2009
DOI: 10.1186/1756-0500-2-221
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Inflammatory bowel disease activity assessed by fecal calprotectin and lactoferrin: correlation with laboratory parameters, clinical, endoscopic and histological indexes

Abstract: BackgroundResearch has shown that fecal biomarkers are useful to assess the activity of inflammatory bowel disease (IBD). The aim of the study is: to evaluate the efficacy of the fecal lactoferrin and calprotectin as indicators of inflammatory activity.FindingsA total of 78 patients presenting inflammatory bowel disease were evaluated. Blood tests, the Crohn's Disease Activity Index (CDAI), Mayo Disease Activity Index (MDAI), and Crohn's Disease Endoscopic Index of Severity (CDEIS) were used for the clinical a… Show more

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Cited by 108 publications
(86 citation statements)
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References 27 publications
(38 reference statements)
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“…Concentrations between 0 and 50 mg/kg of stool were treated as normal values; positive result meant that the concentration was above 50 mg/kg of feces (norm I = NI). In active inflammatory bowel disease concentration of calprotectin is usually between 200 and 20,000 mg/kg of feces, what was regarded as a norm II (NII) [2,9,17].…”
Section: Methodsmentioning
confidence: 99%
“…Concentrations between 0 and 50 mg/kg of stool were treated as normal values; positive result meant that the concentration was above 50 mg/kg of feces (norm I = NI). In active inflammatory bowel disease concentration of calprotectin is usually between 200 and 20,000 mg/kg of feces, what was regarded as a norm II (NII) [2,9,17].…”
Section: Methodsmentioning
confidence: 99%
“…8,9 FC is more sensitive than CDAI or CRP at detecting endoscopic inflammation, 9,14 and is a reliable surrogate marker of mucosal healing in patients with Crohn's disease. 8,15 Increased FC concentrations are associated with an increased risk of clinical relapse.…”
Section: A C C E P T E D Accepted Manuscriptmentioning
confidence: 99%
“…Clinical activity indices and serum inflammatory markers correlate poorly with endoscopic disease activity [9,17,18,21]. Fecal calprotectin, which is excreted by migrating neutrophils to the lumen of the inflamed bowel, has been demonstrated a useful surrogate marker for disease activity in both children and adults [18,21,22,31,32]. However, FC is not specific to inflammatory bowel disease and may increase in the presence of other gastrointestinal disorders, such as infectious colitis and polyposis [33,34].…”
Section: Discussionmentioning
confidence: 99%
“…Despite resolution of active mucosal inflammation during medical therapy for CD, FC levels may remain elevated reflecting persistent microscopic inflammation of the bowel wall [17,18,21,22,31,32]. Suggested cutoff values for detection of relapse vary between 150 and 275 μg/g, usually with moderate sensitivity but good specificity [17,18,21,32].…”
Section: Discussionmentioning
confidence: 99%
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