Inflammation, atrophy, and prostate carcinogenesis

Marzo, Angelo M. De; Nakai, Yasutomo; Nelson, William G.

doi:10.1016/j.urolonc.2007.05.007

Cited by 95 publications

(97 citation statements)

References 33 publications

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“…Considerable data support the hypothesis that dietary/ lifestyle factors affect prostate cancer incidence by promoting chronic inflammation and/or oxidative stress, ultimately leading to DNA damage, epigenetic modifications, or other perturbations associated with cancer initiation (De Marzo et al 2007a;. This model has consequently emphasized the role of antioxidants and anti-inflamatory agents in protection against prostate cancer (DeWeese et al 2001).…”

Section: Dietary and Lifestyle Factors In Cancer Preventionmentioning

confidence: 99%

Molecular genetics of prostate cancer: new prospects for old challenges

Shen¹,

2010

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Despite much recent progress, prostate cancer continues to represent a major cause of cancer-related mortality and morbidity in men. Since early studies on the role of the androgen receptor that led to the advent of androgen deprivation therapy in the 1940s, there has long been intensive interest in the basic mechanisms underlying prostate cancer initiation and progression, as well as the potential to target these processes for therapeutic intervention. Here, we present an overview of major themes in prostate cancer research, focusing on current knowledge of principal events in cancer initiation and progression. We discuss recent advances, including new insights into the mechanisms of castration resistance, identification of stem cells and tumor-initiating cells, and development of mouse models for preclinical evaluation of novel therapuetics. Overall, we highlight the tremendous research progress made in recent years, and underscore the challenges that lie ahead.

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Section: Dietary and Lifestyle Factors In Cancer Preventionmentioning

confidence: 99%

Molecular genetics of prostate cancer: new prospects for old challenges

Shen¹,

2010

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“…The etiologic agents that contribute to the development of human prostatic diseases such as benign prostate hyperplasia (BPH) and prostate cancer remain largely unknown (1)(2)(3)(4). Studies have suggested close links among certain infections of the prostate, chronic inflammation, and the development of inflammation-associated prostatic diseases (5)(6)(7)(8)(9)(10).…”

Section: Introductionmentioning

confidence: 99%

“…Studies have suggested close links among certain infections of the prostate, chronic inflammation, and the development of inflammation-associated prostatic diseases (5)(6)(7)(8)(9)(10). It has been proposed that certain infections of the prostate contribute to the development of chronic inflammation and regenerative "risk factor" lesions, referred to as proliferative inflammatory atrophy, contribute to the development of prostate cancer (3)(4)(5). Accordingly, studies have found an increased relative risk of prostate cancer in men with a prior history of certain sexually transmitted infections or prostatitis, which are often associated with intraprostatic inflammation (6,7).…”

Section: Introductionmentioning

confidence: 99%

AIM2, an IFN-Inducible Cytosolic DNA Sensor, in the Development of Benign Prostate Hyperplasia and Prostate Cancer

Ponomareva

Liu

Duan

et al. 2013

Molecular Cancer Research

106

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Close links have been noted between chronic inflammation of the prostate and the development of human prostatic diseases such as benign prostate hyperplasia (BPH) and prostate cancer. However, the molecular mechanisms that contribute to prostatic inflammation remain largely unexplored. Recent studies have indicated that the IFN-inducible AIM2 protein is a cytosolic DNA sensor in macrophages and keratinocytes. Upon sensing DNA, AIM2 recruits the adaptor ASC and pro-CASP1 to assemble the AIM2 inflammasome. Activation of the AIM2 inflammasome cleaves pro-interleukin (IL)-1b and pro-IL-18 and promotes the secretion of IL-1b and IL-18 proinflammatory cytokines. Given that human prostatic infections are associated with chronic inflammation, the development of BPH is associated with an accumulation of senescent cells with a proinflammatory phenotype, and the development of prostate cancer is associated with the loss of IFN signaling, the role of AIM2 in mediating the formation of prostatic diseases was investigated. It was determined that IFNs (a, b, or g) induced AIM2 expression in human prostate epithelial cells and cytosolic DNA activated the AIM2 inflammasome. Steady-state levels of the AIM2 mRNA were higher in BPH than in normal prostate tissue. However, the levels of AIM2 mRNA were significantly lower in clinical tumor specimens. Accordingly, constitutive levels of AIM2 mRNA and protein were lower in a subset of prostate cancer cells as compared with BPH cells. Further, the cytosolic DNA activated the AIM2 inflammasome in the androgen receptor-negative PC3 prostate cancer cell line, suggesting that AIM2-mediated events are independent of androgen receptor status.

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“…Affonso Celso Piovesan ve ark tarafından yapılan bir çalışmada histolojik prostatit tanısı konulmuş 143 hasta ile BPH tanısı konulmuş 38 hasta grupları kendi aralarında serum PSA dansitesi açısından karşılaştırıldığında istatistiksel olarak anlamlı bir fark saptanmadığı bildirilmiştir (9). Prostatik inflamasyonun potansiyel nedenlerinden bazıları direk infeksiyon, idrar reflüsü, beslenme faktörleri, östrojen veya bunların kombinasyonlarıdır (10). Belirtilen bu ve benzeri nedenlerin prostatta serbest radikallerin meydana gelmesine ve bunun sonucu olarak ta oksidatif hasarın ortaya çıkmasına neden olduğu dolayısıyla prostat dokusunda hasara neden olduğu bildirilmiştir(10).…”

Section: Discussionunclassified

“…(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)) ve şiddetli (20-35) olmak üzere skorlandı. Çalışmamıza nörolo-jik hastalığı olanlar, üretra darlığı olanlar, kronik karaciğer, böbrek yetmezliği ve diabetes mellitus gibi kronik sistemik bir hastalığı olan olgular, geçirilmiş pelvik cerrahi öyküsü olanlar, daha önceden psikiyatrik bozukluk tanısı ile antidepresan, antipsikotik ve anksiyolitik ilaç alan olgular ile antikonvülzan gibi kronik ilaç tedavisi alan olgular ve yakın zamanda geçirilmiş üriner trakt infeksiyonu olan olgular dahil edilmedi.…”

Section: Introductionunclassified

Alt üriner sistem semptomları ile serum PSA seviyeleri ve histolojik prostatit arasındaki ilişki.

Fırat¹

2016

J Contemp Med

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Amaç: Bu çalışmanın amacı histolojik olarak tespit edilen prostatik inflamasyonun serum PSA seviyeleri ve alt üriner sistem semptomları üzerine olan etkilerini araştırmaktı. Gereç yöntem: Ocak 2005 ve Ocak 2012 tarihleri arasında transrektal ultrasonografi eşliğinde prostat biyopsisi yapılan toplam 546 hasta retrospektif olarak incelendi. Hastalar, histolojik olarak prostatik inflamasyon tespit edilenler (Grup 1: 333) ve sadece benign prostatik hiperplazi tespit edilenler (Grup 2: 213) olmak üzere kendi içerisinde 2 gruba ayrıldılar. Gruplar, serum PSA seviyeleri ve alt üriner sistem semptomları açısından aralarında karşılaştırıldılar. Alt üriner sistem semptomlarını değerlendirmek için Uluslararası Prostat Semptom Skoru (IPSS) kullanıldı. Semptomlar hafif ( 0-7), orta (8-19) ve şiddetli (20-35) olmak üzere skorlandı. Bulgular: Hastaların yaş ortalamaları grup 1 ve grup 2 için sırasıyla 64.86±7.86 ve 63.69±7.89 yıl idi (p>0.05). Ortalama PSA değerleri grup 1'de 10.32±8.39 iken grup 2'de 9.63±9.69 olarak tespit edildi (p=0.016). IPSS skorları grup 1 ve 2 için sırasıyla 15.52±5.76 ve 13.46±6.04 olarak saptandı (p<0.001).Sonuç: Bu bulgulara göre kronik prostatik inflamasyonun (Tip 4), alt üriner sistem semptomları ile ilişkili olabileceğini söyleyebiliriz. Ayrıca prostat biyopsilerinde saptanan histolojik prostatik inflamasyonun serum PSA seviyeleri üzerine etki ettiği anlaşılmaktadır.

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Inflammation, atrophy, and prostate carcinogenesis

Cited by 95 publications

References 33 publications

Molecular genetics of prostate cancer: new prospects for old challenges

Molecular genetics of prostate cancer: new prospects for old challenges

AIM2, an IFN-Inducible Cytosolic DNA Sensor, in the Development of Benign Prostate Hyperplasia and Prostate Cancer

Alt üriner sistem semptomları ile serum PSA seviyeleri ve histolojik prostatit arasındaki ilişki.

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