Infiltration of peripheral immune cells into the olfactory bulb in a mouse model of acute nasal inflammation

Asano, Hinami; Hasegawa-Ishii, Sanae; Arae, Ken; Obara, Aki; Laumet, Geoffroy; Dantzer, Robert; Shimada, Atsuyoshi

doi:10.1016/j.jneuroim.2022.577897

Cited by 6 publications

(9 citation statements)

References 41 publications

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“…A single i.n. administration of LPS also upregulates expression of pro-inflammatory cytokines TNF-α, IL-1β, and IL-6, as well as anti-inflammatory cytokines IL-10 and TGFβ in the OB [48]. Furthermore, chemokines responsible for recruiting monocytes and neutrophils such as CCL2 and CXCL1, respectively, are observed in the superficial OB layers after this single LPS administration [48].…”

Section: Olfactory Bulb Immune and Inflammatory Responsementioning

confidence: 86%

“…Interestingly, OECs in the ONL were found to express CCL2, the primary ligand which initiates the activation of C-C chemokine receptor 2 (CCR2) in immune responses, just 12 h following a single i.n. administration of LPS [48,66]. CCR2-positive immune cells are also distributed throughout the ONL and are closely localized to the CCL2-positive OECs, suggesting that OECs in the OB may be the primary cell type responsible for recruiting immune cells during a state of inflammation.…”

Section: Olfactory Bulb Immune and Inflammatory Responsementioning

confidence: 99%

“…Rather than utilizing chemicals to induce inflammation of the OE, there are studies that utilize derivatives of microbial pathogens such as Satratoxin G [15,17], roridin A [13,16], polyinosinic:polycytidylic acid [Poly(I:C)] [20,44], and lipopolysaccharide (LPS) [21,25,[45][46][47][48] to better elucidate the etiological factors of immune responses in sinonasal diseases. Some sinonasal diseases including rhinitis, sinusitis, and rhinosinusitis can be primarily attributed to viral and/or bacterial infections [49].…”

Section: Alterations To Olfactory Bulb Anatomy In Animal Models Of Na...mentioning

confidence: 99%

“…The impact of i.n. administration of LPS on the mouse olfactory system has been more extensively investigated [21,[45][46][47][48]. LPS is an endotoxin found on the cell surface of Gramnegative bacteria and interacts with the pattern recognition receptor, toll-like receptor 4 (TLR4), of various host cells.…”

Section: Alterations To Olfactory Bulb Anatomy In Animal Models Of Na...mentioning

confidence: 99%

“…It has been shown that a single i.n. administration of LPS results in the accumulation of inflammatory monocytes, microglia, astrocytes, neutrophils, and even T cells along the ONL at 12 and 24 h after the administration [21,48]. Microglia and astrocytes are also observed in the superficial OB layers (ONL, GL, and EPL) following i.n.…”

Section: Olfactory Bulb Immune and Inflammatory Responsementioning

confidence: 99%

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Effects of nasal inflammation on the olfactory bulb

LaFever

Imamura

2022

J Neuroinflammation

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Sinonasal diseases, such as rhinosinusitis, affect up to 12% of individuals each year which constitutes these diseases as some of the most common medical conditions in the world. Exposure to environmental pathogens and toxicants via the nasal cavity can result in a severe inflammatory state commonly observed in these conditions. It is well understood that the epithelial and neuronal cells lining the olfactory mucosa, including olfactory sensory neurons (OSNs), are significantly damaged in these diseases. Prolonged inflammation of the nasal cavity may also lead to hyposmia or anosmia. Although various environmental agents induce inflammation in different ways via distinct cellular and molecular interactions, nasal inflammation has similar consequences on the structure and homeostatic function of the olfactory bulb (OB) which is the first relay center for olfactory information in the brain. Atrophy of the OB occurs via thinning of the superficial OB layers including the olfactory nerve layer, glomerular layer, and superficial external plexiform layer. Intrabulbar circuits of the OB which include connectivity between OB projection neurons, OSNs, and interneurons become significantly dysregulated in which synaptic pruning and dendritic retraction take place. Furthermore, glial cells and other immune cells become hyperactivated and induce a state of inflammation in the OB which results in upregulated cytokine production. Moreover, many of these features of nasal inflammation are present in the case of SARS-CoV-2 infection. This review summarizes the impact of nasal inflammation on the morphological and physiological features of the rodent OB.

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Section: Olfactory Bulb Immune and Inflammatory Responsementioning

confidence: 86%

Section: Olfactory Bulb Immune and Inflammatory Responsementioning

confidence: 99%