“…[35] Besides TfR targeting, which promotes the increase of nanoparticle crossing through the BBB by transcellular pathway, other approaches have been proposed to transiently and safely increase the BBB permeability and the consequent paracellular transport of nanoparticles/compounds to the brain. The most relevant examples include the injection of recombinant human vascular endothelial growth factor, [36] the use of focused ultrasound, [37] and the magnetothermal stimulation. [38] In this context, AbLMNV represents a multifunctional nanoplatform, that can be locally accumulated with a static magnetic field, it is able to promote dual targeting towards both the endothelial cells of the BBB and the GBM cells, and, finally, it induces significant temperature increment when exposed to an AMF; in principle, the nanoparticle heating could be exploited, transiently, for promoting the BBB crossing, and, chronically, for GBM treatment.…”