Induction of a chemoattractive proinflammatory cytokine response after stimulation of keratinocytes with Propionibacterium acnes and coproporphyrin III

Schaller, Martin; Loewenstein, Matthew S.; Borelli, Claudia; Jacob, K.; Vogeser, Michael; Burgdorf, Walter H. C.; Plewig, Gerd

doi:10.1111/j.1365-2133.2005.06530.x

Cited by 100 publications

(78 citation statements)

References 19 publications

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“…Furthermore the recovery time of 3 h was not sufficient to track a complete restoration to baseline values. The effect of skin pH on the growth of Proprionibacterium acnes [25, 26], the induction of an inflammatory process [27] and the negative impact of oleic acid in the pilosebaceus glands on the growth of P. acnes [28] are known. Regular sauna seems to decrease one of the basic requirements for the development and aggravation of acne [29].…”

Section: Discussionmentioning

confidence: 99%

Effect of Regular Sauna on Epidermal Barrier Function and Stratum Corneum Water-Holding Capacity in vivo in Humans: A Controlled Study

Kowatzki¹,

Macholdt²,

Krull³

et al. 2008

Dermatology

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During the last few years, sauna has become the epitome of wellness. Besides studies in general medicine evaluating the health benefit of sauna, e.g. on the cardiovascular system, no systematic study regarding skin physiology has been published. The present exploratory study was intended to analyse the effect of regular Finnish sauna on skin physiology. The effect of regular sauna bathing was assessed with non-invasive instruments: stratum corneum water-holding capacity, skin redness, transepidermal water loss and surface skin pH were analysed in 41 healthy volunteers, aged 20–49 years, in a group with regular sauna exposure compared to a control group with no regular sauna exposure. A more stable epidermal barrier function, an increase in stratum corneum hydration, a faster recovery of both elevated water loss and skin pH after exposure to 2 × 15 min sauna at 80°C could be demonstrated in volunteers with regular sauna. Heart beat rate and ionic concentration in sweat as well as epidermal blood perfusion showed a training effect under regular sauna. A decrease in casual skin sebum content on the skin surface of the forehead was observed in these volunteers. The present data suggest a protective effect of regular sauna on skin physiology, especially surface pH and stratum corneum water-holding capacity.

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Section: Discussionmentioning

confidence: 99%

Effect of Regular Sauna on Epidermal Barrier Function and Stratum Corneum Water-Holding Capacity in vivo in Humans: A Controlled Study

Kowatzki¹,

Macholdt²,

Krull³

et al. 2008

Dermatology

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“…It has been reported that a secreted peptidoglycan of P. acnes stimulates the production of proinflammatory cytokines, such as IL-1, IL-8, and TNF-, by human monocytic cell lines and freshly isolated peripheral blood mononuclear cells from acne patients. [19][20][21][22] In a recently published study, heatkilled P. acnes stimulated THP-1 cells to produce IL-8 and TNF-. 23) Hence, to determine the anti-inflammatory effects of Geumgamja and Cheonyahagyul, we measured IL-8 and TNF-concentrations in THP-1 cells by ELISA.…”

mentioning

confidence: 99%

Biological Activities of KoreanCitrus obovoidesandCitrus natsudaidaiEssential Oils against Acne-Inducing Bacteria

Kim

Baik

et al. 2008

Bioscience, Biotechnology, and Biochemistry

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“…30,31 Recently, it has also been described that P. acnes triggers anti-microbial peptide and cytokine secretion of keratinocytes in vitro. [23][24][25] P. acnes, itself, is able to induce cytokines-like such as TNFa, IL-1a and IL-8. 26,27 Moreover the genome sequence of P. acnes is known to encode many factors that may have inflammatory potential.…”

Section: Discussionmentioning

confidence: 99%

“…[23][24][25][26][27][28][29] In this context, we hypothesized that P. acnes is able to increase CRH expression by keratinocytes, representing a local stress in acne. We thus evaluated the modulation of CRH also described.…”

Section: Introductionmentioning

confidence: 99%

Cutaneous induction of corticotropin releasing hormone byPropionibacterium acnesextracts

Isard

Knol

Castex‐Rizzi

et al. 2009

Dermato-Endocrinology

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The skin commensal bacillus Propionibacterium acnes is known to play a major role in the development of acne vulgaris and it is established that this bacteria is involved both in the induction and maintenance of the inflammatory phase of acne. The corticotropin releasing hormone (CRH), a neuropeptide originally isolated from the hypothalamus, is also produced by the skin. CRH has been reported to play a role in the inflammation, the production of sebum and finally the differentiation of keratinocytes. At the therapeutic level, zinc is known to act specifically on inflammatory lesions with still partially known mechanisms and thus could play an important role in the development of inflammatory acne lesions. Our objective was to study the modulation of CRH expression by keratinocytes induced by P. acnes extracts. CRH expression was examined using immunohistochemistry technique on deepfrozen sections of normal human skin explants incubated with two different extracts of P. acnes and with or without zinc salts. We observed that the membrane fraction (FM) of P. acnes increased the CRH expression in the epidermis. This result indicates that P. acnes, by stimulating the production of CRH, can both modulate the differentiation of keratinocytes and increase the local inflammation, arguing that this bacterium plays a role not only in the development of inflammatory acne lesions but also in the formation of the microcomedo in the early stages of acne.

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Induction of a chemoattractive proinflammatory cytokine response after stimulation of keratinocytes with Propionibacterium acnes and coproporphyrin III

Abstract: This cytokine pattern may favour a chemotactic response and implicates P. acnes and coproporphyrin III in the recruitment of inflammatory cells to the site of infection and in the development of acne lesions.

Cited by 100 publications

References 19 publications

Effect of Regular Sauna on Epidermal Barrier Function and Stratum Corneum Water-Holding Capacity in vivo in Humans: A Controlled Study

Effect of Regular Sauna on Epidermal Barrier Function and Stratum Corneum Water-Holding Capacity in vivo in Humans: A Controlled Study

Biological Activities of KoreanCitrus obovoidesandCitrus natsudaidaiEssential Oils against Acne-Inducing Bacteria

Cutaneous induction of corticotropin releasing hormone byPropionibacterium acnesextracts

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