Induction of ferroptosis using functionalized iron-based nanoparticles for anti-cancer therapy

Synergistic Effect of Ferroptosis‐Inducing Nanoparticles and X‐Ray Irradiation Combination Therapy

“…We examined the effect of combination therapy using X‐ray irradiation with hyaluronic acid‐based nanoparticles with Fe (FHA‐NPs), which are safe particles that induce ferroptotic cell death that were previously reported in detail elsewhere regarding their clinical application ( Figure ). [ 18 ] We observed a correlation between the experimental results and those of the Monte Carlo simulations. FHA‐NPs are internalized through the high affinity between HA and the ligand of the CD44, cancer overexpression receptor; followed by degradation by hyaluronidase in lysosomes, the generation of lipid ROS, and, finally the ferroptotic cell death via lipid peroxidation.…”

“…Therefore, to develop a treatment through ferroptosis in cancer nanomedicine, research on the possibility and performance of anticancer treatment using nanoparticles, as well as research on the mechanism of ferroptosis are continuously and actively being reported. [18][19][20][21][22][23] In clinical cancer treatment, X-rays are a commonly and widely used radiation therapy and have remained one of the standard cancer treatments for decades because of their good effectiveness. In fact, 50% of cancer patients receive radiation therapy, and even though it is the cornerstone of cancer treatment, complete response to cancer treatment is still challenging due to radiation resistance, remarking the necessity for radiosensitizers.…”

“…Therefore, to develop a treatment through ferroptosis in cancer nanomedicine, research on the possibility and performance of anticancer treatment using nanoparticles, as well as research on the mechanism of ferroptosis are continuously and actively being reported. [ 18–23 ]…”

Clonogenic assay and computational modeling using real cell images to study physical enhancement and cellular sensitization induced by metal nanoparticles under MV and kV X-ray irradiation

“…A detailed explanation related to the preparation process and FHA NP characterization may be found elsewhere. 38 GNPs with a mean diameter of 106 ± 8 nm were purchased from Sigma-Aldrich (St. Louis, MO, USA).…”

Research Progress on Ferroptosis as a Therapeutic Strategy in Renal Cell Carcinoma

“…With the development of materials science, more and more studies suggest that nanoparticles can induce ferroptosis including lung cancer, breast cancer, liver cancer and other tumor cells [47,48]. Nanoparticles in combination with small molecular ferroptosis induction agents have the advantages of solubility, targeted enhancement, low systemic toxicity, controllable drug control, and synergy advantage in emerging combination therapies [49].…”