Inflammation, Immunity, and Vaccines for <i><scp>H</scp>elicobact</i>er <i>pylori</i> Infection

Ihan, Alojz; Pinchuk, Irina V.; Beswick, Ellen J.

doi:10.1111/j.1523-5378.2012.00977.x

Cited by 23 publications

(15 citation statements)

References 46 publications

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“…The failure of immune system to eradicate H. pylori during the acute phase of infection may result in an inadequate immune response leading to chronic gastritis, development of peptic ulcer disease, or even gastric cancer [ 20 ]. We have proven in our previous study that the success of H. pylori eradication therapy by antibiotics is at least partially dependent upon cytokine response by T cells [ 19 ].…”

Section: Discussionmentioning

confidence: 99%

Differences in the Antigens ofHelicobacter pyloriStrains Influence on the Innate Immune Response in theIn VitroExperiments

Skvarč

Kopitar

Kos

et al. 2014

Mediators of Inflammation

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The immune response to Helicobacter pylori importantly determines the pathogenesis of infection as well as the success of antibiotic eradication of the bacteria. Strains of H. pylori were gathered from 14 patients who failed to eradicate H. pylori infection with antibiotics—therapy resistant strains (TRS)—or from patients who were able to eradicate H. pylori infection—therapy susceptible strains (TSS). The THP-1 cells were stimulated with H. pylori antigens. Cathepsin X expression on THP-1 cells and concentration of cytokines in the supernatant of THP-1 cells were measured with a flow cytometer. TSS H. pylori antigens increased the proportion of cathepsin X positive cells compared to TRS H. pylori antigens. TSS H. pylori antigens induced higher secretion of IL-12 and IL-6 compared to TRS H. pylori antigens (P < 0.001; 0.02). Polymyxin B, a lipid A inhibitor, lowered the secretion of IL-12 and IL-6 in TRS and TSS. We demonstrated a H. pylori strain-dependent cathepsin X and cytokine expression that can be associated with H. pylori resistance to eradication due to lack of effective immune response. Differences in lipid A of H. pylori might have an influence on the insufficient immune response, especially on phagocytosis.

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Section: Discussionmentioning

confidence: 99%

Differences in the Antigens ofHelicobacter pyloriStrains Influence on the Innate Immune Response in theIn VitroExperiments

Skvarč

Kopitar

Kos

et al. 2014

Mediators of Inflammation

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“…The immunomodulatory effect of fucoidans is commonly known . The negative influences exerted by H. pylori on inborn and acquired immunity have been discussed above . Polysaccharides from marine algae, while possessing a broad spectrum of biological activities, are also antagonists of functions of both inborn and acquired immunity; this finding enables researchers to recommend them as correctors of disturbances caused by humoral and cellular factors of the organisms defense against the H. pylori infection.…”

Section: Immunomodulatory Effects Of Fucoidans and Prospects For The mentioning

confidence: 99%

Review: Prospects for the Use of Extracts and Polysaccharides from Marine Algae to Prevent and Treat the Diseases Caused by Helicobacter pylori

Беседнова¹,

Ts²,

Сомова³

et al. 2015

Helicobacter

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Helicobacter pylori possesses a broad spectrum of pathogenic factors that allow it to survive and colonize the gastric mucosa, and thus, the pathogenetic targets, which have the same diversity, require search for and the development of alternative, effective, and innocuous means for the eradication of H. pylori. In recent years, fucoidans have been extensively studied due to the numerous interesting biological activities, including the anti-adhesive, anti-oxidative, antitoxic, immunomodulatory, anticoagulant, and anti-infection effects. This review summarizes the data on the effects of extracts and sulfated polysaccharides of marine algae, mainly fucoidans, on pathogenic targets in Helicobacter infection. The pathogenetic targets for therapeutic agents after H. pylori infection, such as flagellas, urease, and other enzymes, including adhesins, cytotoxin A (VacA), phospholipase, and L-8, are characterized here. The main target for the sulfated polysaccharides of seaweed is cell receptors of the gastric mucosa. This review presents the published data about the pleiotropic anti-inflammatory effects of polysaccharides on the gastric mucosa. It is known that fucoidan and other sulfated polysaccharides from algae have anti-ulcer effects, prevent the adhesion of H. pylori to, and reduce the formation of biofilm. The authors speculate that the effect of sulfated polysaccharides on the infectious process caused by H. pylori is related to their action on innate and adaptive immunity cells, and also anti-oxidant and antitoxic potential. Presented in the review are materials indicated for the study of extracts and sulfated polysaccharides from seaweed during H. pylori infection, as these compounds are characterized by multimodality actions. Based on the analysis of literary materials in recent years, the authors concluded that fucoidan can be attributed to the generation of new candidates to create drugs intended for the inclusion in the scheme of eradication therapy of H. pylori infection.

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“…Ammonia that produced from the activity of HP urease on urea, react with hypochlorous anion reacts to produce monochloramine (NH 2 Cl), the lipophilic cytotoxic oxidant which freely penetrates gastric epithelial cells membranes to oxidize intracellular components and produce DNA damage. On the other hand, CagA was shown to induce spermine oxidase in gastric epithelial cells and produce H 2 O 2 that leads to apoptosis, and DNA damage during infection [42]. Moderate to heavy lymphocytic infiltration detected in the present study supports the suggestion that HP is capable of invading gastric mucosal epithelial cells [43] and gastric epithelia continuously exposes to oxidative stress due to HP CagA, urease and other products causing induction of NF-κB that enhance inflammatory reaction by a network of cytokines and chemokines for attraction of different immunocytes to gastric epithelia and induce their activation [44].…”

Section: Al-ezzymentioning

confidence: 99%

Immunohistopathological Role of Bcl2 and P53 Gene Expression in Helicobacter Pylori Cytotoxin-Associated Gene a Positive Versus Cytotoxin-Associated Gene a Negative Antral Predominant Non-Atrophic Gastritis in Iraqi Patients

Al-Ezzy

2017

Asian J Pharm Clin Res

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Inflammation, Immunity, and Vaccines for Helicobacter pylori Infection

Cited by 23 publications

References 46 publications

Differences in the Antigens ofHelicobacter pyloriStrains Influence on the Innate Immune Response in theIn VitroExperiments

Differences in the Antigens ofHelicobacter pyloriStrains Influence on the Innate Immune Response in theIn VitroExperiments

Review: Prospects for the Use of Extracts and Polysaccharides from Marine Algae to Prevent and Treat the Diseases Caused by Helicobacter pylori

Immunohistopathological Role of Bcl2 and P53 Gene Expression in Helicobacter Pylori Cytotoxin-Associated Gene a Positive Versus Cytotoxin-Associated Gene a Negative Antral Predominant Non-Atrophic Gastritis in Iraqi Patients

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