Inflammations mediators and circulating levels of matrix metalloproteinases: Biomarkers of diabetes in Tunisians metabolic syndrome patients

Zayani, Y.; Golli, Nargess El; Zidi, Wiem; Guizani, Imen; Boussairi, S.; Aloui, S.; Ayadi, Imen; Ftouhi, B.; Feki, Moncef; Romdhane, Neïla Ben; Sliman, Hedia Ben; Allal-Elasmi, Monia; Kaabachi, Naziha

doi:10.1016/j.cyto.2016.07.009

Cited by 13 publications

(12 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…36 Furthermore, oxidative stress regulates their expression. 34 NOV is an adipocytokine involved in obesity-associated insulin resistance. According to a recent study 37 NOV−/− mice on high fat diet had lower body weight, lower fat mass and improved glucose tolerance and insulin sensitivity.…”

Section: Discussionmentioning

confidence: 99%

“…33 In that study, resveratrol promoted the attenuation of left ventricular diastolic dysfunction by decreasing FGF basic. MMP-9 is a dysglycaemia marker 34 that fits with an early stage of cardiovascular disease as MMPs are synthetized in atherosclerotic plaques, and MMP activity is correlated with unstable angina and plaque rupture. 34 Diabetes mellitus increases vascular MMP activity.…”

Section: Discussionmentioning

confidence: 99%

“…MMP-9 is a dysglycaemia marker 34 that fits with an early stage of cardiovascular disease as MMPs are synthetized in atherosclerotic plaques, and MMP activity is correlated with unstable angina and plaque rupture. 34 Diabetes mellitus increases vascular MMP activity. 35 MMPs are stored in cytoplasmic secretory granules in endothelial cells, ready for rapid release by angiogenic stimuli.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Pituitary adenylate cyclase-activating polypeptide ameliorates vascular dysfunction induced by hyperglycaemia

Solymár

Ivić

Balaskó

et al. 2018

Diabetes and Vascular Disease Research

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Pituitary adenylate cyclase-activating polypeptide ameliorates vascular dysfunction induced by hyperglycaemia

Solymár

Ivić

Balaskó

et al. 2018

Diabetes and Vascular Disease Research

View full text Add to dashboard Cite

show abstract

“…Microalbuminuria is a remarkable biomarker for the diagnosis of DN 30 . Inflammatory biomarkers including WBC, TNF-α, matrix metalloproteinases (MMT) and dysglycemia are expressed concurrently to fit with the early stages of CVD in patients with diabetes 31 . Low high-sensitivity C-reactive protein (hs-CRP) levels in patients with DM are associated with a high risk of CAS 32 .…”

Section: Discussionmentioning

confidence: 99%

Red cell distribution width as a significant indicator of medication and prognosis in type 2 diabetic patients

Xiong

Yang

Chen

et al. 2017

Sci Rep

View full text Add to dashboard Cite

Whether red cell distribution width (RDW) can be a potential indicator for diabetic nephropathy (DN) is unknown. A total of 809 type 2 diabetes mellitus (T2D) patients were divided into 4 groups according to the quartiles (Q) of the RDW (%): Q1 ≤ 12.4 (n = 229), 12.4 < Q2 ≤ 12.9 (n = 202), 12.9 < Q3 < 13.5 (n = 168), Q4 ≥ 13.5 (n = 210). Results showed that the levels in Q4 group was higher in age, disease duration, systolic blood pressure, blood urea nitrogen, creatinine, uric acid and proteinuria but lower in hemoglobin, serum albumin and glycosylated hemoglobin compared to Q1 group. Furthermore, the incidences of DN, diabetic peripheral neuropathy, hypertension and coronary heart disease in the Q3 or Q4 group were higher compared to Q1 group. Medications including calcium channel blockers and antiplatelet therapy also showed higher frequencies in Q3 or Q4 group compared to Q1. Logistic regression indicated that the antiplatelet therapy (OR = 2.065), hypertension (OR = 2.819), creatinine (OR = 4.473) and proteinuria (OR = 2.085) were positively associated with level of Q4 group, but higher hemoglobin (OR = 0.021) and serum Ca2+ (OR = 0.178) were negatively associated with Q4. This data suggest that high level of RDW in T2D patients indicates a higher risk and a poor prognosis for DN.

show abstract

“…Matrix metalloproteinases (MMPs) belonged to extracellular matrix (ECM)-degrading enzymes participated in the mechanisms of inflammation and angiogenesis [ 9 ]. To date, preclinical researches revealed that these MMPs had great potential in cardiovascular disease therapy and diabetes biomarkers screening [ 10 – 11 ]. As for cancers, MMPs have been shown as characteristic sign of tumor invasion and prognosis [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Association between MMP2-1306 C/T polymorphism and prostate cancer susceptibility: a meta-analysis based on 3906 subjects

et al. 2017

View full text Add to dashboard Cite

Numerous investigations have addressed the correlation between MMP2-1306C/T polymorphism and prostate cancer (PCa) susceptibility. However, these conclusions were controversial. Thus, we conducted this current meta-analysis based on six studies from PubMed, Embase, Cochrane Library, China Biology Medicine disc (CBM), China National Knowledge Infrastructure (CNKI) up to October 21st, 2016. Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to evaluate the strength of the correlations. Additionally, different subgroup analyses and publication bias tests were performed. Eventually, six previous investigations consisted of 1920 cases and 1986 controls were identified and involved in this meta-analysis. Consequently, our evidence indicates a certain association between MMP2-1306C/T polymorphism and PCa risk among overall population (T vs C: OR = 1.12, 95% CI = 1.00-1.24, P = 0.040; TT+CT vs CC: OR = 1.16, 95% CI = 1.02-1.32, P = 0.026; respectively), as well as the subgroups of Asian population (T vs C: OR=1.48, 95% CI=1.13-1.94, P=0.004; TT+CT vs CC: OR = 1.66, 95% CI = 1.21-2.28, P = 0.002; respectively) and PCR-RFLP genotyped method (T vs C: OR = 1.58, 95% CI = 1.19-2.10, P = 0.001; TT+CT vs CC: OR = 1.71, 95% CI = 1.23-2.38, P = 0.001; respectively). However, no association was detected in MMP2-1306C/T polymorphism with Gleason grading or pathological stage of PCa. Our study indicates MMP2-1306 C/T polymorphism might increase PCa risk, particularly for Asian population. However, future studies comprising large cohort size from multicenter are required to confirm our conclusions.

show abstract

Inflammations mediators and circulating levels of matrix metalloproteinases: Biomarkers of diabetes in Tunisians metabolic syndrome patients

Cited by 13 publications

References 37 publications

Pituitary adenylate cyclase-activating polypeptide ameliorates vascular dysfunction induced by hyperglycaemia

Pituitary adenylate cyclase-activating polypeptide ameliorates vascular dysfunction induced by hyperglycaemia

Red cell distribution width as a significant indicator of medication and prognosis in type 2 diabetic patients

Association between MMP2-1306 C/T polymorphism and prostate cancer susceptibility: a meta-analysis based on 3906 subjects

Contact Info

Product

Resources

About