Inescapable shock induces the opposite changes of the plus-maze test behavior in rats with divergent coping strategy

Zhukov, D. A.; Vinogradova, Katherine P.

doi:10.1016/0031-9384(94)90346-8

Cited by 19 publications

(4 citation statements)

References 29 publications

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“…19, NO. 5 Stress Responses to an Anxiolytic in Rats Bred for Anxiety 391 this kind of correlation has not been found (Viglinskaya et al 1995;Zhukov and Vinogradova 1994), and we should always keep in mind that in some strains and lines, there is even a lack of correlation between the behavioral performance in different tests of emotionality (Chaouloff et al 1994;Overstreet et al 1996;Ramos et al 1997;Zhukov and Vinogradova 1994). In the present experiment, the same differential behavioral patterns in the forced-swim test as seen in our previous study were observed in HAB and LAB rats regardless of drug treatment; namely, higher immobility scores, less struggling, and a shorter latency to floating in HAB rats (Figure 2).…”

Section: Discussionmentioning

confidence: 99%

Behavioral, Physiological, and Neuroendocrine Stress Responses and Differential Sensitivity to Diazepam in Two Wistar Rat Lines Selectively Bred for High- and Low-Anxiety–Related Behavior

Liebsch

Linthorst

Neumann

et al. 1998

Neuropsychopharmacology

150

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Two Wistar rat lines, selectively bred for high-anxietyrelated behavior (HAB) and low-anxiety-related behavior (LAB) in the elevated plus-maze test, were tested for the susceptibility of their behavioral characteristics to anxiolytic treatment and for their endocrine and physiological reactivity to different stressors. Injection of 1mg/kg diazepam failed to affect line differences in coping strategy but resulted in a marked (20-fold) Genetic factors contribute to the high interindividual variability in type and/or intensity of the behavioral, neuroendocrine, and physiological stress responses observed in various species, including humans and laboratory rats (Boissy 1995;Clément et al. 1997;Cools et al. 1990;Curé and Rolinat 1992;Prasad et al. 1996;Spanagel et al. 1995;Tesser 1993;Zuckerman 1993). This fact has been used as the basis for selective bidirectional breeding programs from which strains and lines differing in their behavioral and/or neuroendocrine reFrom the Max Planck Institute of Psychiatry, Munich, Germany. Address correspondence to: Dr. R. Landgraf, Max Planck Institute of Psychiatry, Kraepelinstr. 2, 80804 Munich, Germany.Received January 15, 1997; revised March 25, 1998; accepted April 16, 1998. 382 G. Liebsch et al. N EUROPSYCHOPHARMACOLOGY 1998 -VOL . 19 , NO . 5 sponses to environmental challenges have emerged (Brush 1991;Castanon and Mormède 1994;Cools et al. 1993;Gentsch et al. 1988;Walker et al. 1992). Recently, we reported the establishment of two Wistar rat lines selectively bred for differing behavioral performances in the elevated plus-maze test, now termed high-anxiety-related behavior (HAB) and low-anxiety-related behavior (LAB) lines, respectively ). This animal model of inborn anxiety provides the advantage of avoiding conditioned stimuli that by themselves are likely to trigger behavioral, neuroendocrine, and physiological alterations. Interestingly, the HAB and LAB animals also prefer different coping strategies in a forced swim test ), pointing toward a link between anxiety and coping with stressful situations.The elevated plus-maze test is based on the creation of a conflict between the exploratory drive of a rat and its innate fear of open, exposed areas. It is one of the most widely used nonconditioned animal models of anxiety and has been extensively validated pharmacologically and ethologically (Dawson and Tricklebank 1995;Pellow 1986;Pich et al. 1993). However, various clinically effective anxiolytic substances often yield contradictory results when administered to "normal" unstressed rats in this test (Griebel 1995;Rodgers et al. 1997), indicating that-in parallel to the situation in humans (Green and Hodges 1991; Lader 1991)-the efficacy of an anxiolytic may depend upon the animal's basal level of anxiety. To test this prediction and to characterize further our breeding lines, in the first experiment, male rats from the HAB and LAB lines were injected with a classical anxiolytic, diazepam, and submitted to a plus-maze test and a forced swim test to assess the e...

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Section: Discussionmentioning

confidence: 99%

Behavioral, Physiological, and Neuroendocrine Stress Responses and Differential Sensitivity to Diazepam in Two Wistar Rat Lines Selectively Bred for High- and Low-Anxiety–Related Behavior

Liebsch

Linthorst

Neumann

et al. 1998

Neuropsychopharmacology

150

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“…Long-term amygdala-kindled rats display increases in open-arm exploration and open-arm jumps in the plus-maze, concomitant with heightened fear responses in other animal models of anxiety (Kalynchuk, 2000; Kalynchuk et al, 1997). Also, prior exposure to either severe or chronic intermittent stressors during adulthood increases rats' open-arm exploration while exacerbating fear-related responding in other tests (D'Aquila, Brain, & Willner, 1994; Renard, Suarez, Levin, & Rivarola, 2005; Zhukov & Vinogradova, 1994).…”

Section: Discussionmentioning

confidence: 99%

Repeated exposure to stress across the childhood-adolescent period alters rats' anxiety- and depression-like behaviors in adulthood: The importance of stressor type and gender.

Pohl

Olmstead

Wynne‐Edwards

et al. 2007

Behavioral Neuroscience

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This research tests the hypothesis that specific forms of adversity in early life map onto behavioral signs analogous to depression versus anxiety in later life. Male and female rats were exposed to either severe sporadic stress or chronic mild stress during the childhood-adolescent period, and their behavior was tested in adulthood. Males in the severe sporadic stress group showed exaggerated anxiety-related behaviors, as indicated by increases in shock-probe burying and escape-like responses (jumps) from the open arms of the elevated plus-maze. Females exposed to severe sporadic stress displayed no change in burying behavior but did display increases in escape behavior. These same females also exhibited behaviors analogous to depression that manifested as decreased sucrose consumption. The chronic mild stress regime produced effects only in females, including reduced burying, decreased sucrose consumption, and an exaggerated corticosterone response to cold-water immersion stress. Findings reiterate the importance of early life experience to the development of adult psychopathologies and emphasize the need to consider both the type of early experience and gender differences in these analyses.

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“…Koltushi High Avoidance (KHA) and Koltushi Low Avoidance (KLA) rat strains have been developed based on selective breeding at Pavlov Institute of Physiology from Wistar rats using divergent performances in avoidance conditioning in two-way shuttle-boxes during five consecutive days as the criterion (Ryzhova et al 1983). KHA and KLA strains of rats demonstrate different levels of anxiety (Zhukov, Vinogradova 1994). In the present study the females of 46 th and 47 th generation of the selection were used.…”

Section: название разделаmentioning

confidence: 99%

Progesterone and anxiety during the oestrus cycle in rats genetically selected for high and low active avoidance

Zhukov

Арутюнян

Vinogradova

2020

Integrative Physiology

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In this research, the changes of anxiety and blood progesterone levels during the oestrus cycle were studied in rats genetically selected for high (KHA) and low (KLA) acquisition of active avoidance. Anxiety levels were measured by the time spent in open arms of the elevated plus-maze. Progesterone levels were determined by radioimmunoassay. KLA rats exhibited no significant changes in anxiety levels during the oestrus cycle. KHA rats showed a significant variation of anxiety during the oestrus cycle with a high level in the diestrus phase and a low level in proestrus. Moreover, anxiety in diestrus in KHA rats was higher than in KLA rats. Additionally, increased progesterone levels were observed in KLA rats in comparison with the KHA strain, during both diestrus and proestrus. Anxiety levels corresponded to plasma progesterone during the oestrus cycle in both rat strains.

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Inescapable shock induces the opposite changes of the plus-maze test behavior in rats with divergent coping strategy

Cited by 19 publications

References 29 publications

Behavioral, Physiological, and Neuroendocrine Stress Responses and Differential Sensitivity to Diazepam in Two Wistar Rat Lines Selectively Bred for High- and Low-Anxiety–Related Behavior

Behavioral, Physiological, and Neuroendocrine Stress Responses and Differential Sensitivity to Diazepam in Two Wistar Rat Lines Selectively Bred for High- and Low-Anxiety–Related Behavior

Repeated exposure to stress across the childhood-adolescent period alters rats' anxiety- and depression-like behaviors in adulthood: The importance of stressor type and gender.

Progesterone and anxiety during the oestrus cycle in rats genetically selected for high and low active avoidance

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