Induction of apoptosis by c9, t11-CLA in human endometrial cancer RL 95-2 cells via ERα-mediated pathway

Wang, Jihui; Xiao, Lanbo; Zhang, Xiaojuan; Liu, Jing; Ye, Shuhong; Xiao, Shan; Chen, Hongzhou; Han, Wei

doi:10.1016/j.chemphyslip.2013.07.009

Cited by 16 publications

(12 citation statements)

References 26 publications

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“…VA is also anti‐inflammatory because it alters immune cell surface molecular profile and reduces the production of pro‐inflammatory cytokines . Anti‐cancer and immune modulation effects have been reported in studies of cis ‐9, trans ‐11 CLA as well .…”

Section: Introductionmentioning

confidence: 98%

Trans‐11 vaccenic acid improves insulin secretion in models of type 2 diabetes in vivo and in vitro

Gupta

Kerslake

Rayat

et al. 2016

Molecular Nutrition Food Res

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Section: Introductionmentioning

confidence: 98%

Trans‐11 vaccenic acid improves insulin secretion in models of type 2 diabetes in vivo and in vitro

Gupta

Kerslake

Rayat

et al. 2016

Molecular Nutrition Food Res

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“…Solid and dashed lines indicate the stimulatory and inhibitory actions, respectively. CLA, conjugated linoleic acid; ERα, estrogen receptor α; ERE, estrogen response element; PP2A, protein phosphatase 2A (Chujo and others ; Tanmahasamut and others ; Liu and Sidell ; Miglietta and others , 2006b; Bocca and others ; Song and others ; Wang and others ).…”

Section: Cla In the Prevention Of Menopausal Symptomsmentioning

confidence: 99%

“…Along with breast cancer, it has been recently demonstrated that ER‐positive endometrial cancer could be suppressed by CLA isomer (Wang and others ). In this study, cis ‐9, trans ‐11 CLA triggered apoptosis in human endometrial cancer cells partly via ERα‐mediated pathway, whereas no effect was observed with trans ‐10, cis ‐12 isomer.…”

Section: Cla In the Prevention Of Menopausal Symptomsmentioning

confidence: 99%

“…Based on previous reports that CLA has been shown to inhibit ER‐positive breast and endometrial cancer through the regulation of ERα‐mediated signaling (Chujo and others ; Tanmahasamut and others ; Liu and Sidell ; Bocca and others ; Wang and others ), the potential of CLA as a SERM has been explored. In combination treatment of CLA with 17β‐estradiol (E2), the trans ‐10, cis ‐12 CLA inhibited MCF‐7 cell proliferation induced by E2, whereas cis ‐9, trans ‐11 CLA had no inhibitory effect with E2 stimulation (Chujo and others ).…”

Section: Cla and Selective Estrogen Receptor Modulatormentioning

confidence: 99%

“…CLA plays a variety of preventive roles against chronic diseases including cancer, atherosclerosis, obesity, and osteoporosis (Pariza ; Dilzer and Park ). In particular, there has been increasing evidence demonstrating that CLA has positive effects with regard to health issues associated with menopause including inhibition of estrogen receptor (ER) signaling in human endometrial and breast cancer cells (Aro and others ; Brownbill and others ; Liu and Sidell ; Raff and others ; Kanaya and Chen ; Wang and others ; Rahman and others ). This suggests the potential beneficial role of CLA in postmenopausal women.…”

Section: Introductionmentioning

confidence: 99%

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Conjugated Linoleic Acid and Postmenopausal Women's Health

Kim¹,

Kim²,

Park

2015

Journal of Food Science

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Declined estrogen levels in women after menopause can cause a number of significant health issues, and various estrogen receptor ligands have been clinically evaluated for postmenopausal treatment. Conjugated linoleic acid (CLA) has been shown to display protective effects against menopausal symptoms such as bone loss and metabolic dysfunctions in both animals and humans. In particular, it inhibits the proliferations of breast and endometrial cancer cells through estrogen receptor α-mediated mechanism(s). These findings suggest that CLA may provide beneficial effects on menopausal symptoms, while protecting the endometrium and breast from estrogen stimulation. Thus, understanding the effects of CLA on menopausal disorders and ER metabolism is important in development of novel therapeutic options for use in postmenopausal women with or without conventional estrogen therapy. In this report, we review literature regarding the impact of CLA on menopausal symptoms in cell lines, rodents, and humans, along with potential mechanism(s). We also discuss safety consideration for CLA use in humans.

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Estrogen receptor alpha activates MAPK signaling pathway to promote the development of endometrial cancer

Zhang²,

Yang³

et al. 2019

J of Cellular Biochemistry

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Endometrial cancer (EC) is a common malignant tumor of the female reproductive system in the world. For most of the treated patients, although the survival rate is improved, most patients still have a poor prognosis. The pathogenesis of EC has always been a strong scientific focus, but there is no clear conclusion. Therefore, in view of modularization, this study is to conduct an in‐depth analysis on the effects of estrogen receptor alpha (ERα) regarding EC. The purpose is to identify the molecular course of EC. We obtained 10 co‐expression modules, in which ANO2, EMP3, and other genes are significantly differentially expressed in patients with EC. Additionally, there are active regulatory effects in dysfunction modules, thus genes such as ANO2 and EMP3 would be identified as key genes, which are associated with the development of EC. Enrichment results showed that the module genes were significantly involved in RNA splicing, covalent chromatin modification, histone modification, and organelle fission, and other biological processes, as well as significantly regulated mitogen‐activated protein kinases (MAPK) signaling pathway, Endocytosis, Rap1 signaling pathway, and viral carcinogenesis, and other signaling pathways. Finally, we identified noncoding RNA pivot including FENDRR, miR‐520c‐3p. Besides, transcription factors pivot including NFKB1, E2F1, and RELA which significantly regulate dysfunction module genes. Overall, our work deciphered a co‐expression network involving differential gene regulation in ERα‐associated EC. It helps reveal the core modules and potential regulatory factors of the diseases and enhances our understanding of the pathogenesis. More importantly, we revealed that ERα activates the MAPK signaling pathway to promote the development of EC. It helps to provide a new reference for later research.

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Induction of apoptosis by c9, t11-CLA in human endometrial cancer RL 95-2 cells via ERα-mediated pathway

Cited by 16 publications

References 26 publications

Trans‐11 vaccenic acid improves insulin secretion in models of type 2 diabetes in vivo and in vitro

Trans‐11 vaccenic acid improves insulin secretion in models of type 2 diabetes in vivo and in vitro

Conjugated Linoleic Acid and Postmenopausal Women's Health

Estrogen receptor alpha activates MAPK signaling pathway to promote the development of endometrial cancer

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