Industrial radiotracer application in flow rate measurement and flowmeter calibration using 99mTc and 198Au nanoparticles radioisotope

Yunos, Mohd Yazid Mohd; Hussain, Siti Aslina; Sipaun, Susan Maria

doi:10.1016/j.apradiso.2018.10.008

Cited by 8 publications

(1 citation statement)

References 12 publications

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“…Accordingly, this reduces production costs, enhances process efficiency, and improves product quality [ 2 , 3 , 5 ]. Notably, 99m Tc received considerable attention in multi-disciplinary fields due to its accessible availability and favorable nuclear properties, such as its short half-life of 6.01 h and the emission of low-energetic photons (140 keV) [ 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 ]. 99m Tc is widely available from 99 Mo/ 99m Tc radionuclide generators.…”

Section: Introductionmentioning

confidence: 99%

Developing a Chromatographic 99mTc Generator Based on Mesoporous Alumina for Industrial Radiotracer Applications: A Potential New Generation Sorbent for Using Low-Specific-Activity 99Mo

et al. 2022

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The commercial low-pressure column chromatographic 99Mo/99mTc generator represents a reliable source of onsite, ready-to-use 99mTc for industrial applications. These generators use fission-produced 99Mo of high specific activity, posing serious production challenges and raising proliferation concerns. Therefore, many concepts are aimed at using low-specific-activity (LSA) 99Mo. Nonetheless, the main roadblock is the low sorption capacity of the used alumina (Al2O3). This study investigates the feasibility of using commercial alumina incorporated with LSA 99Mo to develop a useful 99Mo/99mTc generator for industrial radiotracer applications. First, the adsorption profiles of some commercial alumina sorbents for LSA 99Mo were tested under different experimental conditions. Then, the potential materials to develop a 99Mo/99mTc generator were selected and evaluated regarding elution yield of 99mTc and purity. Among the sorbents investigated in this study, mesoporous alumina (SA-517747) presented a unique sorption-elution profile. It demonstrated a high equilibrium and dynamic sorption capacity of 148 ± 8 and 108 ± 6 mg Mo/g. Furthermore, 99mTc was eluted with high yield and adequate chemical, radiochemical, and radionuclidic purity. Therefore, this approach provides an efficient and cost-effective way to supply onsite 99mTc for radiotracer applications independent of fission-produced 99Mo technology.

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