Induction of Virus Ribonucleic Acids in Non-permissive MSV-IF + Cells Infected with NDV

Abstract

SUMMARYMouse cells (MSV-IF+) are completely non-permissive to NDV; however, they produce interferon when NDV is used as an inducer. Eight h after infection these cells synthesize a virus 'minus' strand RNA which anneals to the extent of 57 to 97 % with virus 'plus' strand RNA. This synthesis disappears gradually up to 48 h after infection, and is not modified by the incubation temperature (37 °C or 40 °C) of the infected cells.