Infantile gliosarcoma: a case and a review of the literature

Abstract

The literature concerning gliosarcomatous tumors is reviewed, and pathological and clinical features of the tumor are briefly discussed.

Childhood’s gliosarcomas: pathological and therapeutical considerations on three cases and critical review of the literature

“…Okami et al [22] found just eight cases of gliosarcoma in children published in the literature, to which we can add the radio-induced one described by Malde et al [16], the three described by Sarkar et al [32], and the three described in this study.…”

Infantile gliosarcoma

“…Since the first reports published by Stroebe in 1895, more than 100 cases of gliosarcoma have been reported, eight of which were in children 1 . Gliosarcoma accounts for 1.8 to 8% of all glioblastomas 1 .…”

“…Some authors claim that metastases are rare, while others report that they occur in up to one third of cases, principally in the lungs, pleura, lymph nodes, bone marrow, liver, spinal cord, kidney and peripancreatic areas 6,7 . The role of chemo-and radiotherapy in the treatment of gliosarcoma remains to be defined, although some authors believe that these adjuvant forms of therapy are important, particularly in the case of children 1,8 . We describe an infantile case of gliosarcoma after the authorization of the parents.…”

“…Gliosarcoma accounts for 1.8 to 8% of all glioblastomas 1 . It is classified by the World Health Organization (WHO) as a grade IV tumor and is composed of malignant glial and mesenchymal tissue [2][3][4] .…”

“…In children, the tumor may appear as an extensive cystic mass. It is important to differentiate gliosarcoma from meningioma in which there is more homogeneity with contrast enhancement and less edema 1,7 . Magnetic resonance imaging (MRI) shows a hyperintense lesion with irregular contrast enhancement at T1.…”