Inflammatory Biomarkers Predictive of Metabolic Syndrome in a Nigerian Population: A Case-Control Study

Abstract

Background: Inflammation is linked to the aetiopathogenesis of Metabolic syndrome (MetS).
 Objective: To assess the ability of high sensitivity C-Reactive Protein (hs-CRP), Tumour Necrosis Factor-alpha (TNFα) and Interleukin-6 (IL-6) to predict MetS.
 Methods: A case-control study involving 123 subjects with MetS (cases) and age-matched 123 subjects. without MetS (controls) was conducted. The levels of TNFα, IL-6, and hs-CRP between independent groups were compared. The Receiver Operative Characteristic Curve was used to assess the ability of inflammatory markers to discriminately identify MetS.
 Results: The mean age of the case and control groups was 49.9±0.9 years and 48.1±1.1 years (p = 0.274) respectively. The median levels of TNFα, IL-6 and hS-CRP were significantly higher among the cases than the control group in both genders (p <0.001). There was a significant increase in the serum values of the markers with increasing components of MetS (p <0.001). The Area Under the Curve of TNFα, IL-6 and hs-CRP was > 0.9 in both males and females.
 Conclusion: TNFα, IL-6, and hs-CRP identified MetS. There is a need for further studies to determine the inflammatory marker most predictive of MetS.

Association of baseline and changes in adiponectin, homocysteine, high-sensitivity C-reactive protein, interleukin-6, and interleukin-10 levels and metabolic syndrome incidence: Tehran lipid and glucose study

“…In the current study, multivariate logistic regression analyses showed that a unit increase in IL-6 levels elevated the risk of MetS by 9% in the "persistent MetS" group. Previous cross-sectional studies found a positive relationship between IL-6 levels and the prevalence of MetS in the Iranian population [ [56] , [57] , [58] ], including the TLGS community [ 59 ], and in other populations [ [60] , [61] , [62] , [63] , [64] , [65] ]. The convergence of the pathological mechanisms involved in the pathogenesis of MetS leads to a pro-inflammatory state, which explains the increased levels of several inflammatory biomarkers, including IL-6 and CRP, in individuals with MetS.…”