Infecciones concurrentes por dos serotipos del virus dengue durante un brote en el noroeste de Perú, 2008

Abstract

This is the first Peruvian report of patients with concurrent infections of two DENV serotypes without severe clinical manifestations.

Epidemiological Characteristics of Dengue Disease in Latin America and in the Caribbean: A Systematic Review of the Literature

“…In the Andean region, all dengue virus serotypes were reported to circulate [34]; DENV-3 predominated from 1999 to 2010 [35, 39–42], peaking in 2008 where it accounted for 46.6% of dengue cases [35]. DENV-2 predominated in 2011 (41% of all dengue cases analyzed) [36] and cocirculated mainly with DENV-1 [40, 41].…”

“…Other studies found that the risk for severe dengue was increased in patients under the age of 15 years, those with a history of dengue [35], and those needing repeated treatment for recurrent dengue symptoms [44], demonstrating that dengue was more common and generally more severe in young people [36]. …”

“…While dengue affects all age groups, available data on burden or severity of dengue by age group in Latin America and English-speaking and Hispanic Caribbean Islands are inconsistent, with some studies suggesting a greater burden or severity of disease among children [25, 35, 36, 44] and others suggesting the burden or severity of disease to be the same or higher among older children (aged ≥ 15 years) and adults [37, 57]. In Southeast Asia, where dengue has been circulating for much longer, there is evidence of an increase in the incidence of dengue towards older age groups [90] and that this age shift has led to dengue primarily affecting the adult population in some countries [91].…”

Circulación de un linaje diferente del virus dengue 2 genotipo América / Asia en la región amazónica de Perú, 2010

“…Para el año 2000, los cuatro serotipos de DENV estaban circulando en el noroeste de Perú, así como en otras regiones tropicales, se informaron miles de casos de DC y casos de DH/SCD, se aislaron los cuatro serotipos del virus dengue y se determinó la circulación de dos genotipos del DENV-2, el americano nativo y el genotipo América -Asia (3)(4)(5)(6)(7)(8)(9)(10) .…”

Molecular detection of mixed infections with multiple dengue virus serotypes in suspected dengue samples in Tamaulipas, Mexico

“…In Mexico, Torres-Galicia et al (2014) reported that consecutive infections with DENV-1 / DENV-2, DENV-3 / DENV-2 or DENV-4 / DENV-2 serotypes are also associated with DHF. Another study in Peru reported mixed infections of the following serotype combinations: DENV-1 / DENV-2, DENV-1 / DENV 3, DENV-1 / DENV-4, DENV-2 / DENV-3, DENV-2 / DENV-4, DENV-3 / DENV -4, DENV-1 / DENV-2 / DENV-3 and DENV-1 / DENV-3 / DENV-4 (Mamani et al 2010). Recently, Reddy et al (2017) reported multiple dengue infection in 26 samples obtained in India.…”