Infection control measures to stop the spread of sequence type 15 OXA-23-producing Acinetobacter baumannii in a Swedish Burn Center

Does Emerging Carbapenem Resistance in Acinetobacter baumannii Increase the Case Fatality Rate? Systematic Review and Meta-Analysis

“…In addition to medical advancements on rapid and early detection of the disease and its causative pathogen, a study from 2022 recently evaluated their self-developed method of using enhanced detection systems for healthcare-associated transmission (EDS-HAT) to detect silent outbreaks and identify routes of transmissions with this novel method, which combines whole genome sequencing (WGS) and machine learning (ML) while also highlighting the demand for prompt surveillance and action not only upon diagnosis but also upon healthcare-associated transmissions [59]. Although this newly introduced method appears to be more efficient in detecting outbreaks earlier compared to infection prevention and control measures, recent studies report that regular PPE training and hand hygiene scoring of healthcare workers, environmental screening, clonality surveillance of samples, and modified cleaning procedures are still highly effective in the containment and elimination of nosocomial CRAB infections when applied regularly and in compliance [9,60,61]. Moreover, pulsed-field gel electrophoresis remains the gold standard for surveillance of clonality amongst bacterial isolates, and the application of WGS can be challenging to sustain in terms of costs, standardization of protocols, quality assurance, as well as the interpretation of the results [62].…”