Induction of retinal regeneration in vivo by growth factors

Park, Carol M.; Hollenberg, Martin J.

doi:10.1016/0012-1606(91)90341-y

Cited by 108 publications

(44 citation statements)

References 29 publications

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“…FGF-1, FGF-2, or FGF-8 can all induce retinogenesis in the pigmented epithelium (Park and Hollenberg, 1991;Pittack et al, 1991Pittack et al, , 1997. By contrast, activin can block retinal regeneration from the pigmented epithelium, even in the presence of FGF (Pittack and Reh, unpublished observations).…”

Section: A C Bmentioning

confidence: 99%

“…Further studies showed that a source of FGF-1 can be substituted for the piece of neural retina (Park and Hollenberg, 1991). Retinal regeneration from the CMZ in the embryonic avian eye proceeds quickly, and evidence of regeneration can be seen as early as one day after removal of the retina.…”

Section: Regeneration Of Retina From the Cmzmentioning

confidence: 99%

“…Retinal regeneration from the CMZ in the embryonic avian eye proceeds quickly, and evidence of regeneration can be seen as early as one day after removal of the retina. Recent work has shown that FGF-2 and Sonic hedgehog are independently sufficient to induce regeneration from the CMZ after retinectomy (K. Del Rio-Tsonis, personal communication), while other known retinal mitogens such as TGF-β, insulin, IGF-1, and IGF-2 are each insufficient (Park and Hollenberg, 1991).…”

Section: Regeneration Of Retina From the Cmzmentioning

confidence: 99%

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Retinal stem cells and regeneration

Moshiri¹,

Close²,

Reh³

2004

Int. J. Dev. Biol.

150

122

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The optic vesicle gives rise to several very different epithelial tissues, including the neural retina, the pigmented epithelium, the iris, the ciliary epithelium of the ciliary body and the optic stalk. Retinal regeneration can arise from several different cellular sources; in some species, the process involves interconversion, or transdifferentiation, among cells of the different tissue types. Therefore, prior to a discussion of retinal regeneration, we will briefly discuss current knowledge about the influence of signaling molecules in cell fate determination in ocular tissues. Next, we will detail the evidence for neurogenesis in the mature retina. Lastly, we will describe various types of regenerative phenomena that occur in the retina, from complete regeneration of functional retina in fish and amphibians, to the more limited neuronal production that occurs in avian and mammalian retinas.

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Section: A C Bmentioning

confidence: 99%

Section: Regeneration Of Retina From the Cmzmentioning

confidence: 99%

Section: Regeneration Of Retina From the Cmzmentioning

confidence: 99%

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Retinal stem cells and regeneration

Moshiri¹,

Close²,

Reh³

2004

Int. J. Dev. Biol.

150

122

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“…Rather, the FGFs may mimic another surface ectodermal ligand by activating the FGF receptor tyrosine kinase signaling pathway. However, no other known ligand is capable of causing RPEto-NR transdifferentiation (including EGF, insulin, NGFβ, IGF1, IGFII and TGFβ1) (Nguyen and Arnheiter, 2000;Park and Hollenberg, 1991;Pittack et al, 1991), although EGF can substitute for FGF or surface ectoderm to organize the OV (Nguyen and Arnheiter, 2000). We suggest, therefore, that FGFs or other unidentified molecule(s) organize the OV by activating Chx10, which then represses Mitf.…”

Section: Chx10mentioning

confidence: 99%

Chx10repression ofMitfis required for the maintenance of mammalian neuroretinal identity

et al. 2005

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During vertebrate eye development, the cells of the optic vesicle (OV)become either neuroretinal progenitors expressing the transcription factor Chx10, or retinal pigment epithelium (RPE) progenitors expressing the transcription factor Mitf. Chx10 mutations lead to microphthalmia and impaired neuroretinal proliferation. Mitf mutants have a dorsal RPE-to-neuroretinal phenotypic transformation, indicating that Mitfis a determinant of RPE identity. We report here that Mitf is expressed ectopically in the Chx10or-J/or-J neuroretina(NR), demonstrating that Chx10 normally represses the neuroretinal expression of Mitf. The ectopic expression of Mitf in the Chx10or-J/or-J NR deflects it towards an RPE-like identity; this phenotype results not from a failure of neuroretinal specification, but from a partial loss of neuroretinal maintenance. Using Chx10 and Mitf transgenic and mutant mice, we have identified an antagonistic interaction between Chx10 and Mitf in regulating retinal cell identity. FGF (fibroblast growth factor) exposure in a developing OV has also been shown to repress Mitf expression. We demonstrate that the repression of Mitfby FGF is Chx10 dependent, indicating that FGF, Chx10 and Mitf are components of a pathway that determines and maintains the identity of the NR.

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“…Regeneration of the NR from the RPE can be induced by impknting a piece of NR into the vitreous chamber (Coulombre and Coulombre, 1970). The effect of NR impknts on regeneration is mimicked by impknting blocks of ethyelene/vinyl coacetate polymer impregnated with FGF-2 or, at higher concentrations, FGF-1 (Park and Hollenberg, 1991). The polarity of the regenerated neural retina is reversed in both cases; i.e.…”

Section: Dediffekntiation/tmnsde Terminationmentioning

confidence: 99%

Rx for tissue restoration: Regenerative biology and medicine

Stocum¹

2001

Korean Journal of Biological Sciences

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Induction of retinal regeneration in vivo by growth factors

Cited by 108 publications

References 29 publications

Retinal stem cells and regeneration

Retinal stem cells and regeneration

Chx10repression ofMitfis required for the maintenance of mammalian neuroretinal identity

Rx for tissue restoration: Regenerative biology and medicine

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