Inflammation-responsive nanoparticles suppress lymphatic clearance for prolonged arthritis therapy

Qin, Xianyan; Pan, Li‐Hua; Chen, Tao; Li, Daming; Lin, Xin; Li, Guojiao; Feng, Chenglan; Ye, Wenchao; Liang, Wenlang; Chen, Junying; Wang, Qin

doi:10.1016/j.jconrel.2022.11.005

Cited by 12 publications

(3 citation statements)

References 40 publications

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“…In inflammatory joints, acidic pH-induced Dex dispersion or macrophage-induced specialized interaction with PSA could cause DKPNPs to reassemble from NPs to nanofibers, resulting in decreased lymph removal and extended potency. 534 At present, sinomenine hydrochloride (SIN) formulations, a natural DMARD, are utilized to treat RA; nevertheless, SIN’s potency is severely hampered by its brief half-life, poor bioavailability, and dose-relied side effects. In vivo images revealed that the superior immune-escape characteristics of the biomimetic NPs based on Prussian blue NPs led to significantly higher circulatory half-life and drug concentrations at arthritic regions of arthritis rodents.…”

Section: Nanotechnology In Non-infectious Inflammatory Diseasesmentioning

confidence: 99%

Nanotechnology’s frontier in combatting infectious and inflammatory diseases: prevention and treatment

Huang,

Guo,

et al. 2024

Sig Transduct Target Ther

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Inflammation-associated diseases encompass a range of infectious diseases and non-infectious inflammatory diseases, which continuously pose one of the most serious threats to human health, attributed to factors such as the emergence of new pathogens, increasing drug resistance, changes in living environments and lifestyles, and the aging population. Despite rapid advancements in mechanistic research and drug development for these diseases, current treatments often have limited efficacy and notable side effects, necessitating the development of more effective and targeted anti-inflammatory therapies. In recent years, the rapid development of nanotechnology has provided crucial technological support for the prevention, treatment, and detection of inflammation-associated diseases. Various types of nanoparticles (NPs) play significant roles, serving as vaccine vehicles to enhance immunogenicity and as drug carriers to improve targeting and bioavailability. NPs can also directly combat pathogens and inflammation. In addition, nanotechnology has facilitated the development of biosensors for pathogen detection and imaging techniques for inflammatory diseases. This review categorizes and characterizes different types of NPs, summarizes their applications in the prevention, treatment, and detection of infectious and inflammatory diseases. It also discusses the challenges associated with clinical translation in this field and explores the latest developments and prospects. In conclusion, nanotechnology opens up new possibilities for the comprehensive management of infectious and inflammatory diseases.

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Section: Nanotechnology In Non-infectious Inflammatory Diseasesmentioning

confidence: 99%

Nanotechnology’s frontier in combatting infectious and inflammatory diseases: prevention and treatment

Huang,

Guo,

et al. 2024

Sig Transduct Target Ther

View full text Add to dashboard Cite

show abstract

“…Upon reaching inflammatory articulation, acidic pH-triggered Dex dissociation or inflammatory macrophage-induced PSA ligand-receptor-specific binding induces the conversion of DKPNPs from NPs to nanofibers, which inhibits the clearance of the drug from the lymphatic vessels, ultimately enhancing the effectiveness of medications. 149 …”

Section: Modification Of Nanomaterialsmentioning

confidence: 99%

Functional Nanomaterials for the Treatment of Osteoarthritis

Yi,

Leng,

Wang

et al. 2024

IJN

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“…IOK hydrogel was able to function as a drug reservoir to enhance the ability of sustained drug release and reduce the number of drug administration to improve compliance. When the hydrogel was injected into the synovium of the inflamed joint in situ, the degree of protonation of IOK peptide increased under the stimulation of the slightly acidic synovium microenvironment [ 38 , 39 ] so that the electrostatic repulsion enhanced, leading to the collapse of hydrogel and accelerated released of BiNS/PEI and MTX directly in synovium. Under inflammatory conditions, folate receptor was highly expressed on surface of macrophages which was convenient for cell uptake [ 40 ].…”

Section: Introductionmentioning

confidence: 99%

Synovium microenvironment-responsive injectable hydrogel inducing modulation of macrophages and elimination of synovial fibroblasts for enhanced treatment of rheumatoid arthritis

Wu,

Ge,

Wang

et al. 2024

J Nanobiotechnol

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Rheumatoid arthritis (RA) is a progressive autoimmune disease accompanied by joint swelling, cartilage erosion and bone damage. Drug therapy for RA has been restricted due to poor therapeutic effect, recurrence and adverse effects. Macrophages and synovial fibroblasts both play important roles in the pathology of RA. Macrophages secrete large amount of pro-inflammatory cytokines, while synovial fibroblasts are tightly correlated with hypoxia synovium microenvironment, cytokine release, recruitment of pro-inflammatory cells, bone and cartilage erosion. Therefore, in this timely research, an injectable and pH-sensitive peptide hydrogel loading methotrexate (MTX) and bismuthene nanosheet/polyethyleneimine (BiNS/PEI) has been developed to reduce the activity of macrophages and eliminate over-proliferated synovial fibroblasts simultaneously. MTX can reduce the cytokine secretion of macrophages/anti-apoptosis property of synovial fibroblasts and BiNS/PEI can eliminate synovial fibroblasts via photodynamic therapy (PDT) and photothermal therapy (PTT) routes. The hydrogel was injected into the acidic inflammatory synovium for precise targeting and served as a drug reservoir for pH responsive and sustained drug release, while improving the bioavailability and reducing the toxicity of MTX. Excellent therapeutic efficacy has been achieved in both in vivo and in vitro studies, and this unique drug delivery system provides a new and robust strategy to eliminate synovial fibroblasts and modulate immune system for RA treatment in clinical. Graphic Abstract

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Inflammation-responsive nanoparticles suppress lymphatic clearance for prolonged arthritis therapy

Cited by 12 publications

References 40 publications

Nanotechnology’s frontier in combatting infectious and inflammatory diseases: prevention and treatment

Nanotechnology’s frontier in combatting infectious and inflammatory diseases: prevention and treatment

Functional Nanomaterials for the Treatment of Osteoarthritis

Synovium microenvironment-responsive injectable hydrogel inducing modulation of macrophages and elimination of synovial fibroblasts for enhanced treatment of rheumatoid arthritis

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