Inflammation is preceded by tumor necrosis factor‐dependent infiltration of mesenchymal cells in experimental arthritis

Marinova‐Mutafchieva, Lilia; Williams, Richard O.; Funa, Keiko; Maini, R. N.; Zvaifler, Nathan J.

doi:10.1002/art.10126

Cited by 130 publications

(112 citation statements)

References 20 publications

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“…Evidence for such an infiltrate has been described in animal models of RA, in which TNF-responsive mesenchymal cells were identified within enlarged bony canals connecting bone marrow to synovium (29). Unfortunately, there are no MRI studies of animal models of early RA, and such studies are urgently needed.…”

Section: Discussionmentioning

confidence: 99%

Bone edema scored on magnetic resonance imaging scans of the dominant carpus at presentation predicts radiographic joint damage of the hands and feet six years later in patients with rheumatoid arthritis

McQueen¹,

Benton²,

Perry³

et al. 2003

Arthritis & Rheumatism

387

226

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Objective. Magnetic resonance imaging (MRI) is capable of revealing synovitis and tendinitis in early rheumatoid arthritis (RA), as well as bone edema and erosion. These features are visible before radiographic joint damage occurs. We sought to examine whether MRI of one body region (the wrist) can be used to predict whole-body radiography scores reflecting joint damage at 6 years.Methods. We conducted a 6-year prospective study of a cohort of patients who fulfilled the criteria for RA at presentation, using clinical parameters, radiographs, and MRI scans of the dominant wrist. Of the 42 patients enrolled at baseline, full MRI, radiographic, and clinical data were available for 31 at 6-year followup. MRI scans were scored by 2 radiologists, using a validated scoring system. Radiographs of the hands and feet were graded using the modified Sharp scoring method. MRI and radiography scores obtained at baseline and 6 years were compared, and baseline MRI scores were examined for their ability to predict radiographic outcome at 6 years.Results. At 6 years, the total Sharp score correlated significantly with the total MRI score and the MRI erosion score (r ‫؍‬ 0.81, P < 0.0001 and r ‫؍‬ 0.79, P < 0.0001, respectively). The 6-year Sharp score also correlated with the baseline total MRI and MRI erosion scores (r ‫؍‬ 0.56, P < 0.0001 and r ‫؍‬ 0.33, P ‫؍‬ 0.03, respectively). MRI synovitis and bone edema scores remained constant for the group as a whole over 6 years, but bone erosion scores progressed (P ‫؍‬ 0.0001), consistent with radiographic deterioration. Erosions on 6-year MRI scans were frequently preceded by MRI bone edema at baseline (odds ratio 6.5, 95% confidence interval 2.78-18.1). Regression models indicated that the baseline MRI bone edema score was predictive of the 6-year total Sharp score (P ‫؍‬ 0.01), as was the C-reactive protein (CRP) level (P ‫؍‬ 0.0002). Neither shared epitope status nor swollen or tender joint counts predicted radiographic outcome in this cohort. A model incorporating baseline MRI scores for erosion, bone edema, synovitis, and tendinitis plus the CRP level and the erythrocyte sedimentation rate explained 59% of the variance in the 6-year total Sharp score (R 2 ‫؍‬ 0.59, adjusted R 2 ‫؍‬ 0.44). Conclusion. MRI scans performed at the first presentation of RA can be used to help predict future radiographic damage, allowing disease-modifying therapy to be targeted to patients with aggressive disease.

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Section: Discussionmentioning

confidence: 99%

Bone edema scored on magnetic resonance imaging scans of the dominant carpus at presentation predicts radiographic joint damage of the hands and feet six years later in patients with rheumatoid arthritis

McQueen¹,

Benton²,

Perry³

et al. 2003

Arthritis & Rheumatism

387

226

View full text Add to dashboard Cite

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“…Similarly, tumor necrosis factor ␣ and stem cell-derived growth factor 1 may play somewhat similar roles in supporting the erosive synovitis of RA (42,43).…”

Section: Mechanisms Of Autoimmunity and Rituximabmentioning

confidence: 98%

Rituximab therapy and autoimmune disorders: Prospects for anti–B cell therapy

Silverman¹,

Weisman²

2003

Arthritis & Rheumatism

344

204

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“…33,34 In experimental CIA, MSCs were found in the joints of animals at 2 weeks before the onset of the disease. At that time, synovial hyperplasia was associated to an increase of medullar cells in the epiphyseal region and formation of canals between the bone marrow and the joint cavity.…”

Section: Hematopoietic and Mscs In Autoimmune Diseasesmentioning

confidence: 99%

“…At that time, synovial hyperplasia was associated to an increase of medullar cells in the epiphyseal region and formation of canals between the bone marrow and the joint cavity. 34 Histological analysis suggested that MSCs could migrate from the bone marrow. Up to 2% of the cells stained positively for one marker of MSCs, the bone morphogenetic protein receptor (BMPR)-I, and negatively for the HSC-specific CD34 marker.…”

Section: Hematopoietic and Mscs In Autoimmune Diseasesmentioning

confidence: 99%