2015
DOI: 10.1016/s2359-3482(15)30044-0
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Infectious complications after surgical splenectomy in children with sickle cell disease

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“…Individuals with SCD exhibit deficiencies in their innate immune system, primarily attributed to reduced splenic function, making them more susceptible to infections caused by encapsulated bacteria, and the compromised innate immune response stems from malfunctions in elements like chemotaxis, migration, and scavenging due to faulty neutrophils, alongside decreased splenic phagocytic filtration and a diminished opsonization capabil-ity [11]. Furthermore, the adaptive immune system in SCD is compromised, characterized by a reduced production of memory B cells and crucial IgM components, essential for the humoral immune system.…”
Section: Immune Dysfunction and Susceptibility To Infectionmentioning
confidence: 99%
“…Individuals with SCD exhibit deficiencies in their innate immune system, primarily attributed to reduced splenic function, making them more susceptible to infections caused by encapsulated bacteria, and the compromised innate immune response stems from malfunctions in elements like chemotaxis, migration, and scavenging due to faulty neutrophils, alongside decreased splenic phagocytic filtration and a diminished opsonization capabil-ity [11]. Furthermore, the adaptive immune system in SCD is compromised, characterized by a reduced production of memory B cells and crucial IgM components, essential for the humoral immune system.…”
Section: Immune Dysfunction and Susceptibility To Infectionmentioning
confidence: 99%