Inferior Vena Cava Resection and Hemihepatectomy for Leiomyosarcoma, Utilizing Cardiopulmonary Bypass, in Situ Hepatic Perfusion, and Distal Hypothermic Circulatory Arrest

Miles, Lachlan F; Hu, Raymond; Jones, Robert M.; Carson, Scott Alan; McCall, Peter R

doi:10.1053/j.jvca.2015.01.030

Cited by 8 publications

(1 citation statement)

References 27 publications

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“…Other laparotomy incisions used were subcostal incisions (unilateral or bilateral) or a combination of laparotomy and sternotomy. 12,30 For exposure of segment II disease, the standard procedures included kocherization of the duodenum, mobilization of the liver followed by taking control of the vessels. In some situations, segmental resection of the liver was also done to complete an en bloc removal of tumor.…”

Section: Clinical Features and Diagnostic Modalities (Imaging And Tis...mentioning

confidence: 99%

A systematic review of the current management approaches in leiomyosarcoma of inferior vena cava—Results from analysis of 118 cases

Saikia

Rastogi

Barwad

et al. 2021

Asian Cardiovasc Thorac Ann

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Introduction Primary intravenous leiomyosarcomas are rare vascular tumors with aggressive disease biology. The diagnosis and management have been challenging as little data exist from large databases. Methods A literature search was done to identify all cases of primary leiomyosarcomas in the last five years. Clinicopathological features and management strategies were evaluated. Results The median age was 53 years, predominantly females (2.5:1), presenting as metastases in up to 12.1% cases. Most tumors were locally advanced with a median size of 10cm. Inferior vena cava involvement from renal veins to infrahepatic veins remains the most frequent site (57.1%cases) while nearly half (52.8%) proceeded for surgery without histological proof. Most patients could undergo upfront resection (88.0%) with few patients receiving neoadjuvant chemotherapy (4.3%) or neoadjuvant radiotherapy (2.2%). Significant multivisceral resections included right nephrectomy (41.3%), liver resection (25.7%) and left nephrectomy (2.2%). Most patients (91.8%) needed an inferior vena cava graft placement with remarkable microscopically negative margins (85.5% cases). Doxorubicin and ifosfamide were the most frequently used combination chemotherapy regimens in both pre and postoperative settings with partial responses. The median overall and disease free survival among operated patients was 60 months and 28 months respectively. In multivariate analysis large tumor, extensive inferior vena cava involvement, and need for adjuvant chemotherapy appeared significant predictors for overall survival. Conclusions Aggressive upfront surgical resection with clear margin remains the key for long-term survival. Doxorubicin-based regimens were preferred as neoadjuvant chemotherapy while adjuvant treatment with chemotherapy, radiotherapy, or both may be considered in high-risk patients.

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Section: Clinical Features and Diagnostic Modalities (Imaging And Tis...mentioning

confidence: 99%

A systematic review of the current management approaches in leiomyosarcoma of inferior vena cava—Results from analysis of 118 cases

Saikia

Rastogi

Barwad

et al. 2021

Asian Cardiovasc Thorac Ann

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Combined in situ hypothermic liver preservation and cardioplegia for resection of hepatoblastoma with intra-atrial extension in a 3 year old child

Thalhammer

Fanna

Gaudin

et al. 2016

Journal of Pediatric Surgery Case Reports

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Surgical Resection of a Leiomyosarcoma Involving Atrial Reconstruction, Cardiopulmonary Bypass, and Ex-Vivo Liver Resection and Reimplantation

Bunting

Marsh

Wei

et al. 2017

Journal of Cardiothoracic and Vascular Anesthesia

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Inferior Vena Cava Resection and Hemihepatectomy for Leiomyosarcoma, Utilizing Cardiopulmonary Bypass, in Situ Hepatic Perfusion, and Distal Hypothermic Circulatory Arrest

Cited by 8 publications

References 27 publications

A systematic review of the current management approaches in leiomyosarcoma of inferior vena cava—Results from analysis of 118 cases

A systematic review of the current management approaches in leiomyosarcoma of inferior vena cava—Results from analysis of 118 cases

Combined in situ hypothermic liver preservation and cardioplegia for resection of hepatoblastoma with intra-atrial extension in a 3 year old child

Surgical Resection of a Leiomyosarcoma Involving Atrial Reconstruction, Cardiopulmonary Bypass, and Ex-Vivo Liver Resection and Reimplantation

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