Induced Hypothermia Preserves the Functional Enterocyte Mass in A Porcine Multiple Trauma Model

Despite resuscitation, gut dysfunction promotes distant organ injury. In addition, postresuscitation nosocomial and iatrogenic 'hits' exaggerate the immune response, contributing to MODS. This was a provocative concept, suggesting infectious and noninfectious causes of inflammation may trigger, heighten, and perpetuate an inflammatory response culminating in MODS and death. Emerging evidence suggests posttraumatic injury mechanisms, such as intestinal mucosal disruption and shifting of the gut microbiome to a pathobiome. In addition, traumatic brain injury activates the gut-brain axis and increases intestinal permeability.

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The gut in trauma

Patel

Rosenthal

Miller

et al. 2016

Current Opinion in Critical Care

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Induced Hypothermia Preserves the Functional Enterocyte Mass in A Porcine Multiple Trauma Model

Abstract: Ð 250 wordsIntroduction: Multiple organ dysfunction syndrome (MODS) and the resulting multiple organ

Cited by 1 publication

References 30 publications

The gut in trauma

The gut in trauma

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