Infectious synovitis in Turkeys: Isolation of tenosynovitis virus‐like agent

Levisohn, Sharon; Gur‐Lavie, A.; Weisman, J.

doi:10.1080/03079458008418380

Cited by 28 publications

(13 citation statements)

References 3 publications

(2 reference statements)

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“…In 1980s, TRVs were isolated from arthritic joints of turkeys (Levisohn et al, 1980;Page et al, 1982;Al Afaleq and Jones, 1990). After this, subsequent reports of arthritis-associated reoviruses in turkeys were lacking.…”

mentioning

confidence: 97%

Phylogenetic analysis, genomic diversity and classification of M class gene segments of turkey reoviruses

Mor

Marthaler

Verma

et al. 2015

Veterinary Microbiology

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mentioning

confidence: 97%

Phylogenetic analysis, genomic diversity and classification of M class gene segments of turkey reoviruses

Mor

Marthaler

Verma

et al. 2015

Veterinary Microbiology

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“…In this report a virus, referred to as virus arthritis agent, was associated with swelling and oedema of hock joint, wing joint and digital flexor tendons. Lameness associated with a reovirus in turkeys was first described in 1980 in 15-week-old turkeys with tenosynovitis/arthritis, in which reovirus was isolated from tendons of affected turkeys (Levisohn et al, 1980). Gross lesions consisted of swollen intertarsal (hock) joints with histological lesions of hyperplastic synovium and inflammatory cell infiltrate in the subsynovium.…”

Section: Viral Tenosynovitis/arthritis Was First Reported In 1968 Inmentioning

confidence: 99%

The role of avian reoviruses in turkey tenosynovitis/arthritis

et al. 2014

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Turkey arthritis reovirus (TARV) has been isolated from the gastrocnemius tendons and tibiotarsal joint fluid of lame male turkeys >12 weeks old in the Midwest. Two experiments were conducted to compare the pathogenicity in turkeys of three TARVs (TARV-MN2, TARV-MN4 and TARV-O'Neil), one turkey enteric reovirus (TERV strain MN1) and one chicken arthritis reovirus (CARV strain MN1). Two hundred microlitres of virus were inoculated by the oral, intratracheal, or footpad route into 6-day-old poults placed in isolator units. Poults were necropsied at 1 and 4 weeks post infection in Experiment 1, and at 2 and 4 weeks post infection in Experiment 2. Reovirus was detected by reverse transcription-polymerase chain reaction and virus isolation in tendons of TARVinoculated poults at 1, 2 and 4 weeks post infection. TARV-O'Neil and TARV-MN2 were detected in tendons of sentinal birds at 1 and 4 weeks and 1 week p.i., respectively. In general, TARVs produced lymphocytic tenosynovitis of the gastrocnemius and digital flexor tendon sheaths without inflammation of the tendons proper. In Experiment 1, poults inoculated with TARV-MN2 and TARV-O'Neil had significantly higher gastrocnemius tendon inflammation scores, as determined by histology, than those inoculated with TERV-MN1 or CARV-MN1. In Experiment 2, poults inoculated with TARV-MN2 and TARV-O'Neil had significantly higher gastrocnemius tendon inflammation scores than those inoculated with TARV-MN4 and virus-free medium (negative control group). Koch's postulates was fulfilled when TARV-MN2 and TARV-O'Neil were re-isolated from tendons of poults that had originally been challenged with either of these viruses. Results of these experiments indicate that TARVs have a unique ability to induce gastrocnemius tenosynovitis in turkeys and that administration of TARV-O'Neil through the oral or intratracheal route is a reproducible model to study pathogenesis of TARV infection.

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“…Certain strains of reovirus are known to cause tenosynovitis (viral arthritis) in chickens (van der Heide 1977;Robertson and Wilcox, 1986), but few reports have been published on the possible association between reoviruses and joint disease in turkeys (Levisohn et al, 1980;Page et al, 1982). Page et al (1982) isolated two reoviruses from tenosynovitis in young turkeys and stated that both viruses 'produced tenosynovitis when injected into the footpad of susceptible day-old poults', but gave no further details.…”

Section: Introductionmentioning

confidence: 99%

Mixed infection of turkeys withMycoplasma synoviaeand reovirus: Field and experimental observations

et al. 1989

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SUMMARYMycoplasma synoviae and a reovirus were isolated from hock joints of commercial turkeys affected with severe synovitis. One day old turkey poults were inoculated with the mycoplasma and the virus into the left and right foot pads respectively. Other groups were given a single infection of either mycoplasma or virus, plus a sham inoculation of sterile medium into the other foot pad. Uninfected controls received sterile medium only. Although the birds were kept for 15 weeks there were no signs of clinical disease and on postmortem examination, there were no gross lesions, apart from occasional slight excess of synovial fluid in the hock joint. Microscopic lesions in the joints were minimal. M. synoviae was recovered only once and this was not until 15 weeks, despite regular attempts to reisolate the organism from a number of tissues, There was serological evidence of M. synoviae infection in some birds, with a greater number of reactors in the dual than the single infection. The virus could be recovered for no more than three weeks from either virus-infected group but neutralising antibodies developed in all birds and persisted until the end of the experiment. Results were similar for the single and dually-infected groups. Factors that may have influenced the outcome of this experiment include the age of bird at infection, the route of infection and possibly the timing of the infections with respect to each other.

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Infectious synovitis in Turkeys: Isolation of tenosynovitis virus‐like agent

Cited by 28 publications

References 3 publications

Phylogenetic analysis, genomic diversity and classification of M class gene segments of turkey reoviruses

Phylogenetic analysis, genomic diversity and classification of M class gene segments of turkey reoviruses

The role of avian reoviruses in turkey tenosynovitis/arthritis

Mixed infection of turkeys withMycoplasma synoviaeand reovirus: Field and experimental observations

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