Infectious Complications in the First Year Post Renal Transplantation

Clinical and microbiological epidemiology of early and late infectious complications among solid-organ transplant recipients requiring hospitalization

“…The increase in the burden of infectious complications may be related to the concurrent use of more potent immunosuppressive agents early post‐transplantation along with more aggressive maintenance immunosuppressive strategies to prevent acute graft dysfunction . With a median time from transplantation of 4.2 years, our data describes the clinical burden of infectious complications not only during the early post‐transplant period as previously reported, but also long afterward .…”

“…This is especially true for our lung recipients (including a substantial number of out‐of‐province residents) who had the highest rates of hospitalization for infectious complications. Previous reports confirm this shift in burden from graft failure and cardiovascular disease to infectious disease as a primary cause of hospitalization as well as death during the first year post‐transplantation . The increase in the burden of infectious complications may be related to the concurrent use of more potent immunosuppressive agents early post‐transplantation along with more aggressive maintenance immunosuppressive strategies to prevent acute graft dysfunction .…”

Infection is the chief cause of mortality and non‐death censored graft loss in the first year after renal transplantation in a resource limited population: A single centre study

“…Infection is a major cause of morbidity and mortality after RTX . The incidence and epidemiology of infections in LMICs like India with a high infectious disease burden in the general population is expected to differ from developed, high income nations.…”

“…The incidence and epidemiology of infections in LMICs like India with a high infectious disease burden in the general population is expected to differ from developed, high income nations. There are very few studies that have evaluated the profile and impact of infections specifically in the first year after RTX in LMICs …”

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“…Surgical incision infections (SIIs), along with urinary tract infections, are among the most common infective complications after kidney transplant. 1,2 Meticulous analyses of early and recent reports have shown postoperative wound infection rates in renal trans plant recipients to vary from 2% to 40%, with most studies demonstrating a rate from 4% to 16%. [3][4][5][6][7][8][9][10] Despite this low rate of wound infection in renal transplant recipients, infectious wound complications, when combined with immunosuppression, can be devastating and pose a vexing medical, surgical, and economic problem.…”