Induction of substantial myocardial regeneration by an active fraction of the Chinese herb Rosa laevigata Michx

Abstract

BackgroundThe replacement of lost cardiac tissues by regenerated myocardium would be a therapeutic ideal for myocardial infarction. The objective of this study was therefore to evaluate the ability of an active fraction that was isolated from Rosa laevigata Michx in therapeutic cardiomyogenesis in a myocardial infarction rat model.MethodsThe myocardial infarction animal model was induced by the permanent ligation of the left anterior descending coronary artery in rats. The active fraction, which improves the survival rate and prevents ischemic reperfusion damage, was used to test the therapeutic effect of this fraction on myocardial infarction.ResultsThe oral administration of the active fraction for 4 weeks could progressively restore the decreased cardiac function due to myocardial infarction. The significantly improved cardiac function was probably attributed to the active fraction-induced myocardial regeneration, which replaced the lost cardiac tissues in the myocardial infarction animals.ConclusionsThe property of this active fraction appears to be entirely novel and may provide a potential therapeutic alternative for myocardial infarction.

Traditional uses, phytochemical, pharmacology, quality control and modern applications of two important Chinese medicines from Rosa laevigata Michx.: A review

“… Jia et al (2012) demonstrated the protective effects of TFs in R. laevigata against hydrogen peroxide-induced injury in human umbilical vein endothelial cells. Qu et al (2015) established a myocardial infarction (MI) rat model to study the ability of the active ingredients of R. laevigata in the treatment of this condition. The results showed oral administration of the active ingredients to MI-induced animals gradually restored the decline in cardiac function caused by MI and induced the myocardial regeneration and replacement of necrotic heart tissues.…”

Rosa laevigata Attenuates Allergic Asthma Exacerbated by Water-Soluble PM by Downregulating the MAPK Pathway

“…Rosa laevigata (RL), which is mainly distributed in southern China and Asia, belongs to the Rosaceae family. RL fruit is edible and has been used in traditional medicine for the treatment of various diseases, including kidney disease and diarrhea ( Qu et al, 2015 ). According to recent research, numerous lignans with antioxidant activity and compounds such as flavonoids, saponins, and tannins have been isolated from the fruits of RL ( Li et al, 2012 ; Zhang et al, 2013d ; Dong et al, 2015 ).…”