Induction Therapy and Methods of Preventing the Development of Bronchopleural Fistula in Locally Advanced Forms of Non-Small Cell Lung Cancer

Abstract

This review is devoted to the urgent problem of modern oncology - combined treatment of locally advanced lung cancer with neoadjuvant chemotherapy, chemoradiation, targeted therapy. Literature data on the influence of various variants of neoadjuvant therapy on the development of postoperative bronchopleural complications, risk factors, methods of their prevention are analyzed in detail. The role of primary and secondary plastics of the stump of the main bronchus, tracheobronchial anastomoses with various autoflaps is highlighted. The article analyzes the data of large meta-analyzes and works originating from specialized clinics dealing with this problem.