Infectious encephalitis: Management without etiological diagnosis 48 hours after onset

Fillâtre, Pierre; Crabol, Yoann; Morand, Patrice; Piroth, Lionel; Honnorat, Jérôme; Stahl, J.-P.; Lecuit, Marc

doi:10.1016/j.medmal.2017.02.004

Cited by 22 publications

(11 citation statements)

References 206 publications

(249 reference statements)

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“…11 The introduction of management guidelines for cases of acute encephalitis syndrome over the last decade has aimed to improve outcomes. 8,[13][14][15][16][17][18][19] Notably, there are many differences between guidelines in the approach to diagnostic evaluation, such as standard and extended diagnostic testing, or whether to administer empirical Aciclovir. 20 These variations may reflect geographically contrasting aetiologies, timing of publication and the rapid acceleration of technologies, as well as available resources.…”

Section: Introduction Deficits In the Current Management Of Encephalitismentioning

confidence: 99%

Encephalitis diagnosis using metagenomics: application of next generation sequencing for undiagnosed cases

Brown¹,

Bharucha²,

Breuer³

2018

Journal of Infection

213

179

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There is increasing evidence of a role for NGS in the work-up of undiagnosed encephalitis. Lower costs and increasing accessibility of these technologies will facilitate larger studies of these patients. We recommend NGS should be considered as a front-line diagnostic test in chronic and recurring presentations and, given current sample-to-result turn-around times, as second-line in acute cases of encephalitis.

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Section: Introduction Deficits In the Current Management Of Encephalitismentioning

confidence: 99%

Encephalitis diagnosis using metagenomics: application of next generation sequencing for undiagnosed cases

Brown¹,

Bharucha²,

Breuer³

2018

Journal of Infection

213

179

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“…Tiek VZV, tiek HSV su kel ti en ce fa li tai imu no sup re si jos me tu ga li pa si reikð ti be leu ko ci tø skai èiaus pa di dë ji mo likvo re [7,11,14,20]. Lik vo ro PGR dël VZV pa si þy mi kur kas ma þes niu jaut ru mu nei HSV PGR ty ri mas, to dël kai ku rie au to riai re ko men duo ja kar tu at lik ti ir lik vo ro an ti kûnø prieð VZV ty ri mà, ta èiau iki ðiol në ra ga lu ti nio su ta ri mo dël kon kre èios VZV en ce fa li to nu sta ty mo me to di kos ir tyri mø in ter pre ta ci jos [21].…”

Section: Infekcinio Encefalito Pasireiðkimas Ir Ligos Sukëlëjø Diagnounclassified

“…Ci to me ga lo vi ru so (CMV) su kel tas en ce fa li tas be veik ið skir ti nai ið si vys to tik imu no sup re si niams li go niams [21]. Ri zi ka su sirg ti CMV en ce fa li tu ypaè ið au ga li go niams po kau lø èiul pø transp lan ta ci jos, uþ si krë tu siems ÞIV ir tiems, ku riems tai ko ma gal vos sme ge nø na vi kø ra dio te ra pi ja [22].…”

Section: Infekcinio Encefalito Pasireiðkimas Ir Ligos Sukëlëjø Diagnounclassified

“…HHV-6 ge bë ji mas in tegruo tis á ðei mi nin ko làs te liø ge ne ti nae me dþia gà ir glo ba lus ðio vi ru so pa pli ti mas ap sun ki na HHV-6 en ce fa li to la bo rato ri nae diag nos ti kà. Su kë lë jui nu sta ty ti ir diag no zei pa tvirtin ti siû lo ma ma tuo ti ne tik lik vo ro, bet ir krau jo HHV-6 DNR ly gá, ku ris tu rë tø bû ti ma þes nis nei 6,0 log 10 ko pijø/ml, sie kiant at mes ti chro mo so mo se in teg ruo tos vi ru so DNR re pli ka ci jà, ku ri në ra kli nið kai reikð min ga [21,27].…”

Section: Infekcinio Encefalito Pasireiðkimas Ir Ligos Sukëlëjø Diagnounclassified

“…PML me tu lik vore gliu ko zës kon cen tra ci ja ati tin ka nor mà, daþ niau siai nusta to mas nor ma lus leu ko ci tø skai èius, re tai -vi du ti nið kai pa di dë jaes [37]. Jei lik vo ro JCV PGR yra ne igia mas, diagno zë pa tvir ti na ma at lie kant sme ge nø biop si jà ir his to lo gi ná bei mo le ku li ná biop ta to ið ty ri mà [8,21].…”

Section: Infekcinio Encefalito Pasireiðkimas Ir Ligos Sukëlëjø Diagnounclassified

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Infectious encephalitis diagnosis and treatment in immunosupressed patients: a case report and review of literature

Jokubaitis¹,

Valaikienė²

2019

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Vilniaus universiteto Medicinos fakultetas, Klinikinës medicinos instituto Neurologijos centrasÁVADAS Nau jau sios li te ra tû ros duo me ni mis, en ce fa li to daþ nis siekia iki 12,6 at ve jo 100 000 gy ven to jø per me tus, apie 50 % jø yra in fek ci nës kil mës, 20-30 % -au to imu ni niai, li kaene nu sta ty tos etio lo gi jos [1][2][3]. Pran cû zi jo je at lik to perspek ty vi nio ty ri mo duo me ni mis, daþ niau si in fek ci nio ence fa li to su kë lë jai yra Her pes sim plex vi ru sas (HSV) (42 %), Varicella zoster vi ru sas (VZV) (15 %), My co bacte rium tu ber cu lo sis (15 %) ir Lis te ria monocytogenes (10 %) [4]. Bû din gi kli ni ki niai en ce fa li to po þy miai yra karð èia vi mas, nau jai at si ra dae trau ku liai ir þi di ni në neu rolo gi në simp to ma ti ka [1]. Imu no sup re si niø (angl. immunosuppressed) li go niø cen tri nës ner vø sis te mos (CNS) in fekci jø diag nos ti ka yra su dë tin ga, nes jiems mi në ti kli ni ki niai simp to mai ir po þy miai ga li ne pa si reikð ti, o la bo ra to ri niai ir in stru men ti niai duo me nys -bû ti ne ti pi niai [5]. Ne re tai imu no sup re si niø li go niø in fek ci nio en ce fa li to su kë lë jai yra ne bû din gi imu no kom pe ten ti niams (angl. immunocompetent) as me nims, o imu no sup re si niø li go niø, ser gan èiø in fek ci niu en ce fa li tu, mir tin gu mas yra di des nis, ly gi nant su imu no kom pe ten ti niais, ne pri klau so mai nuo li gos su këlë jo [6,7]. Dvi di dþiau sios imu no sup re si niø, kar tu ir di delës in fek ci nio en ce fa li to ri zi kos, li go niø gru pës yra ser gantie ji on ko lo gi në mis li go mis ir li go niai, var to jan tys imu nosup re si nius vais tus [5].ATVEJO APRAÐYMAS 62 m. vy ras sku biai at veþ tas á ar ti miau sià in sul to cen trà dël ry te pa ste bë to kal bos su tri ki mo. Neu ro lo gi nës ap þiû ros me tu nu sta ty ta da li në sen so mo to ri në afa zi ja ir leng vo laips nio de ði nio ji he mi pa re zë. At li kus sku bià gal vos smege nø kom piu te ri nae to mog ra fi jà (GSKT), ûmiø pa ki ti mø ne nu sta ty ta. Diag no zuo tas ûmus gal vos sme ge nø in sul tas 98 NEUROLOGIJOS SEMINARAI • ISSN 1392-3064 / eISSN 2424-5917 © Neurologijos seminarai, 2019. Open Ac cess. This ar ti cle is dis trib uted un der the terms of the Cre ative Com mons At tri bu tion 4.0 Inter na tional Li cense CC-BY 4.0 (http://creativecommons.org/licenses/by/4.0/), which per mits un re stricted use, dis tri bu tion, and re produc tion in any me dium, pro vided you give ap pro pri ate credit to the orig i nal au thor(s) and the source, pro vide a link to the Cre ative Com mons li cense, and in di cate if changes were made. KLINIKINIS ATVEJISNeurologijos seminarai 2019; 23(80): 98-105 Santrauka. In fek ci nis en ce fa li tas imu no sup re si niø bûk liø me tu yra ne re tai pa si tai kan ti, grei tos diag nos ti kos ir anks ty vo gy dy mo rei ka lau jan ti bûk lë, ga lin ti sà ly go ti sun kø neu ro logi ná de fi ci tà ir net li go nio mir tá. Ði pro ble ma tam pa itin ak tu a li di dë jant ser ga mu mui on ko logi në mis ir au to ...

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Tuberculous Encephalitis

Stahl¹

2019

Extrapulmonary Tuberculosis

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Infectious encephalitis: Management without etiological diagnosis 48 hours after onset

Cited by 22 publications

References 206 publications

Encephalitis diagnosis using metagenomics: application of next generation sequencing for undiagnosed cases

Encephalitis diagnosis using metagenomics: application of next generation sequencing for undiagnosed cases

Infectious encephalitis diagnosis and treatment in immunosupressed patients: a case report and review of literature

Tuberculous Encephalitis

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