Infection in Infertility

Henkel, Ralf

doi:10.1007/978-1-4614-3335-4_25

Cited by 6 publications

(4 citation statements)

References 133 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…-Infections: Such as sexually transmitted diseases, epididymo-orchitis, urinary tract infections, and mumps infections can cause infertility. Their mechanisms could be attributed to the imbalance between free radicals and antioxidants causing a state of oxidative stress and subsequential increased DNA fragmentation [9] , while chronic and recurrent infections cause fibrosis, scarring, atrophy with possible pathway obstruction, and sperm immaturity. Urinary tract infections prompt specifically cellular and humoral immune system activation [10] , while before childhood vaccinations, mumps orchitis was a prevalent cause of testicular atrophy and abnormal sperm parameters [11] .…”

Section: Medical Historymentioning

confidence: 99%

Precise review of a male's infertility assessment from a men's health specialist prospective

Khalafalla,

Ammar,

Wang

2023

UroPrecision

View full text Add to dashboard Cite

Infertility is a pervasive issue affecting a considerable proportion of couples in their reproductive years, with a projected 10%–15% prevalence. It is characterized by the incapability to achieve conception following a year of consistent, unprotected intercourse, and its far‐reaching consequences can take a profound emotional, psychological, and social toll on couples, inducing feelings of melancholy, exasperation, and anxiety. The appraisal of infertile couples' cases is a multifaceted and daunting process, necessitating a holistic understanding of the intricate underlying factors contributing to their infertility. Consequently, an individualized evaluation should be conducted, considering diverse parameters, such as the couple's medical history, age, infertility duration, and other relevant criteria. This paper will provide an in‐depth overview of the current approaches utilized in the evaluation of men with infertility, including the commonly employed diagnostic tools and procedures. Enhancing our comprehension of infertility assessment and management holds the promise of helping couples achieve their ultimate desire of conceiving and enriching their overall quality of life.

show abstract

Section: Medical Historymentioning

confidence: 99%

Precise review of a male's infertility assessment from a men's health specialist prospective

Khalafalla,

Ammar,

Wang

2023

UroPrecision

View full text Add to dashboard Cite

show abstract

“…In addition, we were surprised by the authors’ statement that our article (Henkel et al., 2020) ‘introduced’ infection as a contributing factor for male infertility. In fact, it has long been known that after idiopathic infertility and varicocele, MGT infections with about 11.6% are the third single most cause of male infertility (Henkel, 2020; Nieschlag & Behre, 1997), and it is generally accepted that these infections are potentially correctable (Weidner et al., 1999).…”

Section: Anti‐inflammatory Effectsmentioning

confidence: 99%

“…However, one should be cautious to assume that improving male fertility is synonymous with improving male infertility, especially in the latter case. First understanding what is the root cause of the MGT inflammation is crucial to resolving the cause of infertility in the male (Henkel, 2020, 2021; Henkel et al., 2020).…”

Section: Serotonin (5‐ht)mentioning

confidence: 99%

Reply to Letter to the Editor by Derakhshan et al. (2021) ‘Vagal nerve stimulation for the treatment of male factor infertility’

Fisher

Henkel

2021

Andrologia

Self Cite

View full text Add to dashboard Cite

“…Studies have shown that OS is one of the major causes of male infertility, especially for those who have unexplained and idiopathic male infertility [1] . OS can not only affect spermatozoa but also can potentially have consequences on a systematic level such as decreasing the amount of testosterone or LH [4] . Increased OS also directly damages sperm DNA, thus compromising the paternal genomic contribution to the embryo [5] .…”

Section: Introductionmentioning

confidence: 99%

Laboratory assessment of oxidative stress in semen

Agarwal

Qiu

Sharma

2018

Arab Journal of Urology

View full text Add to dashboard Cite

ObjectivesTo evaluate different laboratory assessments of oxidative stress (OS) in semen and identify a cost-efficient and highly sensitive instrument capable of providing a comprehensive measure of OS in a clinical setting, as early intervention and an accurate diagnostic test are important because they help maintain a balance of free radicals and antioxidants; otherwise, excessive OS could lead to sperm damage and result in male infertility.Materials and methodsA systematic literature search was performed through a MedLine database search using the keywords ‘semen’ AND ‘oxygen reduction potential’. We also reviewed the references of retrieved articles to search for other potentially relevant research articles and additional book chapters discussing laboratory assessments for OS, ranging from 1994 to 2017. A total of 29 articles and book chapters involving OS-related laboratory assays were included. We excluded animal studies and articles written in languages other than English.ResultsDirect laboratory techniques include: chemiluminescence, nitro blue tetrazolium, cytochrome C reduction test, fluorescein probe, electron spin resonance and oxidation–reduction potential (ORP). Indirect laboratory techniques include: measurement of Endtz test, lipid peroxidation, chemokines, antioxidants/micronutrients/vitamins, ascorbate, total antioxidant capacity, or DNA damage. Each of these laboratory techniques has its advantages and disadvantages.ConclusionTraditional OS laboratory assessments have their limitations. Amongst the prevalent laboratory techniques, ORP is novel and better option as it can be easily used in a clinical setting to provide a comprehensive review of OS. However, more studies are needed to evaluate its reproducibility across various laboratory centres.

show abstract

Infection in Infertility

Cited by 6 publications

References 133 publications

Precise review of a male's infertility assessment from a men's health specialist prospective

Precise review of a male's infertility assessment from a men's health specialist prospective

Reply to Letter to the Editor by Derakhshan et al. (2021) ‘Vagal nerve stimulation for the treatment of male factor infertility’

Laboratory assessment of oxidative stress in semen

Contact Info

Product

Resources

About