Infection and disease in human schistosomiasis mansoni are under distinct major gene control

Dessein, Alain; Marquet, Sandrine; Henri, Sandrine; Wali, Nasr Eldin M.A El; Hillaire, Dominique; Rodrigues, Virmondés; Prata, Áluízio; Mohamed, Sofia B.; Gharib, Bouchra; Reggi, Max de; Magzoub, M.; Saeed, Osman K.; Abdelhameed, Ahmed; Abel, Laurent

doi:10.1016/s1286-4579(99)80096-3

Cited by 47 publications

(25 citation statements)

References 17 publications

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“…One major gene on chromosome 5q31-q33 controls infection (6, 7). Another major locus controls periportal fibrosis and maps close to IFNGR1 on 6q23 (45). Protection against infection is linked to a Th2 immune response, whereas protection against disease is increased by IFN-␥.…”

Section: Discussionmentioning

confidence: 99%

Analysis of the 5q31-q33 Locus Shows an Association between IL13-1055C/T IL-13-591A/G Polymorphisms and Schistosoma haematobium Infections

Kouriba

Chevillard

Bream

et al. 2005

The Journal of Immunology

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Millions of humans are exposed to schistosome infections, which cause severe kidney and liver disease and 280,000 deaths annually. Th2-mediated immunity is critical to human defenses against this pathogen and susceptibility to infection is controlled by a major genetic locus that includes IL4, IL5, and IL13 genes. These observations led us to evaluate whether certain polymorphisms in IL4, IL5, or IL13 determine schistosome infection. The study was performed in two Dogon villages where Schistosoma haematobium is endemic. Schistosome infections were evaluated by counting eggs and measuring worm Ags in urine. Genetic polymorphisms were determined by restriction enzyme analysis or by primer extension and denaturing high-performance liquid chromatography analysis. Associations were tested using family-based association tests and logistical regression analysis. The alleles IL13-1055C (p = 0.05) and IL13-591A (p = 0.01) are shown, by family-based association test, to be preferentially transmitted to children with the 10% highest infections. A logistic regression analysis that included IL13-1055 G/G, G/T and T/T genotypes, age, gender, and village of residency, applied to the whole study population, showed that subjects bearing the IL13-1055T/T genotype were on average much less infected than individuals with other genotypes. Previous studies on asthma indicated that the IL13-1055T allele increased gene transcription, which is in agreement with the fact that this cytokine enhances resistance to infection by schistosome in humans.

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Section: Discussionmentioning

confidence: 99%

Analysis of the 5q31-q33 Locus Shows an Association between IL13-1055C/T IL-13-591A/G Polymorphisms and Schistosoma haematobium Infections

Kouriba

Chevillard

Bream

et al. 2005

The Journal of Immunology

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“…Both positive and negative associations have been reported. [48][49][50][51] Interpretation of this discrepancy has been extensively discussed and includes the reduction in egg excretion leading to an underestimation of parasite load in patients with periportal fibrosis, the chronic evolution of the disease that does not synchronize morbidity and the peak of infection intensity, and differences on the clinical phenotypes counted as morbidity markers, such as hepatosplenomegaly or fibrosis. We suggest that the intensity of infection, although important in disease progression, is not the only critical factor in the development of fibrosis and other components such as the immune response and host genetic factors may play critical roles.…”

Section: Discussionmentioning

confidence: 99%

High levels of IgG4 to Schistosoma mansoni egg antigens in individuals with periportal fibrosis.

Silveira¹,

Bethony²,

Gazzinelli³

et al. 2002

The American Journal of Tropical Medicine and Hygiene

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“…The susceptibility and response to infection may be under genetic control. 4 The exact mechanisms, however, have not been determined. Posttransmission schistosomiasis has been reported for Schistosoma japonicum, S. mansoni, and S. haematobium.…”

Section: Discussionmentioning

confidence: 99%

Latent Schistosomiasis in Portuguese Soldiers

Miranda

Cerqueira

Delgado³

et al. 2007

Military Medicine

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Schistosomiasis was diagnosed in two Portuguese soldiers who had been deployed to Portuguese colonies in Africa. The first veteran was diagnosed as having schistosomiasis 34 years after returning from Angola, and the second veteran was found with Schistosoma haematobium infection 40 years after returning from Mozambique. The patient with Schistosoma mansoni had an active infection, because eggs were recovered with living miracidia. The second patient had developed urothelial cancer, but eggs recovered were calcified.

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Infection and disease in human schistosomiasis mansoni are under distinct major gene control

Cited by 47 publications

References 17 publications

Analysis of the 5q31-q33 Locus Shows an Association between IL13-1055C/T IL-13-591A/G Polymorphisms and Schistosoma haematobium Infections

Analysis of the 5q31-q33 Locus Shows an Association between IL13-1055C/T IL-13-591A/G Polymorphisms and Schistosoma haematobium Infections

High levels of IgG4 to Schistosoma mansoni egg antigens in individuals with periportal fibrosis.

Latent Schistosomiasis in Portuguese Soldiers

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