2000
DOI: 10.1099/0022-1317-49-11-947
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Infections in AIDS

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Cited by 30 publications
(13 citation statements)
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“…Proteins from these microbes, however, are processed in the phagosome, loaded onto MHCII molecules, and shuttled to the cell surface, marking the infected cells for recognition by CD4 ϩ T cells (22)(23)(24)(25)(26). The importance of this fundamental aspect of antigen presentation is evidenced by that fact that CD4 ϩ T cell-deficient individuals have a preferential susceptibility to phagosomal infections (27,28).…”
Section: T Cell Antigen Receptor Recognition Of Peptide-mhc Ligandsmentioning
confidence: 99%
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“…Proteins from these microbes, however, are processed in the phagosome, loaded onto MHCII molecules, and shuttled to the cell surface, marking the infected cells for recognition by CD4 ϩ T cells (22)(23)(24)(25)(26). The importance of this fundamental aspect of antigen presentation is evidenced by that fact that CD4 ϩ T cell-deficient individuals have a preferential susceptibility to phagosomal infections (27,28).…”
Section: T Cell Antigen Receptor Recognition Of Peptide-mhc Ligandsmentioning
confidence: 99%
“…The primary role of CD8 ϩ T cells in the control of these cytosolic infections is likely related to the efficient production of microbial p:MHCI complexes by infected cells. In contrast, CD4 ϩ T cells are probably the key controllers of primary infections by microbes such as Mycobacterium tuberculosis, Cryptococcus neoformans, Leishmania major, and Salmonella enterica (27), because these organisms replicate in the phagosomes of macrophages and dendritic cells, where p:MHCII complexes are formed (85)(86)(87)(88). Not only are CD4 ϩ T cells the main controllers of these infections (9,21,(89)(90)(91), they also appear to do so with little help from other cells of the adaptive immune system.…”
Section: Cd4 ؉ T Cell Response To Phagosomal Infectionmentioning
confidence: 99%
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“…Previous authors highlight risk factors including human immunodeficiency virus (HIV) infection, extreme youth, malnutrition and malaria [2]. The greatest contributor to disease burden over the past decade is undoubtedly the increase in HIV-NTS co-infection [3,4,5,6] associated with a very high mortality [7,8]. The first report of NTS in an acquired immune deficiency syndrome (AIDS) patient was from Haiti in 1983 [9] and five case reports from New York, United States of America (USA,) all with S. Typhimurium, were reported in 1985 [10].…”
Section: Background To the Increase In Non-typhoidal Salmonellamentioning
confidence: 99%
“…Staphylococcus and Pseudomonas organisms are opportunistic pathogens in humans which can infect the eyes through contaminated fingers/contact lenses. Pseudomonas aeruginosa has emerged as one of the most common causes of gram negative bacteraemia with possible dissemination to the eyes (Adeleye et al, 2008;Hart et al, 2000).…”
mentioning
confidence: 99%