Aim: The study aims to determine the relationship between fertility adjustment and perceived spousal support in women with infertility.Material and Methods: The correlational, descriptive type this research was conducted in eastern Turkey between December 2019 and September 2020. The study sample consisted of infertile women registered in five Family Health Centers, selected by cluster sampling method (n:139). The data were collected using the Participant Information Form prepared by researcher the Fertility Adjustment Scale (FAS), and the Spousal Support Scale. In addition to descriptive statistics, correlation and regression analyses were used in the data analysis.Results: In the study, it was found that the mean score of women in the FAS was 23.30±1.35, and the mean score in the Spousal Support Scale was 65.41±10.41. In the correlation analysis performed between fertility adjustment and spousal support in the study, a negative, weak, but significant relationship was found, and the regression analysis showed that total spousal support, financial support, and appreciation dimension explains fertility adjustment by 11%, 13%, and 10%, respectively (p<0.001). In the study, it was found that there was a statistically very weak significant relationship between emotional support, which is one of the sub-dimensions of spousal support, and fertility adjustment, and the regression analysis showed that emotional support explains fertility adjustment by 0.06% (p<0.05).Conclusion: In the study, it was found that fertility adaptation increases as spousal support increases, and the advanced analysis showed that spousal support explained fertility adjustment by 11%. It is recommended that counseling activities to be provided to couples should be enriched within this framework.