Infecção e doença pelos vírus linfotrópicos humanos de células T (HTLV-I/II) no Brasil

Carneiro-Proietti, Anna Bárbara F.; Ribas, João Gabriel Ramos; Catalan-Soares, Bernadette; Martins, Marina Lobato; Brito-Melo, Gustavo Eustáquio Alvim; Martins‐Filho, Olindo Assis; Pinheiro, S. R.; Araújo, Abelardo de Queiroz-Campos; Galvão–Castro, Bernardo; Oliveira, Maria Santos; Guedes, Antônio Carlos Martins; Proietti, Fernando Augusto

doi:10.1590/s0037-86822002000500013

Cited by 101 publications

(112 citation statements)

References 31 publications

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“…The asymmetric distribution of HTLV-1/2 prevalence in blood donors in different regions of the State of Minas Gerais is similar to findings reported by Catalan-Soares 2 in different Brazilian states and is classically referred to as the tendency for clustering of this infection, as observed in other areas of the world, such as Japan and the Caribbean 1,19,20 . The study by Catalan-Soares 2 verified lower HTLV reactivity in the southern region of Brazil, intermediate positivity in the State of Minas Gerais (southeastern region of Brazil) and higher rates in the States of Pernambuco, Bahia and Maranhão, all in the northeastern region of Brazil 19 .…”

Section: Discussionsupporting

confidence: 84%

“…The study by Catalan-Soares 2 verified lower HTLV reactivity in the southern region of Brazil, intermediate positivity in the State of Minas Gerais (southeastern region of Brazil) and higher rates in the States of Pernambuco, Bahia and Maranhão, all in the northeastern region of Brazil 19 . In this study, higher reactivity was verified in the screening test for HTLV in the metropolitan area of Belo Horizonte and a lower prevalence in the south of the state.…”

Section: Discussionmentioning

confidence: 91%

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Decline in prevalence and asymmetric distribution of human T cell lymphotropic virus 1 and 2 in blood donors, State of Minas Gerais, Brazil, 1993 to 2007

Dias-Bastos

Oliveira

Carneiro-Proietti

2010

Rev. Soc. Bras. Med. Trop.

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Introduction: Human T cell lymphotropic virus types 1 and 2 (HTLV-1/2) are endemic in Brazil and are screened for in transfusion services since 1993. This study evaluated the evolution of the prevalence of HTLV-1 and 2 in blood donors of the Hemominas Foundation from 1993 to 2007, and its geographical distribution in State of Minas Gerais, Brazil. Methods: The Hemominas Foundation is a centralized blood center in Minas Gerais, Brazil. The sources of data were the Hemominas Foundation Technical Bulletin and files from the centralized serological laboratory. Donors were tested in the period using enzyme linked immuno sorbent assays (ELISA), followed by Western blot, when repeatedly reactive. The data were analyzed by EPIINFO 6.2 and TABWIN 3.5 softwares. Results: The average seroprevalence in the period 1993-2007 was 0.1%. A steady decline occurred from 0.4% in 1993 to below 0.1% in 2002 and later, with a transient peak of 0.5% in 1994. HTLV reactivity distribution was asymmetrical in the state, with regions of higher prevalence, interspersed with low prevalence areas. Comparison of positive and negative donors verified that increasing age was proportional to virus positivity. Odds ratio for age ranged from 1.43 (30 to 39 years-old) to 3.09 (50 to 65 years-old). Women had a greater chance of being positive (OR-1.64), as previously described. Conclusions: Possible explanations for HTLV-1/2 prevalence decline are the exclusion of positive donors from the donor pool, an increase in repeat donors and ELISA test improvement, with reduction in the number of false positive results.

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Section: Discussionsupporting

confidence: 84%

Section: Discussionmentioning

confidence: 91%

Decline in prevalence and asymmetric distribution of human T cell lymphotropic virus 1 and 2 in blood donors, State of Minas Gerais, Brazil, 1993 to 2007

Dias-Bastos

Oliveira

Carneiro-Proietti

2010

Rev. Soc. Bras. Med. Trop.

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“…[17][18][19][20] Syndromes that are part of the neurological complex related to HTLV-1 have a distinct pathogenic substrate from adult T-cell leukemia/lymphoma (ATL). 2 It is also not entirely clear how HTLV resists a competent immune system or what determines risk of development of the diseases associated with it. HAM/TSP is an immunomediated disease, 21 related to the host's immunoresponse to infection.…”

Section: Transmissionmentioning

confidence: 99%

O vírus linfotrópico de células T humanos tipo 1 (HTLV-1): Quando suspeitar da infecção?

Romanelli¹,

Caramelli²,

Proietti³

2010

Rev. Assoc. Med. Bras.

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“…These results are consistent with previous estimates of 10-20 million infected individuals 8 . In Brazil alone, an estimated 2.5 million people are infected, which is most likely the largest number of seropositive individuals in a single country 9 .…”

Section: Introductionmentioning

confidence: 99%

Sexual transmission of human T-cell lymphotropic virus type 1

Paiva

Casseb

2014

Rev. Soc. Bras. Med. Trop.

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Human T-cell lymphotropic virus type 1 (HTLV-1) is endemic in many parts of the world and is primarily transmitted through sexual intercourse or from mother to child. Sexual transmission occurs more effi ciently from men to women than women to men and might be enhanced by sexually transmitted diseases that cause ulcers and result in mucosal ruptures, such as syphilis, herpes simplex type 2 (HSV-2), and chancroid. Other sexually transmitted diseases might result in the recruitment of infl ammatory cells and could increase the risk of HTLV-1 acquisition and transmission. Additionally, factors that are associated with higher transmission risks include the presence of antibodies against the viral oncoprotein Tax (anti-Tax), a higher proviral load in peripheral blood lymphocytes, and increased cervicovaginal or seminal secretions. Seminal fl uid has been reported to increase HTLV replication and transmission, whereas male circumcision and neutralizing antibodies might have a protective effect. Recently, free virions were discovered in plasma, which reveals a possible new mode of HTLV replication. It is unclear how this discovery might affect the routes of HTLV transmission, particularly sexual transmission, because HTLV transmission rates are signifi cantly higher from men to women than women to men.

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Infecção e doença pelos vírus linfotrópicos humanos de células T (HTLV-I/II) no Brasil

Cited by 101 publications

References 31 publications

Decline in prevalence and asymmetric distribution of human T cell lymphotropic virus 1 and 2 in blood donors, State of Minas Gerais, Brazil, 1993 to 2007

Decline in prevalence and asymmetric distribution of human T cell lymphotropic virus 1 and 2 in blood donors, State of Minas Gerais, Brazil, 1993 to 2007

O vírus linfotrópico de células T humanos tipo 1 (HTLV-1): Quando suspeitar da infecção?

Sexual transmission of human T-cell lymphotropic virus type 1

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