Infectious Keratitis After Ocular Surface Stem Cell Transplantation

Cheung, Albert Y.; Sarnicola, Enrica; Eslani, Medi; Kurji, Khaliq; Genereux, Brad M.; Govil, Amit; Holland, Edward J.

doi:10.1097/ico.0000000000001690

Cited by 10 publications

(6 citation statements)

References 37 publications

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“…This is comparable to an epidemiologic study of bacterial keratitis from Vancouver, Canada [ 11 ], but is much higher compared to the reports of infectious keratitis from northern California (17.7%) [ 12 ], and southern Texas (17.6%) [ 10 ]. The ocular surface disease impairs the defense mechanisms of the external eye and cornea, moreover, the decreased integrity of the corneal epithelium, persistent epithelial defects, and associated corneal inflammation can contribute to the increased risk of infectious keratitis in these patients [ 13 , 14 ].…”

Section: Discussionmentioning

confidence: 99%

Citrobacter keratitis: predisposing factors and clinical characteristics

Soleimani

Masoumi

Tabatabaei

et al. 2023

J Ophthal Inflamm Infect

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Purpose To report predisposing factors, clinical presentation, antibiotic sensitivity, and management of Citrobacter-caused infectious keratitis. Methods We retrospectively reviewed the medical records of culture-proven cases of Citrobacter keratitis in a tertiary referral center for 8 years (from January 2012 to September 2020). Demographic data of the patients, predisposing factors, and presenting signs were extracted. Results Eighteen cases of microbial keratitis due to Citrobacter spp. were identified. The median age of the patients was 66 years (range: 10–89, interquartile range : 59–81). Thirteen patients were male and 5 were female. Multiple predisposing factors were identified in all eyes, including ocular surface disease (n = 8), previous corneal surgery (n = 6), and history of ocular trauma (n = 6). Five patients were diabetic. Corrected distance visual acuity (CDVA) of patients was light perception (LP) in 8 patients, hand motion (HM) in 7, counting fingers (CF) at 1 m in 1, and CF at 2 m in 2 patients. Thirteen eyes exhibited hypopyon. An area of corneal thinning was observed in 7 eyes (38.9%). Endophthalmitis due to infectious keratitis developed in one patient. In vitro susceptibility testing confirmed high sensitivity to ceftazidime and aminoglycosides. Medical management consisted primarily of topical amikacin (20 mg/ml) combined with topical cefazoline (50 mg/ml) (72.2%). Surgical tectonic procedures were carried out in 7 eyes (38.9%). Conclusion Citrobacter spp. is a rare cause of bacterial keratitis.Previous keratoplasty and ocular surface problems are important risk factors. The prognosis is not good and surgical tectonic intervention is required in many cases to resolve the corneal infection.

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Section: Discussionmentioning

confidence: 99%

Citrobacter keratitis: predisposing factors and clinical characteristics

Soleimani

Masoumi

Tabatabaei

et al. 2023

J Ophthal Inflamm Infect

View full text Add to dashboard Cite

show abstract

“…This is comparable to an epidemiologic study of bacterial keratitis from Vancouver, Canada 12 , but is much higher compared to the reports of infectious keratitis from northern California (17.7%) 10 , and southern Texas (17.6%) 11 . The ocular surface disease impairs the defense mechanisms of the external eye and cornea, moreover, the decreased integrity of the corneal epithelium, persistent epithelial defects, and associated corneal in ammation can contribute to the increased risk of infectious keratitis in these patients 13,14 .…”

Section: Discussionmentioning

confidence: 99%

Citrobacter keratitis: Predisposing factors and clinical characteristics

Soleimani

Masoumi

Tabatabaei

et al. 2022

Preprint

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Purpose: To report predisposing factors, clinical presentation, antibiotic sensitivity, and management of Citrobacter-caused infectious keratitis. Methods: We retrospectively reviewed the medical records of culture-proven cases of Citrobacter keratitis in a tertiary referral center for 8 years (from January 2012 to September 2020). Demographic data of the patients, predisposing factors, and presenting signs were extracted. Results: Eighteen cases of microbial keratitis due to Citrobacter spp. were identified. The median age of the patients was 66 years (range: 10-89, interquartile range : 59-81). Thirteen patients were male and 5 were female. Multiple predisposing factors were identified in all eyes, including ocular surface disease (n=8), previous corneal surgery (n=6), and history of ocular trauma (n=6). Five patients were diabetic. Corrected distance visual acuity (CDVA) of patients was light perception (LP) in 8 patients, hand motion (HM) in 7, counting fingers (CF) at 1meter in 1, and CF at 2meters in 2 patients. Thirteen eyes exhibited hypopyon. An area of corneal thinning was observed in 7 eyes (38.9%). Endophthalmitis due to infectious keratitis developed in one patient. In vitro susceptibility testing confirmed high sensitivity to ceftazidime and aminoglycosides. Medical management consisted primarily of topical amikacin (20 mg/ml) combined with topical cefazoline (50 mg/ml) (72.2%). Surgical tectonic procedures were carried out in 7 eyes (38.9%). Conclusion: Citrobacter spp. is a rare cause of bacterial keratitis.Previous keratoplasty and ocular surface problems are important risk factors. The prognosis is not good and surgical tectonic intervention is required in many cases to resolve the corneal infection.

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“…Cheung et al reported the rate of infectious keratitis to be 18.7%. 26 Occasional epithelial shedding and breakdown, disturbances in precorneal tear film composition and stability, and altered ocular surface defense mechanisms are of probable risk factors for the development of bacterial keratitis after KLAL. These become especially important when follow-up duration is high, which increases risk of transplanted LSC failure.…”

Section: Discussionmentioning

confidence: 99%