Inflammasomes and type 2 diabetes: An updated systematic review

Sepehri, Zahra; Kiani, Zohre; Afshari, Mahdi; Kohan, Farhad; Dalvand, Azadeh; Ghavami, Saeid

doi:10.1016/j.imlet.2017.10.010

Cited by 76 publications

(58 citation statements)

References 90 publications

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Section: Discussionmentioning

confidence: 99%

“…As the important intracellular receptors, NLRs are supposed to participate in the induction of chronic inflammation in diabetes or its complications . The association between NLRP3 inflammasome and type 2 diabetes has been proved . The latest studies have shown that aberrant activation of NLRP3‐inflammasomes was closely related to the development and prognosis of diabetes and its complications .…”

Section: Discussionmentioning

confidence: 99%

“…NOD‐like receptors (NLRs) are main family of pattern recognition receptor (PRRs), which participate in recognizing pathogenic or endogenous stimuli, mediating inflammatory response and coordinating the elimination of pathogens or endogenous stimuli . It has been reported that NLRP3‐inflammasome participated in not only the formation of the chronic inflammation but also the induction of several diabetic complications in diabetic patients . In further research, AGEs could impair NLRP3 inflammasome‐mediated innate immune response in macrophages .…”

Section: Introductionmentioning

confidence: 99%

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The effect of NLRP inflammasome on the regulation of AGEs‐induced inflammatory response in human periodontal ligament cells

Zhang

et al. 2019

J of Periodontal Research

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Background and Objective Diabetes influences the frequency and development of periodontitis. Inflammation of human periodontal ligament cells (HPDLCs) participates in this pathologic process. Hence, this study aims to explore whether advanced glycation end products (AGEs), by‐products of diabetes, could exaggerate inflammation induced by muramyl dipeptide (MDP) in HPDLCs, and whether nucleotide‐binding oligomerization domain‐like receptors (NLRs) signaling pathway was involved. Material and Methods Human periodontal ligament cells were pre‐treated with 100 μg/mL AGEs for 24 hours and stimulated with 10 μg/mL MDP for 24 hours. IL‐6, IL‐1β, and RAGE were detected, and the activation of NF‐κB signaling pathway was observed. The expression of NLRs was evaluated with or without silencing RAGE or blocking NF‐κB pathway under AGEs stimulation. Statistical analyses were performed by using independent sample t test. Results Advanced glycation end products induced significant increase of inflammatory cytokines in HPDLCs (P < 0.05). Results of western blot (WB) showed that after 45 minutes stimulation of AGEs, p‐p65/p65 ratio peaked; AGEs promoted the expression of NLRP1, NLRP3, and apoptosis‐associated speck‐like protein containing a CARD (ASC). After silencing RAGE or blocking NF‐κB pathway, the up‐regulation of NLRs protein caused by AGEs was attenuated. Additionally, AGEs pre‐treatment could enhance the inflammatory response of MDP and the expression of NLRs, which were demonstrated by more expression of IL‐6, IL‐1β, NOD2, NLRP1, NLRP3, and ASC. Conclusion Advanced glycation end products induced inflammatory response in HPDLCs via NLRP1‐inflammasome and NLRP3‐inflammasome activation in which NF‐κB signal pathway was involved. Besides, AGEs promoted the inflammatory response of MDP via NOD2, NLRP1‐inflammasome, and NLRP3‐inflammasome.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The effect of NLRP inflammasome on the regulation of AGEs‐induced inflammatory response in human periodontal ligament cells

Zhang

et al. 2019

J of Periodontal Research

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“…There was no limitation based on the date of study publications. The following index terms were used: "vitamin D" OR "vitamin D 2 " OR "vitamin D 3 " OR "cholecalciferol" OR "ergocalciferol" OR "calcitriol" OR "alfacalcidol" OR "paricalcitol" OR "doxercalciferol" OR "vitamin D analogues" OR "25-hydroxyvitamin D 2 " OR "25-hydroxyvitamin D 3 (25[OH]D 3 )" OR "hydroxycholecalciferol" OR "dihydrotachysterol" AND "type 2 diabetes" OR "prediabetes" AND "supplementation" AND "adipokine" OR "cytokine" OR "inflammation" OR "high-sensitivity C-reactive protein" OR "tumor necrosis factor" OR "interleukin". Reference lists and related records were manually reviewed.…”

Section: Literature Searchmentioning

confidence: 99%

“…According to the World Health Organization, there were approximately 415 million people with diabetes in the world, which could rise to 642 million by 2040 [1]. Type 2 diabetes mellitus (T2DM) is a chronic, progressive metabolic disease characterized by persistent hyperglycemia that is accompanied by chronic inflammation [2]. A growing body of evidence has suggested that high concentrations of circulating inflammatory biomarkers, such as interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α) and high-sensitivity C-reactive protein (hs-CRP), might play a critical role in the development of T2DM [3][4][5].…”

Section: Introductionmentioning

confidence: 99%

Effect of Vitamin D Supplementation on Some Inflammatory Biomarkers in Type 2 Diabetes Mellitus Subjects: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Tian

Xiao

et al. 2018

Ann Nutr Metab

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Background/Aims: The mechanism, by which vitamin D influences inflammatory biomarkers in type 2 diabetes mellitus (T2DM), is not very well known. Thus, a meta-analysis of randomized controlled trials was conducted to assess the effect of vitamin D supplementation on some inflammatory biomarkers in T2DM subjects. Methods: We searched randomized controlled trials from PubMed and the Cochrane Library in October 2017 and conducted a meta-analysis to evaluate the effectiveness of vitamin D supplementation on high-sensitivity C-reactive protein (hs-CRP), tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6). Either a fixed-effects or a random-effects model was used to calculate pooled effects. Results: We identified 13 studies that met our inclusion criteria. The results indicated that the vitamin D supplementation significant decreased the hs-CRP level by 0.45 μg/mL, whereas the vitamin D supplementation did not influence the TNF-α and IL-6. Subgroup analysis showed that vitamin D significantly lowered hs-CRP by 0.34 μg/mL among trials with a daily vitamin D dose ≤4,000 IU and by 0.31 μg/mL among trials with time of vitamin D supplementation > 12 weeks. Conclusions: Vitamin D supplementation is beneficial for the reduction of hs-CRP inT2DM subjects but does not have a significant influence on TNF-α and IL-6 in T2DM subjects.

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Interactions between NLRP3 inflammasome and glycolysis in macrophages: New insights into chronic inflammation pathogenesis

Guo

Zeng

et al. 2021

Immunity Inflam & Disease

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NLRP3 inflammasome activation in macrophages fuels sterile inflammation, which has been tied with metabolic reprogramming characterized by high glycolysis and low oxidative phosphorylation. The key enzymes in glycolysis and glycolysis-related products can regulate and activate NLRP3 inflammasome. In turn, NLRP3 inflammasome is considered to affect glycolysis, as well.However, the exact mechanism remains ambiguous. On the basis of these findings, the focus of this review is mainly on the developments in our understanding of interaction between NLRP3 inflammasome activation and glycolysis in macrophages, and small molecule compounds that influence the activation of NLRP3 inflammasomes by regulating glycolysis in macrophages.The application of this interaction in the treatment of diseases is also discussed. This paper may yield valuable clues for development of novel therapeutic agent for NLRP3 inflammasome-related diseases.

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Inflammasomes and type 2 diabetes: An updated systematic review

Cited by 76 publications

References 90 publications

The effect of NLRP inflammasome on the regulation of AGEs‐induced inflammatory response in human periodontal ligament cells

The effect of NLRP inflammasome on the regulation of AGEs‐induced inflammatory response in human periodontal ligament cells

Effect of Vitamin D Supplementation on Some Inflammatory Biomarkers in Type 2 Diabetes Mellitus Subjects: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Interactions between NLRP3 inflammasome and glycolysis in macrophages: New insights into chronic inflammation pathogenesis

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