Inducible Nitric Oxide Expression Correlates with the Level of Inflammation in Periapical Cysts

Abstract

Objectives In an attempt to elucidate if inducible nitric oxide expression (iNOS) is correlated with the level of inflammation in periapical cysts with accuracy, the goal of this study was to evaluate the expression of iNOS in these ones. Methods 30 cases were included in this study being iNOS evaluated by means of immunohistochemistry. Statistical analysis was performed by Kruskal-Wallis non-parametric test followed by the post-hoc Dunn’s test. Results iNOS stain was detected throughout the epithelium, subepithelial fibroblasts and macrophages in all cases, indistinctly. Nevertheless, iNOS immunostaining in periapical cysts was different according to the levels of inflammation, being the strongest effect associated with intense inflammatory infiltrate. Conclusions Taken together, our results indicate that immunoreactivity of iNOS was expressed in several cellular types present in periapical cyst, being positively correlated with the level of inflammation. Therefore, iNOS expression plays an important role in the pathogenesis of periapical cysts.

Possible recurrence of keratocyst in nevoid basal cell carcinoma syndrome: A review of literature

“…[ 20 ] Keratocyst is different from other odontogenic cyst. Matsumoto and Ribeiro[ 62 ] indicated that immunoreactivity of inducible nitric oxide expression was expressed in several cellular types present in periapical cyst, being positively correlated with the level of inflammation. Therefore, inducible nitric oxide expression plays an important role in the pathogenesis of periapical cysts.…”

“…Matsumoto and Ribeiro[ 62 ] reported that the value of fine-needle aspiration biopsy in cystic lesions of the maxillofacial region is found as successful as in the solid lesions.…”