Infertility as Caused by Sperm Antibodies

Shulman, Sidney

doi:10.1159/000298902

Cited by 12 publications

(3 citation statements)

References 32 publications

(38 reference statements)

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“…The function of the strong selection of sperm that occurs within the female reproductive tract is not clear (Birkhead et al 1993), but one possible explanation is that the female tract is hostile as a defence against infection by parasites, and that sperm mortality is a by-product of this hostility (Birkhead et al 1993;Sheldon 1993). In some mammalian species, infertility may result from the female producing antibodies against a male's sperm (Shulman 1986); Schuppin et al (1985) have suggested that a similar process occurs in birds. Many of the potential causes of functional infertility in birds are likely to have negative effects on the measures of male phenotype which seem important to female birds seeking extra-pair copula tions.…”

Section: Ca U Ses Of F U N C T Io N a L F E R T Il It Ymentioning

confidence: 99%

Male phenotype, fertility, and the pursuit of extra-pair copulations by female birds

Sheldon

1994

Proc. R. Soc. Lond. B

359

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In field and laboratory studies of birds, positive associations between male phenotype and success at obtaining extra-pair copulations or extra-pair fertilizations are often interpreted as providing evidence that females are using extra-pair copulations to obtain indirect benefits for their offspring, either through genes for increased viability, or for a fisherian mating advantage. I describe a simple model, in which functional fertility (the success of ejaculates in fertilizing eggs) covaries with male phenotype, which can explain the observed associations equally well. U nder such a model, females pursue extra-pair copulations as insurance against the functional infertility of their mate, and obtain only direct benefits for themselves in their current reproductive event. Several studies of birds suggest that a relation between male phenotype and functional fertility is often likely to exist and that there are many potential causes of functional infertility. Non-manipulative field studies are unlikely to produce results which distinguish between the two hypotheses, and I discuss several alternative approaches which may allow their resolution.

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Section: Ca U Ses Of F U N C T Io N a L F E R T Il It Ymentioning

confidence: 99%

Male phenotype, fertility, and the pursuit of extra-pair copulations by female birds

Sheldon

1994

Proc. R. Soc. Lond. B

359

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“…There may be a relationship between a genital infection and the production of sperm antibodies [9][10][11][12][13][14][15][16][17][18]. Infertility due to the presence of sperm-directed antibodies is well documented [8][9][10][11][12][13][14][15][16]. Moulik et al [12] found an association between the presence of sperm antibodies and abnormally high semen viscosity.…”

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confidence: 99%

Semen Culture, Leukocytospermia, and the Presence of Sperm Antibodies in Seminal Hyperviscosity

Bregni²,

Carizza³

et al. 1999

Archives of Andrology

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Seminal hyperviscosity is generally thought to reveal genitourinary infection. The aim of the present work was to study this hypothesis. A total of 65 semen samples were obtained from males presenting for infertility screening. The samples were evaluated according to WHO criteria and microbiologically investigated, including culturing for Mycoplasma hominis and Ureaplasma urealyticum, and microscopic observation of Chlamydia trachomatis by a direct fluorescence assay. Determination of local antisperm antibodies was performed. Semen was categorized according to consistency: normal (n = 31) and high (n = 34). No difference was recorded either in the number of positive cultures, or in the number of species found in each sample. The number of white blood cells and the percentage of antibody-bound sperm showed no difference in the groups under study. There was no association between seminal hyperviscosity, positivity in semen cultures, number of species isolated in semen cultures, leukospermia, or presence of sperm antibodies. Further studies should be performed considering the evolution of the genital-infected patients to clarify the etiology of the hyperviscosity.

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“…No Brasil, calcula-se que a média de infertilidade esteja entre 8 e 10%. Segundo alguns autores, a prevalência da infertilidade ainda pode ser mais significativa, alcançando cifras em torno de 10 a 15% dos casais em idade fértil (Barad, 1991) ou até 15 a 20% (Shulman, 1986). Fonte: Farley & Belsey, 1988 O levantamento apresentado, na tabela 1, somente investigou infertilidade primária, uma vez que estimativas da prevalência de infertilidade secundária devem incluir a investigação da exposição da mulher ao risco de engravidar (se está usando algum método contraceptivo ou se está amamentando) e portanto, difíceis de serem realizadas (Farley & Belsey, 1988).…”

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Estudo Comparativo entre os Métodos de Sonohisterossalpingografia Contrastada, Histerossalpingografia e Laparoscopia

Ferreira¹

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Infertility as Caused by Sperm Antibodies

Cited by 12 publications

References 32 publications

Male phenotype, fertility, and the pursuit of extra-pair copulations by female birds

Male phenotype, fertility, and the pursuit of extra-pair copulations by female birds

Semen Culture, Leukocytospermia, and the Presence of Sperm Antibodies in Seminal Hyperviscosity

Estudo Comparativo entre os Métodos de Sonohisterossalpingografia Contrastada, Histerossalpingografia e Laparoscopia

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