Inflammation is associated with a worsening of presbycusis: Evidence from the MRC national study of hearing

Verschuur, Carl; Agyemang-Prempeh, Akosua; Newman, Tracey A.

doi:10.3109/14992027.2014.891057

Cited by 79 publications

(64 citation statements)

References 34 publications

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“…Vershcuur and colleagues concluded that inflammation is a component of the mechanisms underlying presbycusis . In order to eliminate potential sample bias, this same group conducted a similar investigation on a different population data set and concluded many of the same basic findings (Verschuur et al, 2014). …”

Section: Chronic Inflammation In Age-related Hearing Lossmentioning

confidence: 96%

“…The pathway of chronic inflammation is not fully understood, however several possible mechanisms have been proposed (Franceschi, Campisi, 2014). Due to the buildup of pro-inflammatory proteins, inflammaging is likely to be a result of an acquired high “inflammatory state” (Verschuur et al, 2014). Since the overall goal of an inflammatory reaction is to clear the body of a particular cause of cell injury, optimal rates are beneficial.…”

Section: Chronic Inflammation or Inflammagingmentioning

confidence: 99%

“…This age-dependent immunosenescence process ultimately results in the body becoming increasingly worse at controlling or down-regulating the production of pro-inflammatory proteins during and after immune responses (Capri et al, 2006). Consequently, a progressively higher inflammatory state is observed in many aging tissues (Verschuur et al, 2014; Fulop et al, 2016). However, the potential pathways of inflammation and its effect on ARHL have received little attention in the fields of hearing research and auditory neuroscience.…”

Section: Introductionmentioning

confidence: 99%

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Chronic inflammation – inflammaging – in the ageing cochlea: A novel target for future presbycusis therapy

Watson

Ding

Liu

et al. 2017

Ageing Research Reviews

149

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Chronic, low-grade inflammation, or inflammaging, is a crucial contributor to various age-related pathologies and natural processes in aging tissue, including the nervous system. Over the past two decades, much effort has been done to understand the mechanisms of inflammaging in disease models such as type II diabetes, cardiovascular disease, Alzheimer’s disease, Parkinson’s disease, and others. However, despite being the most prevalent neurodegenerative disorder, the number one communication disorder, and one of the top three chronic medical conditions of our aged population; little research has been conducted on the potential role of inflammation in age-related hearing loss (ARHL). Recently, it has been suggested that there is an inflammatory presence in the cochlea, perhaps involving diffusion processes of the blood-brain barrier as it relates to the inner ear. Recent research has found correlations between hearing loss and markers such as C-reactive protein, IL-6, and TNF-α indicating inflammatory status in human case-cohort studies. However, there have been very few reports of in vivo research investigating the role of chronic inflammation’s in hearing loss in the aging cochlea. Future research directed at better understanding the mechanisms of inflammation in the cochlea as well as the natural changes acquired with aging may provide a better understanding of how this process can accelerate presbycusis. Animal model experimentation and pre-clinical studies designed to recognize and characterize cochlear inflammatory mechanisms may suggest novel treatment strategies for preventing or treating ARHL. In this review, we seek to summarize key research in chronic inflammation, discuss its implications for possible roles in ARHL, and finally suggest directions for future investigations.

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Section: Chronic Inflammation In Age-related Hearing Lossmentioning

confidence: 96%

Section: Chronic Inflammation or Inflammagingmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Chronic inflammation – inflammaging – in the ageing cochlea: A novel target for future presbycusis therapy

Watson

Ding

Liu

et al. 2017

Ageing Research Reviews

149

View full text Add to dashboard Cite

show abstract

“…However, average swimming time was shorter for the mice administered 150 mg/kg KRG than for the other groups (*p b 0.05). associated chronic increase in inflammatory status and presbycusis may provide new avenues to reduce the progression of this condition (Verschuur et al, 2014). Studies have shown that autophagy is a critical regulator of organellar homeostasis, particularly in mitochondria (Koga and Cuervo, 2011).…”

Section: Discussionmentioning

confidence: 99%

“…Combination antioxidant therapy has been reported to prevent AHL in C57BL/6 mice (Heman-Ackah et al, 2010). However, a report about antioxidant-enriched diet does not delay age-related auditory pathology in female CBA/J mice (Sha et al, 2012) raises the issue that the complex biological mechanism underlying AHL is still poorly understood (Verschuur et al, 2014). Identification of a link between the age- In the tail-hanging test, the balance responses were scored as described in Materials and methods section.…”

Section: Discussionmentioning

confidence: 99%

Red ginseng delays age-related hearing and vestibular dysfunction in C57BL/6 mice

Tian

Kim

Lim

et al. 2014

Experimental Gerontology

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The potential role of the SIRT1‐Nrf2 signaling pathway in alleviating hidden hearing loss via antioxidant stress

Zheng,

Zhang,

et al. 2024

Cell Biology International

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Hidden hearing loss (HHL) is characterized by normal audiometric thresholds but impaired auditory function, particularly in noisy environments. In vivo, we employed auditory brainstem response (ABR) testing and ribbon synapses counting to assess changes in mouse hearing function, and observed the morphology of hair cells through scanning electron microscopy. SRT1720 was administered to the cochlea via round window injection. In vitro, western blot analysis and RT‐qPCR were used, and Lenti‐shNrf2 was used to knockdown Nrf2 expression. In addition, various oxidative stress indicators were detected by immunofluorescence, kit‐based assays, and flow cytometry. ABR measurement of HHL mouse showed a significant increase in hearing threshold, as well as a decrease and delay in the I wave amplitude and latency on the first day after noise exposure. Histological observation showed a significant loss of ribbon synapses and stereocilia lodging. HHL mice exhibited oxidative stress, which was reduced by pretreatment with SRT1720. Additionally, SRT1720 could reduce hydrogen peroxide‐induced oxidative stress in HEI‐OC1 cells through activating the SIRT1/Nrf2 pathway. Subsequent experiments with Nrf2 knockdown confirmed the importance of this pathway. findings highlight oxidative stress as the primary contributor to HHL, with the SIRT1/Nrf2 signaling pathway emerging as a promising therapeutic target for alleviating HHL.

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Inflammation is associated with a worsening of presbycusis: Evidence from the MRC national study of hearing

Abstract: The current findings support an association between inflammaging (a condition potentially amenable to pharmacological treatment or lifestyle management) and presbycusis.

Cited by 79 publications

References 34 publications

Chronic inflammation – inflammaging – in the ageing cochlea: A novel target for future presbycusis therapy

Chronic inflammation – inflammaging – in the ageing cochlea: A novel target for future presbycusis therapy

Red ginseng delays age-related hearing and vestibular dysfunction in C57BL/6 mice

The potential role of the SIRT1‐Nrf2 signaling pathway in alleviating hidden hearing loss via antioxidant stress

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