Environmental Exposures and Exacerbation of Asthma: An Update to the 2000 Review by the Institute of Medicine

Kanchongkittiphon, Watcharoot; Mendell, Mark J.; Gaffin, Jonathan M.; Wang, Grace; Phipatanakul, Wanda

doi:10.1289/ehp.1307922

Cited by 353 publications

(293 citation statements)

References 112 publications

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“…Relatedly, indoor endotoxin exposure is also a strong risk factor for asthma exacerbation (35). Although the TREM1 gene itself was not differentially expressed in our data, the body of transcriptomic evidence presented here implicates increased TREM-1 signaling as a potential early molecular indicator of worsening asthma control.…”

Section: Discussionmentioning

confidence: 49%

Gene Expression Profiling in Blood Provides Reproducible Molecular Insights into Asthma Control

Croteau‐Chonka¹,

Qiu²,

Martínez

et al. 2017

Am J Respir Crit Care Med

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Rationale: Maintaining optimal symptom control remains the primary objective of asthma treatment. Better understanding of the biologic underpinnings of asthma control may lead to the development of improved clinical and pharmaceutical approaches.Objectives: To identify molecular pathways and interrelated genes whose differential expression was associated with asthma control.Methods: We performed gene set enrichment analyses of asthma control in 1,170 adults with asthma, each with gene expression data derived from either whole blood (WB) or unstimulated CD4 1 T lymphocytes (CD4), and a self-reported asthma control score representing either the preceding 6 months (chronic) or 7 days (acute). Our study comprised a discovery WB cohort (n = 245, chronic) and three independent, nonoverlapping replication cohorts: a second WB set (n = 448, acute) and two CD4 sets (n = 300, chronic; n = 77, acute). Measurements and Main Results:In the WB discovery cohort, we found significant overrepresentation of genes associated with asthma control in 1,106 gene sets from the Molecular Signatures Database (false discovery rate, ,5%). Of these, 583 (53%) replicated in at least one replication cohort (false discovery rate, ,25%). Suboptimal control was associated with signatures of eosinophilic and granulocytic inflammatory signals, whereas optimal control signatures were enriched for immature lymphocytic patterns. These signatures included two related biologic processes related to activation by TREM-1 (triggering receptor expressed on myeloid cells 1) and lipopolysaccharide. Conclusions:Together, these results demonstrate the existence of specific, reproducible transcriptomic components in blood that vary with degree of asthma control and implicate a novel biologic target (TREM-1).

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Section: Discussionmentioning

confidence: 49%

Gene Expression Profiling in Blood Provides Reproducible Molecular Insights into Asthma Control

Croteau‐Chonka¹,

Qiu²,

Martínez

et al. 2017

Am J Respir Crit Care Med

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“…Se ha demostrado que la exposición persistente a alérgenos a los cuales el paciente está sensibilizado, tales como ácaros del polvo, caspa de gato, caspa de perro y cucaracha, aumentan los sínto-mas y las exacerbaciones de asma 37 . lo anterior es especialmente relevante cuando además se asocia una infección viral 38 .…”

Section: Alérgenosunclassified

“…Se ha demostrado que la exposición crónica al humo del cigarrillo se asocia a un aumento de las exacerbaciones de asma y por otro lado la exposición pasiva o activa al humo de cigarrillo en pacientes con asma puede causar resistencia al tratamiento con corticoides inhalados 37 . De esta manera la exposición a este contaminante es un factor muy importante a evaluar en pacientes con asma severo problemático 38 .…”

Section: Humo De Cigarrillounclassified

“…En el proceso de combustión se produce monóxido de carbono (CO), dióxido de azufre (SO 2 ), dióxi-do de nitrógeno (NO 2 ), material particulado con diámetro aerodinámico menor a 10 μm (PM 10 ) y material particulado con diámetro aerodinámico menor a 2,5 μm (PM 2,5 ) 39 . de todos los mencionados el más importante es el no 2 , demostrándose asociación entre la exposición a este contaminante y exacerbaciones de asma 37 . de los sistemas de calefacción por combustión el más contaminante es la estufa a leña, seguido por parafina, siendo el menos contaminante el gas licuado 40 .…”

Section: Contaminantesunclassified

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Consenso chileno SER-SOCHINEP para el manejo del asma severo en el niño

et al. 2016

Rev. chil. enferm. respir.

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“…[3][4][5][6][7] Until now, the causal agents and the mechanisms behind the association between moisture damage and the adverse health effects are not well known. It has been suggested that microbial components such as cell fragments or spores shed during fungal growth in moisture-damaged buildings may induce inflammatory responses.…”

Section: Introductionmentioning

confidence: 99%

Early age exposure to moisture damage and systemic inflammation at the age of 6 years

et al. 2018

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Cross‐sectional studies have shown that exposure to indoor moisture damage and mold may be associated with subclinical inflammation. Our aim was to determine whether early age exposure to moisture damage or mold is prospectively associated with subclinical systemic inflammation or with immune responsiveness in later childhood. Home inspections were performed in children's homes in the first year of life. At age 6 years, subclinical systemic inflammation was measured by serum C‐reactive protein (CRP) and blood leukocytes and immune responsiveness by ex vivo production of interleukin 1‐beta (IL‐1β), IL‐6, and tumor necrosis factor alpha (TNF‐α) in whole blood cultures without stimulation or after 24 hours stimulation with phorbol 12‐myristate 13‐acetate and ionomycin (PI), lipopolysaccharide (LPS), or peptidoglycan (PPG) in 251‐270 children. Moisture damage in child's main living areas in infancy was not significantly associated with elevated levels of CRP or leukocytes at 6 years. In contrast, there was some suggestion for an effect on immune responsiveness, as moisture damage with visible mold was positively associated with LPS‐stimulated production of TNF‐α and minor moisture damage was inversely associated with PI‐stimulated IL‐1β. While early life exposure to mold damage may have some influence on later immune responsiveness, it does not seem to increase subclinical systemic inflammation in later life.

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Indoor Environmental Exposures and Exacerbation of Asthma: An Update to the 2000 Review by the Institute of Medicine

Cited by 353 publications

References 112 publications

Gene Expression Profiling in Blood Provides Reproducible Molecular Insights into Asthma Control

Gene Expression Profiling in Blood Provides Reproducible Molecular Insights into Asthma Control

Consenso chileno SER-SOCHINEP para el manejo del asma severo en el niño

Early age exposure to moisture damage and systemic inflammation at the age of 6 years

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