PurposeThe purpose of this paper is to investigate the research landscape of LSS 4.0 papers published in two well-known repositories, Scopus and Web of Science (WoS), in terms of publication trends, article distribution by author, journal, affiliations and country, and article clustering based on keywords, authors and countries. In addition, a literature review was carried out to build a conceptual framework of integrated Lean Six Sigma and Industry 4.0 (LSS 4.0) that encompasses operational, sustainability and human factors or ergonomics aspects.Design/methodology/approachThe literature review of integrated Lean Six Sigma and I4.0 publications published in Scopus and WoS databases in the current decade was conducted for the present study. This study categorizes LSS, I4.0 and related research articles based on publication patterns, journals, authors and affiliations, country and continental-wise distribution and clustering the articles based on keywords and authors from the Scopus and WoS databases from 2011 to 2022 using the search strings “Lean”, “Six Sigma”, “Lean Six Sigma” and “Industry 4.0” in the Title, Abstract and Keywords using Biblioshiny, VOS viewer and Microsoft Excel.FindingsIn the recent three years, from 2020 to 2022, LSS 4.0 has been substantially increasing and is seen as an emerging and trending area. This research identifies the most influential authors, most relevant affiliations, most prolific countries and most productive journals and clusters based on keywords, authors and countries. Further, a conceptual framework was developed that includes the impact of operational, sustainability and ergonomic or human factors in LSS 4.0.Research limitations/implicationsThis article assists in comprehending the trends and patterns of LSS 4.0. Further, the conceptual framework helps professionals and researchers understand the significance and impact of integrating LSS and Industry 4.0 in the aspects of human factors/ergonomic, sustainability and operations. Also, the research induce professionals to incorporate all these factors while designing and implementing LSS 4.0 in their organization.Originality/valueThis conceptual framework and bibliometric analysis would aid in identifying potential areas of research and providing future directions in the domain of LSS 4.0. It will be beneficial for academicians, professionals and researchers who are planning to apply and integrate techniques of LSS and technologies of I4.0 in their organizations and research.