Inflammatory bowel disease and risk of mortality in COPD

Vutcovici, Maria; Bitton, Alain; Ernst, Pierre; Kezouh, Abbas; Suissa, Samy; Brassard, Paul

doi:10.1183/13993003.01945-2015

Cited by 41 publications

(26 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We identified 458 studies from different databases and society meetings; 9 of them were selected after screening. Five studies were excluded with reason [26–30] and four were included for the qualitative and quantitative analysis; three were published papers [18, 31, 32] and one was a meeting abstract [33]. Figure 1 describes the summary of the literature search according to PRISMA standards.…”

Section: Resultsmentioning

confidence: 99%

Association between inflammatory bowel disease and chronic obstructive pulmonary disease: a systematic review and meta-analysis

et al. 2019

View full text Add to dashboard Cite

IntroductionThere is evidence of an association between inflammatory bowel disease (IBD) and lung conditions such as chronic obstructive pulmonary disease (COPD). This systematic review and meta-analysis explored the risk of new onset IBD in patients with COPD and new onset COPD in IBD patients.MethodsWe performed a systematic review of observational studies exploring the risk of both associations. Two independent reviewers explored the EMBASE, MEDLINE, LILACS and DOAJ databases, and the risk of bias was evaluated using the ROBBINS-I tool. Data from included studies was pooled in a random effect meta-analysis following a DerSimonian-Laird method. The quality of the evidence was ranked using GRADE criteria.ResultsFour studies including a pooled population of 1355 new cases were included. We found association between new onset IBD in COPD population. The risk of bias was low in most of them. Only one study reported tobacco exposure as a potential confounding factor. The pooled risk ratio (RR) for a new diagnosis of IBD in COPD patients was 2.02 (CI, 1.56 to 2.63), I2 = 72% (GRADE: low). The subgroup analyses for Crohn’s disease and ulcerative colitis yielded RRs of 2.29 (CI, 1.51 to 3.48; I2 = 62%), and 1.79 (CI, 1.39 to 2.29; I2 = 19%.), respectively.DiscussionAccording to our findings, the risk of new onset IBD was higher in populations with COPD compared to the general population without this condition. Based on our analysis, we suggest a potential association between IBD and COPD; however, further research exploring the potential effect of confounding variables, especially cigarette smoking, is still needed.Review register(PROSPERO: CRD42018096624)

show abstract

Section: Resultsmentioning

confidence: 99%

Association between inflammatory bowel disease and chronic obstructive pulmonary disease: a systematic review and meta-analysis

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Population based studies have identified an increased prevalence of IBD in patients with COPD, and an increased risk of mortality in patients with both COPD and CD ( 13 – 15 ). Furthermore, the risk of COPD patients developing either CD or UC is increased by 2.72 and 1.83, respectively, compared to healthy controls ( 13 ), results that have been confirmed in additional populations ( 16 ).…”

Section: Chronic Inflammatory Diseasesmentioning

confidence: 99%

Links Between Inflammatory Bowel Disease and Chronic Obstructive Pulmonary Disease

et al. 2020

View full text Add to dashboard Cite

Inflammatory bowel disease (IBD) and chronic obstructive pulmonary disease (COPD) are chronic inflammatory diseases of the gastrointestinal and respiratory tracts, respectively. These mucosal tissues bear commonalities in embryology, structure and physiology. Inherent similarities in immune responses at the two sites, as well as overlapping environmental risk factors, help to explain the increase in prevalence of IBD amongst COPD patients. Over the past decade, a tremendous amount of research has been conducted to define the microbiological makeup of the intestine, known as the intestinal microbiota, and determine its contribution to health and disease. Intestinal microbial dysbiosis is now known to be associated with IBD where it impacts upon intestinal epithelial barrier integrity and leads to augmented immune responses and the perpetuation of chronic inflammation. While much less is known about the lung microbiota, like the intestine, it has its own distinct, diverse microflora, with dysbiosis being reported in respiratory disease settings such as COPD. Recent research has begun to delineate the interaction or crosstalk between the lung and the intestine and how this may influence, or be influenced by, the microbiota. It is now known that microbial products and metabolites can be transferred from the intestine to the lung via the bloodstream, providing a mechanism for communication. While recent studies indicate that intestinal microbiota can influence respiratory health, intestinal dysbiosis in COPD has not yet been described although it is anticipated since factors that lead to dysbiosis are similarly associated with COPD. This review will focus on the gut-lung axis in the context of IBD and COPD, highlighting the role of environmental and genetic factors and the impact of microbial dysbiosis on chronic inflammation in the intestinal tract and lung.

show abstract

“…Interdisciplinary Perspectives on Infectious Diseases bowel disease (IBD) also have a higher prevalence of pulmonary diseases [56][57][58]. Moreover, a recent study reported the association of fecal microbiota with bronchiolitis in infants where the authors identified four distinct fecal microbiota profiles (Escherichia, Bifidobacterium, Enterobacter/Veillonella, and Bacteroides) as dominant taxa and also the association of Bacteroides with a higher likelihood of bronchiolitis [59].…”

Section: Gut-lung Axismentioning

confidence: 99%

Gut-Lung Axis in COVID-19

Allali

Bakri

Amzazi

et al. 2021

Interdisciplinary Perspectives on Infectious Diseases

View full text Add to dashboard Cite

COVID-19 is a pandemic infection of the respiratory system caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The viral ribonucleic acid (RNA) was found in many parts of the COVID-19 patients including the stool, suggesting a potential interaction with the host’s gut microbiome. The gut microbiome also plays major roles in immunity and inflammation. It also impacts pulmonary functions through the gut-lung axis. There have been recent reports of the importance of the host microbiome in infection and pathogenicity. The understanding of the gut and lung microbiomes would open the gate to new therapeutic approaches.

show abstract

Inflammatory bowel disease and risk of mortality in COPD

Cited by 41 publications

References 43 publications

Association between inflammatory bowel disease and chronic obstructive pulmonary disease: a systematic review and meta-analysis

Association between inflammatory bowel disease and chronic obstructive pulmonary disease: a systematic review and meta-analysis

Links Between Inflammatory Bowel Disease and Chronic Obstructive Pulmonary Disease

Gut-Lung Axis in COVID-19

Contact Info

Product

Resources

About