Inflammatory bowel disease pathobiology: the role of the interferon signature

Andreou, Nicolaos-Panagiotis; Legaki, Evangelia; Gazouli, Maria

doi:10.20524/aog.2020.0457

Cited by 45 publications

(51 citation statements)

References 124 publications

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“…Downregulation of DAB2 in DCs may not be limited to PAMPs but may also be compounded by the effect of the host’s inflammatory mediators. As we discussed earlier, Dab2 it has been identified as a IFNγ-responsive gene in macrophages ( 31 ) and increased mucosal IFNγ is a hallmark of Crohn’s disease and experimental murine colitis ( 64 ). Importantly, consistent with the hypothesis that DAB2 restricts DC immunogenicity, we showed that adoptive transfer of Dab2-deficient DC exacerbated experimental colitis in mice ( 23 ).…”

Section: Dab2 Expression In Immune Cells and Its Role In Inflammatorymentioning

confidence: 97%

Emerging Roles of Disabled Homolog 2 (DAB2) in Immune Regulation

2020

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Disabled-2 (DAB2) is a clathrin and cargo binding endocytic adaptor protein recognized for its multifaceted roles in signaling pathways involved in cellular differentiation, proliferation, migration, tumor suppression, and other fundamental homeostatic cellular mechanisms. The requirement for DAB2 in the canonical TGFβ signaling in fibroblasts suggested that a similar mechanism may exist in immune cells and that DAB2 may contribute to immunological tolerance and suppression of inflammatory responses. In this review, we synthesize the current state of knowledge on the roles of DAB2 in the cells of the innate and adaptive immune system, with particular focus on antigen presenting cells (APCs; macrophages and dendritic cells) and regulatory T cells (Tregs). The emerging role of DAB2 in the immune system is that of an immunoregulatory molecule with significant roles in Treg-mediated immunosuppression, and suppression of TLR signaling in APC. DAB2 itself is downregulated by inflammatory stimuli, an event that likely contributes to the immunogenic function of APC. However, contrary findings have been described in neuroinflammatory disorders, thus suggesting a highly context-specific roles for DAB2 in immune cell regulation. There is need for better understanding of DAB2 regulation and its roles in different immune cells, their specialized sub-populations, and their responses under specific inflammatory conditions.

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Section: Dab2 Expression In Immune Cells and Its Role In Inflammatorymentioning

confidence: 97%

Emerging Roles of Disabled Homolog 2 (DAB2) in Immune Regulation

2020

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“…A highly upregulated cytokine in IBD is interferon-γ (IFNγ). The role of IFNγ in IBD has been mainly attributed to immune modulation [52]. More recently, it was demonstrated that IFNγ exerts potent activity on vasculature.…”

Section: Host Immune Response and Role Of Inflammation In Ibdmentioning

confidence: 99%

Role of Inflammation in Pathophysiology of Colonic Disease: An Update

Nasef

Mehta

2020

IJMS

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Diseases of the colon are a big health burden in both men and women worldwide ranging from acute infection to cancer. Environmental and genetic factors influence disease onset and outcome in multiple colonic pathologies. The importance of inflammation in the onset, progression and outcome of multiple colonic pathologies is gaining more traction as the evidence from recent research is considered. In this review, we provide an update on the literature to understand how genetics, diet, and the gut microbiota influence the crosstalk between immune and non-immune cells resulting in inflammation observed in multiple colonic pathologies. Specifically, we focus on four colonic diseases two of which have a more established association with inflammation (inflammatory bowel disease and colorectal cancer) while the other two have a less understood relationship with inflammation (diverticular disease and irritable bowel syndrome).

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“…The patient often presents tenesmus, blood in the stool, weight loss, diarrhea, flatulence, and abdominal pain, resulting in a substantial decrease in quality of life. Furthermore, it is related to psychological disorders [23,24].…”

Section: Inflammatory Bowel Diseasesmentioning

confidence: 99%

Cannabis and Canabidinoids on the Inflammatory Bowel Diseases: Going Beyond Misuse

Carvalho

Souza

Marqui

et al. 2020

IJMS

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Inflammatory bowel diseases (IBD) are characterized by a chronic and recurrent gastrointestinal condition, including mainly ulcerative colitis (UC) and Crohn’s disease (CD). Cannabis sativa (CS) is widely used for medicinal, recreational, and religious purposes. The most studied compound of CS is tetrahydrocannabinol (THC) and cannabidiol (CBD). Besides many relevant therapeutic roles such as anti-inflammatory and antioxidant properties, there is still much controversy about the consumption of this plant since the misuse can lead to serious health problems. Because of these reasons, the aim of this review is to investigate the effects of CS on the treatment of UC and CD. The literature search was performed in PubMed/Medline, PMC, EMBASE, and Cochrane databases. The use of CS leads to the improvement of UC and CD scores and quality of life. The medical use of CS is on the rise. Although the literature shows relevant antioxidant and anti-inflammatory effects that could improve UC and CD scores, it is still not possible to establish a treatment criterion since the studies have no standardization regarding the variety and part of the plant that is used, route of administration and doses. Therefore, we suggest caution in the use of CS in the therapeutic approach of IBD until clinical trials with standardization and a relevant number of patients are performed.

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Inflammatory bowel disease pathobiology: the role of the interferon signature

Cited by 45 publications

References 124 publications

Emerging Roles of Disabled Homolog 2 (DAB2) in Immune Regulation

Emerging Roles of Disabled Homolog 2 (DAB2) in Immune Regulation

Role of Inflammation in Pathophysiology of Colonic Disease: An Update

Cannabis and Canabidinoids on the Inflammatory Bowel Diseases: Going Beyond Misuse

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