2017
DOI: 10.3389/fcell.2016.00152
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Induced Pluripotent Stem Cells for Traumatic Spinal Cord Injury

Abstract: Spinal cord injury (SCI) is a common cause of mortality and neurological morbidity. Although progress had been made in the last decades in medical, surgical, and rehabilitation treatments for SCI, the outcomes of these approaches are not yet ideal. The use of cell transplantation as a therapeutic strategy for the treatment of SCI is very promising. Cell therapies for the treatment of SCI are limited by several translational road blocks, including ethical concerns in relation to cell sources. The use of iPSCs i… Show more

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Cited by 58 publications
(54 citation statements)
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“…The various cell types that have been assessed in preclinical studies include neural stem or precursor cells, oligodendrocyte precursor cells, olfactory ensheathing cells, Schwann cells, umbilical cord mesenchymal stem cells, amongst others 176,193 . Cell transplantation into the transected cord has been shown to promote the recovery of motor function, including coordinated walking 194 , paw use and climbing 195 , in addition to improved bladder function 196 and phrenic nerve activity 197 in animal models.…”
Section: [H2] Current Clinical Studiesmentioning
confidence: 99%
“…The various cell types that have been assessed in preclinical studies include neural stem or precursor cells, oligodendrocyte precursor cells, olfactory ensheathing cells, Schwann cells, umbilical cord mesenchymal stem cells, amongst others 176,193 . Cell transplantation into the transected cord has been shown to promote the recovery of motor function, including coordinated walking 194 , paw use and climbing 195 , in addition to improved bladder function 196 and phrenic nerve activity 197 in animal models.…”
Section: [H2] Current Clinical Studiesmentioning
confidence: 99%
“…However, using hiPSCs avoids the controversial ethical issues associated with human embryo derived hESCs. Furthermore, hiPSCs can be more readily used for clinical treatment, as patient‐derived hiPSCs reduce the risk of immune rejection when transplanted back into the original patient …”
Section: Introductionmentioning
confidence: 99%
“…ncRNAs can reduce the amount of reprogramming factors as they specifically target multiple pathways. Traditionally, lentivirus has been the reprogramming vector of choice; other viral vectors such as Sendai and adenovirus to lower transformation risks have been used with lower efficacy [122][123][124]. Excellent reviews describing more details for reprogramming protocol improvements are available [125][126][127].…”
Section: Induced Pluripotent Stem Cells (Ipscs)mentioning
confidence: 99%