Induction to inhalation anaesthesia in agamid lizards with alfaxalone

Abstract

ABSTRACT:The aim of this study was to evaluate intravenous anaesthesia with alfaxalone for tracheal tube insertion in three species of agamid lizards. Alfaxalone, at a dose rate of 5 mg/kg, was administered intravenously to 80 inland bearded dragons (Pogona vitticeps), 10 Rankin's dragons (Pogona henrylawsoni) and 10 Chinese water dragons (Physignathus cocincinus) following 24 h of fasting. The righting reflex in inland bearded dragons, Rankin's dragons and Chinese water dragons was lost within 12-45 s (17.52 ± 8.80 s), 15-40 s (24.60 ± 9.61 s) and 12-40 s (21.70 ± 9.53 s), respectively. The mean tracheal tube insertion time for inland bearded dragons, Rankin's dragons and Chinese water dragons was 23.61 ± 10.91 s, 35.30 ± 14.71 s and 32.00 ± 14.32 s, respectively. Intravenous use of alfaxalone proved to be a suitable method for safe tracheal tube insertion and induction to inhalation anaesthesia in agamid lizards.

Effect of a GnRH agonist (deslorelin) on ovarian activity in leopard geckos (Eublepharis macularius)

“…The general anaesthesia of female leopard geckos using the combination of meloxicam with tramadol, alfaxalone and isoflurane was uneventful; which is in accordance with our previous experiences with alfaxalone anaesthesia in reptiles, including lizards (Knotek 2017). Our previous studies were focused on the clinical use of GnRH implants (deslorelin) in young female green iguanas and veiled chameleons.…”

Surgical removal of an atypical histiocytic cell proliferation in a bearded dragon (Pogona vitticeps)

“…The injection anesthetic alfaxalon has been frequently used as an induction agent in a variety of species. For bearded dragons, doses ranging from 5 to 15 mg/kg have been described, depending on the route of administration [26,27]. Since in the present case, venous access was available prior to inducing anesthesia, alfaxalon was administered at 5 mg/kg IV and resulted in a smooth induction.…”

Alfaxalona como alternativa para indução anestésica de cães e gatos durante a pandemia de Covid-19: revisão bibliográfica / Alfaxalone as an alternative for anesthetic induction in dogs and cats during the Covid-19 pandemic: literature review

“…Essa modulação potencia o efeito do GABA endógeno e consequentemente aumento da condutância de cloreto na célula resultando em Brazilian Journal of Development, Curitiba, v.7, n.11, p. 105123-105133 nov. 2021 hiperpolarização da membrana pós-sináptica e inibição do potencial de propagação neuronal, similar aos benzodiazepínicos (WARNE et al, 2015;EL-HAWARI et al, 2017). Em concentrações mais altas, a alfaxalona exerce um efeito como agonista GABA, similar ao propofol e aos barbitúricos (WARNE et al, 2015;KNOTEK, 2017;PERRIN et al, 2017;BRADLEY et al, 2019;BERTELSEN et al, 2021).…”