Infectious diseases are associated with carotid intima media thickness in adolescence

Dratva, Julia; Caviezel, Seraina; Schaffner, Emmanuel; Bettschart, Robert; Küenzli, Nino; Schindler, Christian; Schmidt‐Trucksäss, Arno; Stolz, Daiana; Zemp, Elisabeth; Probst‐Hensch, Nicole

doi:10.1016/j.atherosclerosis.2015.10.021

Cited by 18 publications

(23 citation statements)

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“…To the best of our knowledge, this study is the first to analyze a possible association of atopic sensitization and allergic diseases with DC and cIMT in adolescents. Whereas evidence points towards an impact of systemic hyper-inflammation due to atopic sensitization on the vascular endothelium, our results do not support this assumption in adolescents [2, 3, 9, 15, 20, 39]. Better knowledge about the impact of the clinical character, main determinants and potential role of disease control of either atopic sensitization or allergic diseases might be valuable.…”

Section: Discussioncontrasting

confidence: 90%

“…Another study found an adverse influence of repeated episodes of common childhood infectious diseases on cIMT [15]. This has also been suspected by Liuba et al in 2005 [9].…”

Section: Discussionmentioning

confidence: 63%

“…The standardized, high-quality measurements of DC and cIMT in a cohort of adolescents was a main strength of our study. Although early structural changes due to chronic systemic inflammation have been reported in children and adolescents [15, 20, 47], one should be aware, that the assessment of functional instead of structural alterations (e.g. by flow-mediated dilation), might lead to earlier detection of increased vascular risk related to atopic sensitization.…”

Section: Discussionmentioning

confidence: 99%

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Is atopic sensitization associated with indicators of early vascular ageing in adolescents?

et al. 2019

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Background Chronic systemic inflammation accelerates early vascular ageing. Atopic sensitization and allergic diseases may involve increased inflammatory activity. This study aimed to assess whether atopic sensitization and allergic diseases were associated with altered vascular biomarkers in Norwegian adolescents. Methods Distensibility coefficient of the common carotid arteries, carotid intima-media thickness and atopic sensitization (serum total and specific IgEs) were assessed in 95 Norwegian adolescents, who participated in the RHINESSA generation study. Symptoms of allergic disease were assessed by an interviewer-led questionnaire. Results Atopic sensitization was found in 33 (34.7%) of the adolescents. Symptomatic allergic disease was found in 11 (33.3%) of those with atopic sensitization. Distensibility coefficient of the common carotid arteries appeared to be lower in participants with atopic sensitization than in those without (46.99±8.07*10 −3 /kPa versus 51.50±11.46*10 −3 /kPa; p >0.05), while carotid intima-media thickness did not differ between these groups (0.50±0.04mm versus 0.50±0.04mm; p >0.05). Crude, as well as age- and sex-adjusted multiple regression, revealed no significant association, neither of atopic sensitization nor of allergic disease, with distensibility coefficient of the common carotid arteries and carotid intima-media thickness. Conclusions Our results do not support the assumption of an adverse impact of atopic sensitization and/or allergic disease on distensibility coefficient of the common carotid arteries and carotid intima-media thickness in Norwegian adolescents. Further research is necessary to study whether the clinical severity of allergic diseases might be more important than the status of allergic disease or atopic sensitization.

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Section: Discussioncontrasting

confidence: 90%

“…Another study found an adverse influence of repeated episodes of common childhood infectious diseases on cIMT [15]. This has also been suspected by Liuba et al in 2005 [9].…”

Section: Discussionmentioning

confidence: 63%

Section: Discussionmentioning

confidence: 99%

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Is atopic sensitization associated with indicators of early vascular ageing in adolescents?

et al. 2019

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“…The health examination consisted of measurements of weight (SECA877 flat scale; SAPALDIA3&4), height (SECA206, wall-fixed measuring system; SAPALDIA3&4), hip and waist circumference (SECA201 ergonomic measuring tape, SECA, Reinach, Switzerland; SAPALDIA3&4), bio-impedance analysis (BIA) using two different devices (Helios, Forana GmbH, Frankfurt, Germany (SAPALDIA3&4 Tanita MC-780MA, TANITACorporation, Tokyo, Japan; SAPALDIA4), blood pressure and heart rate measurements (Omron MC6 or Omron 705-IT, Anandic Medical Systems AG, Bern Switzerland; SAPALDIA3&4); non-fasting blood glucose (only measured at SAPALDIA3); diagnostics for HbA1c and triglycerides (SAPALDIA4: point-of-care diagnostics from capillary blood: Afinion AS100 Analyzer; ALERE, Wädenswil, Switzerland; SAPALDIA3: analysis of venous blood) [ 30 , 31 ].…”

Section: Methodsmentioning

confidence: 99%

The modifying role of physical activity in the cross-sectional and longitudinal association of health-related quality of life with physiological functioning-based latent classes and metabolic syndrome

Cerletti

Keidel

Imboden

et al. 2020

Health Qual Life Outcomes

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Background Single cardio-metabolic risk factors are each known modifiable risk factors for adverse health and quality of life outcomes. Yet, evidence on the clustered effect of these parameters and the metabolic syndrome (MetS) on health-related quality of life (HRQoL) is still limited and mostly cross-sectional. The objectives of this study were to identify clusters of cardio-metabolic physiological functioning, to assess their associations with HRQoL in comparison with the MetS, to elucidate the modifying role of physical activity, and to assess differences in health service utilization. Methods This study is based on longitudinal data from two time points (2010/11 & 2017/18) of the Swiss Study on Air Pollution and Lung and Heart Diseases (SAPALDIA). Latent class analysis (LCA) grouped participants based on a priori selected cardio-metabolic and MetS related physiological functioning variables (Body mass index, body fat, glycated hemoglobin, blood triglycerides, blood pressure). The 36-item Short-Form Health Survey (SF-36) was used to assess HRQoL. Quantile regressions were performed with and without adjustment for physical activity, to detect independent associations of the latent classes, MetS and physical activity with HRQoL. To assess the modifying role of physical activity, we additionally grouped participants based on the combination of physical activity and latent classes or MetS, respectively. Logistic regressions were used to investigate health service utilization as outcome. Results The LCA resulted in three classes labeled “Healthy” (30% of participants in 2017/18), “At risk” and “Unhealthy” (29%). The Unhealthy class scored lowest in all physical component scores of HRQoL. Compared to healthy and active participants, inactive participants in the “Unhealthy” class showed lower scores in the physical functioning domain both cross-sectionally (− 9.10 (− 12.02; − 6.18)) and longitudinally. This group had an odds ratio of 2.69 (1.52; 4.74) for being hospitalized in the previous 12 months. Conclusions These results point to subjects with adverse cardio-metabolic physiological functioning and low activity levels as an important target group for health promotion and maintenance of well-being. The promotion of physical activity at the early stages of aging seems pivotal to mitigate the impact of the MetS on HRQoL at higher age.

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“…Появились данные, что перенесенная в детстве инфекционно-воспалительная патология тесно ассоциирована с госпитализациями по поводу СС событий, а также с проявлениями доклинического атеросклероза в молодом и среднем возрасте [10,11]. Имеются данные, подтверждающие взаимосвязь детских инфекций и признаков субклинического атеросклероза в молодом возрасте [12]. Относительно вероятных механизмов воздействия ОХИ на артериальную стенку рассматривается отрицательное влияние инфекции на липидный статус, так как острофазовые белки обладают высоким сродством к липидам, тормозят поглощение клетками липопротеидов низкой плотности, способствуя дислипидемии [13].…”

Section: Abstract: Chronic Focal Infection Vascular Stiffness Youngunclassified

Indicators of myocardial function in the presence of decompensated chronic tonsillitis

Evsevyeva¹,

Eremin²,

Italantseva³

et al. 2020

Medical news of the North Caucasus

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Рекомендации Российской гастроэнтерологической ассоциации и Ассоциации колопроктологов России по диагностике и лечению взрослых больных язвенным колитом. Российский журнал гастроэнтерологии, гепатологии, колопроктологии. 2015;1:48-65. [Ivash-kin V. T., Sheligin Yu. A., Khalif I. L. [et al.]. Recommendations of the Russian gastroenterological Association and the Association of coloproctologists of Russia on the diagnosis and treatment of adult patients with ulcerative colitis.

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Infectious diseases are associated with carotid intima media thickness in adolescence

Cited by 18 publications

References 50 publications

Is atopic sensitization associated with indicators of early vascular ageing in adolescents?

Is atopic sensitization associated with indicators of early vascular ageing in adolescents?

The modifying role of physical activity in the cross-sectional and longitudinal association of health-related quality of life with physiological functioning-based latent classes and metabolic syndrome

Indicators of myocardial function in the presence of decompensated chronic tonsillitis

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