Inducing occlusion effect in Y-shaped vessels using high-intensity focused ultrasound: finite element analysis and phantom validation

Percutaneous thermal ablation has proved to be an effective modality for treating both benign and malignant tumors in various tissues. Among these modalities, radiofrequency ablation (RFA) is the most promising and widely adopted approach that has been extensively studied in the past decades. Microwave ablation (MWA) is a newly emerging modality that is gaining rapid momentum due to its capability of inducing rapid heating and attaining larger ablation volumes, and its lesser susceptibility to the heat sink effects as compared to RFA. Although the goal of both these therapies is to attain cell death in the target tissue by virtue of heating above 50 o C, their underlying mechanism of action and principles greatly differs. Computational modelling is a powerful tool for studying the effect of electromagnetic interactions within the biological tissues and predicting the treatment outcomes during thermal ablative therapies. Such a priori estimation can assist the clinical practitioners during treatment planning with the goal of attaining successful tumor destruction and preservation of the surrounding healthy tissue and critical structures. This review provides current state-ofthe-art developments and associated challenges in the computational modelling of thermal ablative techniques, viz., RFA and MWA, as well as touch upon several promising avenues in the modelling of laser ablation, nanoparticles assisted magnetic hyperthermia and noninvasive RFA. The application of RFA in pain relief has been extensively reviewed from modelling point of view. Additionally, future directions have also been provided to improve these models for their successful translation and integration into the hospital work flow.

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“…Acoustic heat deposition with an interstitial ultrasound transducer is mostly modelled as (Jiang et al, 2012, Scott et al, 2014:…”

Section: Modelling Of Heat Source For Ultrasound Ablationmentioning

confidence: 99%

Thermal ablation of biological tissues in disease treatment: A review of computational models and future directions

Singh

Melnik

2020

Electromagnetic Biology and Medicine

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“…83 Due to their suitable mechanical properties, PAA-based gels also allow the construction of heat-sensitive vasculature-mimicking phantoms. 84 In these phantoms, a thin-wall vessel compartment is produced using a thermal-sensitive powder and silicon-based gel. Due to the optical transparency of the surrounding PAA gel, the temperature changes of the vessel-mimicking component could be visually observed during HIFU sonication.…”

Section: Acrylamide Phantomsmentioning

confidence: 99%

Tissue-Mimicking Gel Phantoms for Thermal Therapy Studies

et al. 2014

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Tissue-mimicking phantoms that are currently available for routine biomedical applications may not be suitable for high-temperature experiments or calibration of thermal modalities. Therefore, design and fabrication of customized thermal phantoms with tailored properties are necessary for thermal therapy studies. A multitude of thermal phantoms have been developed in liquid, solid, and gel forms to simulate biological tissues in thermal therapy experiments. This article is an attempt to outline the various materials and techniques used to prepare thermal phantoms in the gel state. The relevant thermal, electrical, acoustic, and optical properties of these phantoms are presented in detail and the benefits and shortcomings of each type are discussed. This review could assist the researchers in the selection of appropriate phantom recipes for their in vitro study of thermal modalities and highlight the limitations of current phantom recipes that remain to be addressed in further studies.

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“…The long term effects of most Focused Ultrasound and HIFU treatments are still unknown and knowledge about complications of its use is scarce. The ultrasound technology has been proved to perform thermal ablation on veins 8 and recently the technique is being performed to obtain thermal ablation of the saphenous and varicose veins. The focus of the ultrasound beam is pivotal to obtain the expected results without complications.…”

Section: Introductionmentioning

confidence: 99%

Occlusion of the popliteal artery after focused ultrasound treatment - a case report

Faccini¹,

Souza²,

Arendt³

2018

JTAVR

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The use of focused ultrasound and highintensity focused ultrasound (HIFU) is common in physical therapy and medical procedures. The ultrasound produces heat and can be used to treat several diseases. We report a case of a 49-year-old male that had a knee injury after mild trauma. The patient started physical therapy sessions to treat the injury. Ipsilateral calf claudication started a few hours after the focused ultrasound was used to heat the popliteal area progressing to symptoms of acute arterial occlusion in two weeks. We started anticoagulation and confirmed popliteal thrombosis with duplex scan and computed tomography. The 5 years follow up showed good clinical recovery and recanalization of the artery. This case reminds us that the focused ultrasound should not be considered harmless and life-threatening complications may occur. The inadvertent heating of neighboring structures and recanalization of the heated vessel may happen.

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Inducing occlusion effect in Y-shaped vessels using high-intensity focused ultrasound: finite element analysis and phantom validation

Cited by 4 publications

References 20 publications

Thermal ablation of biological tissues in disease treatment: A review of computational models and future directions

Thermal ablation of biological tissues in disease treatment: A review of computational models and future directions

Tissue-Mimicking Gel Phantoms for Thermal Therapy Studies

Occlusion of the popliteal artery after focused ultrasound treatment - a case report

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